Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies

Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target

(2021) Ehsan Nourbakhsh et al.   INFLAMMOPHARMACOLOGY

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas

(2020) Katrin Aslan et al.   Nature Communications

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

(2020) Defne Bayik et al.   Cancer Discovery

The Emerging Role of Myeloid-Derived Suppressor Cells in the Glioma Immune Suppressive Microenvironment

(2020) Yajing Mi et al.   Frontiers in Immunology

Targeting Myeloid-Derived Suppressor Cell, a Promising Strategy to Overcome Resistance to Immune Checkpoint Inhibitors

(2020) Aohan Hou et al.   Frontiers in Immunology

Single-Cell Atlas Reveals Complexity of the Immunosuppressive Microenvironment of Initial and Recurrent Glioblastoma

(2020) Weilun Fu et al.   Frontiers in Immunology

Targeting glutamine metabolism enhances tumor-specific immunity by modulating suppressive myeloid cells

(2020) Min-Hee Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Glioblastoma Myeloid-Derived Suppressor Cell Subsets Express Differential Macrophage Migration Inhibitory Factor Receptor Profiles That Can Be Targeted to Reduce Immune Suppression

(2020) Tyler J. Alban et al.   Frontiers in Immunology

Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta‐analysis

(2020) Alireza Hejrati et al.   IUBMB LIFE

Myeloid Cells in Glioblastoma Microenvironment

(2020) Alessandra De Leo et al.   Cells

Glioblastoma Stem-Like Cells, Metabolic Strategy to Kill a Challenging Target

(2019) Delphine Garnier et al.   Frontiers in Oncology

Asymmetric and symmetric dimethylarginine concentration as an indicator of cardiovascular diseases in rheumatoid arthritis patients: a systematic review and meta-analysis of case-control studies

(2019) Parisa Zafari et al.   CLINICAL RHEUMATOLOGY

The impaired gene expression of adenosine monophosphate-activated kinase (AMPK), a key metabolic enzyme in leukocytes of newly diagnosed rheumatoid arthritis patients

(2019) Zahra Samimi et al.   MOLECULAR BIOLOGY REPORTS

Myeloid-derived suppressive cells promote B cell-mediated immunosuppression via transfer of PD-L1 in glioblastoma

(2019) Catalina Lee-Chang et al.   Cancer Immunology Research

Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer

(2019) Wen-Chao Wu et al.   Cancer Immunology Research

IL‐35, a double‐edged sword in cancer

(2019) Zahra Yazdani et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The role of myeloid-derived suppressor cells in the pathogenesis of rheumatoid arthritis; anti- or pro-inflammatory cells?

(2019) Misagh Rajabinejad et al.   Artificial Cells Nanomedicine and Biotechnology

Regulatory T cells for amyotrophic lateral sclerosis/motor neuron disease: A clinical and preclinical systematic review

(2019) Misagh Rajabinejad et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Carboplatin chemoresistance is associated with CD11b+/Ly6C+ myeloid release and upregulation of TIGIT and LAG3/CD160 exhausted T cells

(2019) Doxakis Anestakis et al.   MOLECULAR IMMUNOLOGY

CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas

(2019) Joseph A. Flores-Toro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid-Derived Suppressor Cells: Immune-Suppressive Cells That Impair Antitumor Immunity and Are Sculpted by Their Environment

(2018) Suzanne Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Myeloid-derived suppressor cells coming of age

(2018) Filippo Veglia et al.   NATURE IMMUNOLOGY

WHO 2016 Classification of gliomas

(2018) P. Wesseling et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Analysis of the Expression and Regulation of PD-1 Protein on the Surface of Myeloid-Derived Suppressor Cells (MDSCs)

(2018) Sorim Nam et al.   Biomolecules & Therapeutics

Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression

(2018) Christopher Groth et al.   BRITISH JOURNAL OF CANCER

The role of myeloid-derived suppressor cells in chronic infectious diseases and the current methodology available for their study

(2018) Hernán F. Peñaloza et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sulforaphane suppresses the growth of glioblastoma cells, glioblastoma stem cell–like spheroids, and tumor xenografts through multiple cell signaling pathways

(2017) Khadijeh Bijangi-Vishehsaraei et al.   JOURNAL OF NEUROSURGERY

Immunosuppressive Myeloid Cells’ Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy

(2017) Neha Kamran et al.   MOLECULAR THERAPY

In situ click chemistry generation of cyclooxygenase-2 inhibitors

(2017) Atul Bhardwaj et al.   Nature Communications

Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

(2017) Paul E. Clavijo et al.   Oncotarget

Modulating glioma-mediated myeloid-derived suppressor cell development with sulforaphane

(2017) Ravi Kumar et al.   PLoS One

Toward harmonized phenotyping of human myeloid-derived suppressor cells by flow cytometry: results from an interim study

(2016) Susanna Mandruzzato et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells

(2016) Alan L. Chang et al.   CANCER RESEARCH

Hypoxia induces myeloid-derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C-C motif) ligand 26

(2016) David Kung-Chun Chiu et al.   HEPATOLOGY

Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways

(2016) U.D. Kahlert et al.   INTERNATIONAL JOURNAL OF CANCER

The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

(2016) D. F. Quail et al.   SCIENCE

Cancer Stem Cell-Secreted Macrophage Migration Inhibitory Factor Stimulates Myeloid Derived Suppressor Cell Function and Facilitates Glioblastoma Immune Evasion

(2016) Balint Otvos et al.   STEM CELLS

The Evolving Molecular Genetics of Low-grade Glioma

(2015) Sriram Venneti et al.   ADVANCES IN ANATOMIC PATHOLOGY

Mouse models of glioma

(2015) Stanley S. Stylli et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Transcriptional regulation of myeloid-derived suppressor cells

