Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19

Escape from X Chromosome Inactivation and the Female Predominance in Autoimmune Diseases

(2021) Ali Youness et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An overview of Betacoronaviruses-associated severe respiratory syndromes, focusing on sex-type-specific immune responses

(2021) Golbarg Rahimi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Role of Toll‐like receptors in the pathogenesis of COVID‐19

(2021) Shaghayegh Khanmohammadi et al.   JOURNAL OF MEDICAL VIROLOGY

SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to control replication in lung epithelial cells

(2021) Antoine Rebendenne et al.   JOURNAL OF VIROLOGY

Sex-disaggregated data in COVID-19 vaccine trials

(2021) Lavanya Vijayasingham et al.   LANCET

Attributes and predictors of long COVID

(2021) Carole H. Sudre et al.   NATURE MEDICINE

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

(2021) Chiara Fallerini et al.   eLife

SARS-CoV-2, SARS-CoV-1, and HIV-1 derived ssRNA sequences activate the NLRP3 inflammasome in human macrophages through a non-classical pathway

(2021) Grant R. Campbell et al.   iScience

B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells

(2021) Bingfei Yu et al.   CELL

A retrospective cohort study of 12,306 pediatric COVID-19 patients in the United States

(2021) Vibhu Parcha et al.   Scientific Reports

Excess deaths associated with covid-19 pandemic in 2020: age and sex disaggregated time series analysis in 29 high income countries

(2021) Nazrul Islam et al.   BMJ-British Medical Journal

A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection

(2021) Fiachra Humphries et al.   Science Immunology

SARS‐CoV‐2 sensing by RIG‐I and MDA5 links epithelial infection to macrophage inflammation

(2021) Lucy G Thorne et al.   EMBO JOURNAL

The early interferon catches the SARS-CoV-2

(2021) Thomas Decker   JOURNAL OF EXPERIMENTAL MEDICINE

Early nasal type I IFN immunity against SARS-CoV-2 is compromised in patients with autoantibodies against type I IFNs

(2021) Jonathan Lopez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study

(2021) Katherine A Twohig et al.   LANCET INFECTIOUS DISEASES

Pre-activated antiviral innate immunity in the upper airways controls early SARS-CoV-2 infection in children

(2021) J. Loske et al.   NATURE BIOTECHNOLOGY

Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines

(2021) Mark G. Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Children’s role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility

(2021) Katy A. M. Gaythorpe et al.   Scientific Reports

Sex Differences in Immunity to Viral Infections

(2021) Henning Jacobsen et al.   Frontiers in Immunology

How Children Are Protected From COVID-19? A Historical, Clinical, and Pathophysiological Approach to Address COVID-19 Susceptibility

(2021) Magdalena Anna Massalska et al.   Frontiers in Immunology

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

(2021) Xavier Solanich et al.   Frontiers in Immunology

RIG-I-Like Receptor-Mediated Recognition of Viral Genomic RNA of Severe Acute Respiratory Syndrome Coronavirus-2 and Viral Escape From the Host Innate Immune Responses

(2021) Takahisa Kouwaki et al.   Frontiers in Immunology

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

(2021) Takaki Asano et al.   Science Immunology

Sexual-dimorphism in human immune system aging

(2020) Eladio J. Márquez et al.   Nature Communications

Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults

(2020) Jonas F. Ludvigsson   ACTA PAEDIATRICA

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

(2020) Yvan Jamilloux et al.   AUTOIMMUNITY REVIEWS

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19

(2020) Annsea Park et al.   Cell Host & Microbe

Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China

(2020) Chuan Qin et al.   CLINICAL INFECTIOUS DISEASES

Rheumatologists’ perspective on coronavirus disease 19 (COVID-19) and potential therapeutic targets

(2020) Durga Prasanna Misra et al.   CLINICAL RHEUMATOLOGY

Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes

(2020) Cindy Patinote et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Type I IFN immunoprofiling in COVID-19 patients

(2020) Sophie Trouillet-Assant et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

