Molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies

Clinical Significance of Molecular Biomarkers in Glioblastoma

(2014) C. Ang et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Persistent roles of signal transduction of platelet-derived growth factor B in genesis, growth, and anaplastic transformation of gliomas in an in-vivo serial transplantation model

(2011) Rina Torisu et al.   Brain Tumor Pathology

AKT Inhibition Relieves Feedback Suppression of Receptor Tyrosine Kinase Expression and Activity

(2011) Sarat Chandarlapaty et al.   CANCER CELL

Deconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors

(2011) Arkaitz Carracedo et al.   CELL CYCLE

Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin

(2011) Albert Lai et al.   JOURNAL OF CLINICAL ONCOLOGY

The effect of WHO reclassification of necrotic anaplastic oligoastrocytomas on incidence and survival in glioblastoma

(2011) Gianluca Marucci   JOURNAL OF NEURO-ONCOLOGY

Notch1 is an independent prognostic factor for patients with glioma

(2011) Jiang Li et al.   JOURNAL OF SURGICAL ONCOLOGY

MGMT promoter methylation is predictive of response to radiotherapy and prognostic in the absence of adjuvant alkylating chemotherapy for glioblastoma

(2011) A. L. Rivera et al.   NEURO-ONCOLOGY

The presence of stem cell marker-expressing cells is not prognostically significant in glioblastomas

(2011) Kyung-Jung Kim et al.   NEUROPATHOLOGY

Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome

(2011) Z. J. Reitman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma

(2011) C. Bettegowda et al.   SCIENCE

Oncogenic EGFR Signaling Activates an mTORC2-NF- B Pathway That Promotes Chemotherapy Resistance

(2011) K. Tanaka et al.   Cancer Discovery

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR-Dependent Pathway

(2011) D. Guo et al.   Cancer Discovery

Rapid and sensitive assessment of the IDH1 and IDH2 mutation status in cerebral gliomas based on DNA pyrosequencing

(2010) Jörg Felsberg et al.   ACTA NEUROPATHOLOGICA

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

(2010) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

The Next Generation of Glioma Biomarkers: MGMT Methylation, BRAF Fusions and IDH1 Mutations

(2010) Andreas Von Deimling et al.   BRAIN PATHOLOGY

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas

(2010) Deliang Guo et al.   CELL CYCLE

Wnt/beta-Catenin pathway in human glioma: expression pattern and clinical/prognostic correlations

(2010) Ce Liu et al.   CLINICAL AND EXPERIMENTAL MEDICINE

MiRNA-196 Is Upregulated in Glioblastoma But Not in Anaplastic Astrocytoma and Has Prognostic Significance

(2010) Y. Guan et al.   CLINICAL CANCER RESEARCH

IDH1 and IDH2 Mutations Are Prognostic but not Predictive for Outcome in Anaplastic Oligodendroglial Tumors: A Report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

(2010) M. J. van den Bent et al.   CLINICAL CANCER RESEARCH

The use of hsa-miR-21, hsa-miR-181b and hsa-miR-106a as prognostic indicators of astrocytoma

(2010) Feng Zhi et al.   EUROPEAN JOURNAL OF CANCER

Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?

(2010) Michael Weller et al.   Future Oncology

A clinicopathological and molecular analysis of glioblastoma multiforme with long-term survival

(2010) Prasenjit Das et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Detection of IDH1 and IDH2 Mutations by Fluorescence Melting Curve Analysis as a Diagnostic Tool for Brain Biopsies

(2010) Craig Horbinski et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Correlation between O6-methylguanine-DNA methyltransferase and survival in elderly patients with glioblastoma treated with radiotherapy plus concomitant and adjuvant temozolomide

(2010) Giuseppe Minniti et al.   JOURNAL OF NEURO-ONCOLOGY

Higher pAkt Expression Predicts a Significant Worse Prognosis in Glioblastomas

(2010) Yoshiyuki SUZUKI et al.   JOURNAL OF RADIATION RESEARCH

Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism

(2010) Z. J. Reitman et al.   JNCI-Journal of the National Cancer Institute

Molecular pathology in adult gliomas: diagnostic, prognostic, and predictive markers

(2010) Michael Jansen et al.   LANCET NEUROLOGY

mTOR signaling in glioblastoma: lessons learned from bench to bedside

(2010) D. Akhavan et al.   NEURO-ONCOLOGY

MGMT promoter methylation in malignant gliomas

(2010) Markus J. Riemenschneider et al.   Targeted Oncology

p53 and stem cells: new developments and new concerns

(2010) Tongbiao Zhao et al.   TRENDS IN CELL BIOLOGY

Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas

(2009) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

IDH1 Mutations Are Early Events in the Development of Astrocytomas and Oligodendrogliomas

(2009) Takuya Watanabe et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells

(2009) Hongping Xia et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation

(2009) Yukinari Kato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Robust Detection of EGFR Copy Number Changes and EGFR Variant III: Technical Aspects and Relevance for Glioma Diagnostics