(2015) Thomas Condamine et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increase in Both CD14-Positive and CD15-Positive Myeloid-Derived Suppressor Cell Subpopulations in the Blood of Patients With Glioma But Predominance of CD15-Positive Myeloid-Derived Suppressor Cells in Glioma Tissue

(2015) Paul R. Gielen et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function

(2015) Eva Sahakian et al.   MOLECULAR IMMUNOLOGY

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

(2015) Nicholas Butowski et al.   NEURO-ONCOLOGY

COX-2 overexpression increases malignant potential of human glioma cells through Id1

(2015) Kaiming Xu et al.   Oncotarget

Elevated endoplasmic reticulum stress reinforced immunosuppression in the tumor microenvironment via myeloid-derived suppressor cells

(2015) Bo-Ra Lee et al.   Oncotarget

B Cells Are Critical to T-cell—Mediated Antitumor Immunity Induced by a Combined Immune-Stimulatory/Conditionally Cytotoxic Therapy for Glioblastoma

(2015) Marianela Candolfi et al.   NEOPLASIA

Myeloid-derived suppressor cell heterogeneity in human cancers

(2014) Samantha Solito et al.   Annals of the New York Academy of Sciences

PDE5 inhibitors enhance the lethality of standard of care chemotherapy in pediatric CNS tumor cells

(2014) Jane L Roberts et al.   CANCER BIOLOGY & THERAPY

Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy

(2014) Michelle N. Messmer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tadalafil Reduces Myeloid-Derived Suppressor Cells and Regulatory T Cells and Promotes Tumor Immunity in Patients with Head and Neck Squamous Cell Carcinoma

(2014) D. T. Weed et al.   CLINICAL CANCER RESEARCH

The Stress-Response Sensor Chop Regulates the Function and Accumulation of Myeloid-Derived Suppressor Cells in Tumors

(2014) Paul T. Thevenot et al.   IMMUNITY

XB130 promotes proliferation and invasion of gastric cancer cells

(2014) Min Shi et al.   Journal of Translational Medicine

Sustained Radiosensitization of Hypoxic Glioma Cells after Oxygen Pretreatment in an Animal Model of Glioblastoma and In Vitro Models of Tumor Hypoxia

(2014) Ryon H. Clarke et al.   PLoS One

CD200 in CNS tumor-induced immunosuppression: the role for CD200 pathway blockade in targeted immunotherapy

(2014) Christopher L Moertel et al.   Journal for ImmunoTherapy of Cancer

Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer

(2013) P. Cheng et al.   CANCER RESEARCH

Myeloid Derived Suppressor Cells and Their Role in Diseases

(2013) Y. Kong et al.   CURRENT MEDICINAL CHEMISTRY

Tumor Necrosis Factor-α Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation

(2013) Moshe Sade-Feldman et al.   IMMUNITY

Reciprocal Relationship between Myeloid-Derived Suppressor Cells and T Cells

(2013) S. Nagaraj et al.   JOURNAL OF IMMUNOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Neutrophils and granulocytic myeloid-derived suppressor cells: immunophenotyping, cell biology and clinical relevance in human oncology

(2012) Claudia A. Dumitru et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Myeloid-derived Suppressor Cells (MDSCs) in Gliomas and Glioma-Development

(2012) Gary Kohanbash et al.   IMMUNOLOGICAL INVESTIGATIONS

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

(2012) Dennis Lindau et al.   IMMUNOLOGY

Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells

(2011) N. Obermajer et al.   BLOOD

Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13

(2011) Rachel F. Gabitass et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

COX-2 Blockade Suppresses Gliomagenesis by Inhibiting Myeloid-Derived Suppressor Cells

(2011) M. Fujita et al.   CANCER RESEARCH

Tumor-infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice

(2011) Tangying Lu et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

(2011) Je-In Youn et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Myeloid-derived suppressor cell accumulation and function in patients with newly diagnosed glioblastoma

(2011) B. Raychaudhuri et al.   NEURO-ONCOLOGY

Molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies

(2011) K. Masui et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells

(2010) Yuelong Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13

(2010) S. L. Highfill et al.   BLOOD

Experimental immunotherapy for malignant glioma: lessons from two decades of research in the GL261 model

(2010) Wim Maes et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Depletion of Regulatory T Cells Facilitates Growth of Established Tumors: A Mechanism Involving the Regulation of Myeloid-Derived Suppressor Cells by Lipoxin A4

(2010) B. Zhang et al.   JOURNAL OF IMMUNOLOGY

IL-17 Promotes Tumor Development through the Induction of Tumor Promoting Microenvironments at Tumor Sites and Myeloid-Derived Suppressor Cells

(2010) Donggou He et al.   JOURNAL OF IMMUNOLOGY

Systemic delivery of neutralizing antibody targeting CCL2 for glioma therapy

(2010) Xinmei Zhu et al.   JOURNAL OF NEURO-ONCOLOGY

Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function

(2010) Thomas Condamine et al.   TRENDS IN IMMUNOLOGY

Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation

(2009) Alberto Mantovani et al.   HUMAN IMMUNOLOGY

Mechanism Regulating Reactive Oxygen Species in Tumor-Induced Myeloid-Derived Suppressor Cells

(2009) C. A. Corzo et al.   JOURNAL OF IMMUNOLOGY

Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity

(2008) K. Movahedi et al.   BLOOD

Overexpression of Interleukin-1β Induces Gastric Inflammation and Cancer and Mobilizes Myeloid-Derived Suppressor Cells in Mice

(2008) Shuiping Tu et al.   CANCER CELL