COVID-19 epidemic: Disease characteristics in children

(2020) Jiatong She et al.   JOURNAL OF MEDICAL VIROLOGY

Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomes

(2020) Mario Adán Moreno-Eutimio et al.   MICROBES AND INFECTION

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7–9

(2020) Leonhard X. Heinz et al.   NATURE

COVID-19 infection in children

(2020) Ian P Sinha et al.   Lancet Respiratory Medicine

Antiviral activities of type I interferons to SARS-CoV-2 infection

(2020) Emily Mantlo et al.   ANTIVIRAL RESEARCH

Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients

(2020) Nan Wang et al.   Cell Host & Microbe

Presence of Genetic Variants Among Young Men With Severe COVID-19

(2020) Caspar I. van der Made et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical trials for COVID-19 should include sex as a variable

(2020) Evelyne Bischof et al.   JOURNAL OF CLINICAL INVESTIGATION

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

(2020) Qing Ye et al.   JOURNAL OF INFECTION

Targeting human TLRs to combat COVID‐19: A solution?

(2020) Ritwik Patra et al.   JOURNAL OF MEDICAL VIROLOGY

Immune-mediated approaches against COVID-19

(2020) Helena F. Florindo et al.   Nature Nanotechnology

Dexamethasone in Hospitalized Patients with Covid-19 — Preliminary Report

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Activation of TLR7 and Innate Immunity as an Efficient Method Against COVID-19 Pandemic: Imiquimod as a Potential Therapy

(2020) Konstantinos Poulas et al.   Frontiers in Immunology

TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women

(2020) Pascal Azar et al.   JCI Insight

Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19

(2020) Athina Angelopoulou et al.   ENVIRONMENTAL RESEARCH

Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.

(2020) Kumari G. Lokugamage et al.   JOURNAL OF VIROLOGY

Sex differences in immune responses that underlie COVID-19 disease outcomes

(2020) Takehiro Takahashi et al.   NATURE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Letter to the Editor: Toll-Like Receptor Antagonists as a Potential Therapeutic Strategy Against Cytokine Storm in COVID-19-Infected Patients

(2020) Sadegh Safaei et al.   VIRAL IMMUNOLOGY

Susceptibility to SARS-CoV-2 Infection Among Children and Adolescents Compared With Adults

(2020) Russell M. Viner et al.   JAMA Pediatrics

The Role of Type I Interferons in the Pathogenesis and Treatment of COVID-19

(2020) Gideon Schreiber   Frontiers in Immunology

Understanding Gender-Bias in Critically Ill Patients With COVID-19

(2020) Mustapha Chamekh et al.   Frontiers in Medicine

Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones

(2020) Anissa Viveiros et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sex and age differences in COVID-19 mortality in Europe

(2020) Linda Juel Ahrenfeldt et al.   WIENER KLINISCHE WOCHENSCHRIFT

Male sex identified by global COVID-19 meta-analysis as a risk factor for death and ITU admission

(2020) Hannah Peckham et al.   Nature Communications

Heterogeneous Escape from X Chromosome Inactivation Results in Sex Differences in Type I IFN Responses at the Single Human pDC Level

(2020) Sven Hendrik Hagen et al.   Cell Reports

Severe Acute Respiratory Syndrome Coronavirus-2 Induces Cytokine Storm and Inflammation During Coronavirus Disease 19: Perspectives and Possible Therapeutic Approaches

(2020) Federica Mannino et al.   Frontiers in Pharmacology

Sex and Pubertal Differences in the Type 1 Interferon Pathway Associate With Both X Chromosome Number and Serum Sex Hormone Concentration

(2019) Kate Webb et al.   Frontiers in Immunology

Factors affecting sex-related reporting in medical research: a cross-disciplinary bibliometric analysis

(2019) Cassidy R Sugimoto et al.   LANCET

Copy number of the X ‐ linked genes TLR 7 and CD 40L influences innate and adaptive immune responses

(2019) Luis Sarmiento et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

(2019) Rudragouda Channappanavar et al.   JOURNAL OF CLINICAL INVESTIGATION

Skewed X-inactivation is common in the general female population

(2018) Ekaterina Shvetsova et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation

(2018) Mélanie Souyris et al.   Seminars in Immunopathology

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

(2017) Rudragouda Channappanavar et al.   JOURNAL OF IMMUNOLOGY

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

(2017) Rudragouda Channappanavar et al.   Seminars in Immunopathology

Inherent X-Linked Genetic Variability and Cellular Mosaicism Unique to Females Contribute to Sex-Related Differences in the Innate Immune Response

(2017) Zoltan Spolarics et al.   Frontiers in Immunology

Differential Susceptibility to Infectious Respiratory Diseases between Males and Females Linked to Sex-Specific Innate Immune Inflammatory Response

(2017) Mustapha Chamekh et al.   Frontiers in Immunology

Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice

(2016) Rudragouda Channappanavar et al.   Cell Host & Microbe

Escape Artists of the X Chromosome

(2016) Bradley P. Balaton et al.   TRENDS IN GENETICS

Sex differences in immune responses to infectious diseases

(2015) Julia Fischer et al.   INFECTION

Guanosine and its modified derivatives are endogenous ligands for TLR7

(2015) Takuma Shibata et al.   INTERNATIONAL IMMUNOLOGY

X-chromosome inactivation and escape

(2015) CHRISTINE M. DISTECHE et al.   JOURNAL OF GENETICS

Female Bias in Systemic Lupus Erythematosus is Associated with the Differential Expression of X-Linked Toll-Like Receptor 8

(2015) Gabrielle McDonald et al.   Frontiers in Immunology

Variable escape from X-chromosome inactivation: Identifying factors that tip the scales towards expression

(2014) Samantha B. Peeters et al.   BIOESSAYS

Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus

(2014) Benjamin R. Umiker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

X-Chromosome Genetic Association Test Accounting for X-Inactivation, Skewed X-Inactivation, and Escape from X-Inactivation

(2014) Jian Wang et al.   GENETIC EPIDEMIOLOGY

TLR7 Is Involved in Sequence-Specific Sensing of Single-Stranded RNAs in Human Macrophages

(2014) M. P. Gantier et al.   JOURNAL OF IMMUNOLOGY

X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women

(2014) Sophie Laffont et al.   JOURNAL OF IMMUNOLOGY

Sex Differences in Pediatric Infectious Diseases

(2014) M. Muenchhoff et al.   JOURNAL OF INFECTIOUS DISEASES

Natural History and Management of Hepatitis C: Does Sex Play a Role?

(2014) R. Baden et al.   JOURNAL OF INFECTIOUS DISEASES

RNA recognition by human TLR8 can lead to autoimmune inflammation

(2013) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SeXX matters in immunity

(2013) J.G. Markle et al.   TRENDS IN IMMUNOLOGY

TLR8: the forgotten relative revindicated

(2012) Jorge L Cervantes et al.   Cellular & Molecular Immunology

TLR7 and TLR9 in SLE: when sensing self goes wrong

(2012) T. Celhar et al.   IMMUNOLOGIC RESEARCH

Child Mortality Estimation: Estimating Sex Differences in Childhood Mortality since the 1970s

(2012) Cheryl Chriss Sawyer   PLOS MEDICINE

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor   signaling

(2011) C. Seillet et al.   BLOOD

Genes that escape from X inactivation

(2011) Joel B. Berletch et al.   HUMAN GENETICS

The X chromosome and immune associated genes

(2011) Ilaria Bianchi et al.   JOURNAL OF AUTOIMMUNITY

Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population

(2010) H. Garcia-Ortiz et al.   ANNALS OF THE RHEUMATIC DISEASES

Genetic modulation of TLR8 response following bacterial phagocytosis

(2010) Michael P. Gantier et al.   HUMAN MUTATION

Aging is associated with a numerical and functional decline in plasmacytoid dendritic cells, whereas myeloid dendritic cells are relatively unaltered in human peripheral blood

(2009) Yu Jing et al.   HUMAN IMMUNOLOGY

Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

(2009) Angela Meier et al.   NATURE MEDICINE

Signalling pathways leading to IFN-α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications

(2008) C. Guiducci et al.   JOURNAL OF INTERNAL MEDICINE