(2009) Judith Jeuken et al.   BRAIN PATHOLOGY

PCR- and Restriction Endonuclease-Based Detection ofIDH1Mutations

(2009) Jochen Meyer et al.   BRAIN PATHOLOGY

Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain Tumors

(2009) David Capper et al.   BRAIN PATHOLOGY

Analysis ofIDH1andIDH2mutations in Japanese glioma patients

(2009) Yukihiko Sonoda et al.   CANCER SCIENCE

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Polysomy for Chromosomes 1 and 19 Predicts Earlier Recurrence in Anaplastic Oligodendrogliomas with Concurrent 1p/19q Loss

(2009) M. Snuderl et al.   CLINICAL CANCER RESEARCH

MGMTPromoter Methylation Is Prognostic but Not Predictive for Outcome to Adjuvant PCV Chemotherapy in Anaplastic Oligodendroglial Tumors: A Report From EORTC Brain Tumor Group Study 26951

(2009) Martin J. van den Bent et al.   JOURNAL OF CLINICAL ONCOLOGY

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

(2009) Michael Weller et al.   JOURNAL OF CLINICAL ONCOLOGY

NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide

(2009) Wolfgang Wick et al.   JOURNAL OF CLINICAL ONCOLOGY

Cerebral glioblastoma with oligodendrogliomal component: analysis of 36 cases

(2009) Maurizio Salvati et al.   JOURNAL OF NEURO-ONCOLOGY

Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma

(2009) David A. Reardon et al.   JOURNAL OF NEURO-ONCOLOGY

Emerging functions of microRNAs in glioblastoma

(2009) Sean Lawler et al.   JOURNAL OF NEURO-ONCOLOGY

Prognostic value of O6-methylguanine-DNA methyltransferase status in glioblastoma patients, assessed by five different methods

(2009) Lucie Karayan-Tapon et al.   JOURNAL OF NEURO-ONCOLOGY

Diagnostic Use ofIDH1/2Mutation Analysis in Routine Clinical Testing of Formalin-Fixed, Paraffin-Embedded Glioma Tissues

(2009) Craig Horbinski et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

BMI1 Sustains Human Glioblastoma Multiforme Stem Cell Renewal

(2009) M. Abdouh et al.   JOURNAL OF NEUROSCIENCE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

(2009) Michael Weller et al.   Nature Reviews Neurology

IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas

(2009) Koichi Ichimura et al.   NEURO-ONCOLOGY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations

(2009) Cameron Brennan et al.   PLoS One

The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis

(2009) D. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glioma-Derived Mutations in IDH1 Dominantly Inhibit IDH1 Catalytic Activity and Induce HIF-1 

(2009) S. Zhao et al.   SCIENCE

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma

(2009) Q.-W. Fan et al.   Science Signaling

A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma

(2009) Renee D. Read et al.   PLoS Genetics

Chromosome 1p and 19q Deletions in Glioblastoma Multiforme

(2009) David Kaneshiro et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Analysis of the IDH1 codon 132 mutation in brain tumors

(2008) Jörg Balss et al.   ACTA NEUROPATHOLOGICA

MIR-451 and Imatinib mesylate inhibit tumor growth of Glioblastoma stem cells

(2008) Hilah Gal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

(2008) Joachim Silber et al.   BMC Medicine

Gliomas With 1p/19q Codeletion:a.k.a. Oligodendroglioma

(2008) Gregory Cairncross et al.   CANCER JOURNAL

S6K1 Plays a Key Role in Glial Transformation

(2008) J. L. Nakamura et al.   CANCER RESEARCH

Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal

(2008) J. Godlewski et al.   CANCER RESEARCH

MicroRNAs 221 and 222 Bypass Quiescence and Compromise Cell Survival

(2008) R. Medina et al.   CANCER RESEARCH

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

(2008) Pawan Gulati et al.   Cell Metabolism

Development of a Real-time RT-PCR Assay for Detecting EGFRvIII in Glioblastoma Samples

(2008) K. Yoshimoto et al.   CLINICAL CANCER RESEARCH

Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme

(2008) R. Pallini et al.   CLINICAL CANCER RESEARCH

Stem Cell Marker CD133 Affects Clinical Outcome in Glioma Patients

(2008) F. Zeppernick et al.   CLINICAL CANCER RESEARCH

MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma

(2008) J. Sadones et al.   EUROPEAN JOURNAL OF CANCER

Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients

(2008) Mingyu Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Validation of Real-Time Methylation-Specific PCR to Determine O6-Methylguanine-DNA Methyltransferase Gene Promoter Methylation in Glioma

(2008) Ilse Vlassenbroeck et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

MicroRNA-128 inhibits glioma cells proliferation by targeting transcription factor E2F3a

(2008) Yu Zhang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM)

(2008) Teri N. Kreisl et al.   JOURNAL OF NEURO-ONCOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

MicroRNAs accurately identify cancer tissue origin

(2008) Nitzan Rosenfeld et al.   NATURE BIOTECHNOLOGY

Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours

(2008) V. Häyry et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The prognostic value of nestin expression in newly diagnosed glioblastoma: Report from the Radiation Therapy Oncology Group

(2008) Prakash Chinnaiyan et al.   Radiation Oncology

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

Glioblastomas: correlation between oligodendroglial components, genetic abnormalities, and prognosis

(2008) Luciana Wernersbach Pinto et al.   VIRCHOWS ARCHIV

Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-Deficient Glioblastoma

(2008) Tim F Cloughesy et al.   PLOS MEDICINE

Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3

(2007) Thierry Gorlia et al.   LANCET ONCOLOGY