Differential Susceptibility to Infectious Respiratory Diseases between Males and Females Linked to Sex-Specific Innate Immune Inflammatory Response

Expression of X-linked Toll-like receptor 4 signaling genes in female vs. male neonates

(2017) David N. O’Driscoll et al.   PEDIATRIC RESEARCH

Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms

(2015) Muneeb Salie et al.   INFECTION GENETICS AND EVOLUTION

Sex-based differences in immune function and responses to vaccination

(2015) S. L. Klein et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women

(2014) Sophie Laffont et al.   JOURNAL OF IMMUNOLOGY

Biological Differences Between the Sexes and Susceptibility to Tuberculosis

(2014) S. Nhamoyebonde et al.   JOURNAL OF INFECTIOUS DISEASES

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment

(2013) Anca Dorhoi et al.   JOURNAL OF CLINICAL INVESTIGATION

miR-223: infection, inflammation and cancer

(2013) M. Haneklaus et al.   JOURNAL OF INTERNAL MEDICINE

Cellular mosaicism for X-linked polymorphisms and IRAK1 expression presents a distinct phenotype and improves survival following sepsis

(2013) Rachna Chandra et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Sex and inflammation in respiratory diseases: a clinical viewpoint

(2013) Georges J Casimir et al.   Biology of Sex Differences

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression

(2012) G. Zardo et al.   BLOOD

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

MicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis

(2012) Nan Shen et al.   Nature Reviews Rheumatology

Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9

(2012) Stephanie Traub et al.   PLoS One

Sex-specific signaling through Toll-Like Receptors 2 and 4 contributes to survival outcome of Coxsackievirus B3 infection in C57Bl/6 mice

(2012) Brian J Roberts et al.   Biology of Sex Differences

Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice

(2011) R. S. Scotland et al.   BLOOD

MicroRNAs and the resolution phase of inflammation in macrophages

(2011) Muhammad M. Alam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Sexual dimorphism in lung function responses to acute influenza A infection

(2011) Alexander N. Larcombe et al.   Influenza and Other Respiratory Viruses

Sex-Based Differences in Susceptibility to Respiratory and Systemic Pneumococcal Disease in Mice

(2011) Aras Kadioglu et al.   JOURNAL OF INFECTIOUS DISEASES

MicroRNA, a new paradigm for understanding immunoregulation, inflammation, and autoimmune diseases

(2011) Rujuan Dai et al.   Translational Research

Serum miR-146a and miR-223 as potential new biomarkers for sepsis

(2010) Jia-feng Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IRAK1 functional genetic variant affects severity of septic shock*

(2010) Julie Toubiana et al.   CRITICAL CARE MEDICINE

Gender dependent importance of IRAK-1 in dextran sulfate sodium induced colitis

(2009) Martin Berglund et al.   CELLULAR IMMUNOLOGY

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

(2009) Changsheng Du et al.   NATURE IMMUNOLOGY

Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

(2009) Angela Meier et al.   NATURE MEDICINE

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

(2009) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothesis: Increased male mortality caused by infection is due to a decrease in heterozygous loci as a result of a single X chromosome

(2008) James A. Morris et al.   MEDICAL HYPOTHESES

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

Regulation of progenitor cell proliferation and granulocyte function by microRNA-223

(2008) Jonathan B. Johnnidis et al.   NATURE

MicroRNAs: new regulators of immune cell development and function

(2008) David Baltimore et al.   NATURE IMMUNOLOGY

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY

Genetic Association and Expression Studies Indicate a Role of Toll-Like Receptor 8 in Pulmonary Tuberculosis

(2008) Sonia Davila et al.   PLoS Genetics