The Role of Type I Interferons in the Pathogenesis and Treatment of COVID-19
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Role of Type I Interferons in the Pathogenesis and Treatment of COVID-19
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 11, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-09-30
DOI
10.3389/fimmu.2020.595739
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Effect of Intravenous Interferon β-1a on Death and Days Free From Mechanical Ventilation Among Patients With Moderate to Severe Acute Respiratory Distress Syndrome
- (2020) V. Marco Ranieri et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations
- (2020) Stephan Wilmes et al. SCIENCE
- Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
- (2020) Daniel Wrapp et al. SCIENCE
- Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
- (2020) Daniel Blanco-Melo et al. CELL
- SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues
- (2020) Carly G.K. Ziegler et al. CELL
- SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
- (2020) Markus Hoffmann et al. CELL
- Type I and Type III Interferons – Induction, Signaling, Evasion, and Application to Combat COVID-19
- (2020) Annsea Park et al. Cell Host & Microbe
- Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine
- (2020) Wanbo Tai et al. Cellular & Molecular Immunology
- COVID-19 Outbreak: An Overview
- (2020) Marco Ciotti et al. CHEMOTHERAPY
- Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China
- (2020) Chuan Qin et al. CLINICAL INFECTIOUS DISEASES
- COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons
- (2020) Shivraj Hariram Nile et al. CYTOKINE & GROWTH FACTOR REVIEWS
- SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells
- (2020) Soeren Lukassen et al. EMBO JOURNAL
- Pathogenesis of COVID-19 from a cell biology perspective
- (2020) Robert J. Mason EUROPEAN RESPIRATORY JOURNAL
- Type I IFN immunoprofiling in COVID-19 patients
- (2020) Sophie Trouillet-Assant et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial
- (2020) Ivan Fan-Ngai Hung et al. LANCET
- SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
- (2020) Waradon Sungnak et al. NATURE MEDICINE
- Interferon-α2b Treatment for COVID-19
- (2020) Qiong Zhou et al. Frontiers in Immunology
- Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
- (2020) Bo Diao et al. Frontiers in Immunology
- Generation of a Broadly Useful Model for COVID-19 Pathogenesis, Vaccination, and Treatment
- (2020) Jing Sun et al. CELL
- Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients
- (2020) Nan Wang et al. Cell Host & Microbe
- Dysregulation of the immune response affects the outcome of critical COVID‐19 patients
- (2020) Lin‐lin Wei et al. JOURNAL OF MEDICAL VIROLOGY
- Age-dependent effects in the transmission and control of COVID-19 epidemics
- (2020) Nicholas G. Davies et al. NATURE MEDICINE
- Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
- (2020) Jérôme Hadjadj et al. SCIENCE
- Type I and III interferons disrupt lung epithelial repair during recovery from viral infection
- (2020) Jack Major et al. SCIENCE
- Activation and evasion of type I interferon responses by SARS-CoV-2
- (2020) Xiaobo Lei et al. Nature Communications
- COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses
- (2020) Muhammad Adnan Shereen et al. Journal of Advanced Research
- The coding capacity of SARS-CoV-2
- (2020) Yaara Finkel et al. NATURE
- The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway
- (2020) Jin-Yan Li et al. VIRUS RESEARCH
- SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant
- (2020) Yoriyuki Konno et al. Cell Reports
- IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes
- (2019) Rudragouda Channappanavar et al. JOURNAL OF CLINICAL INVESTIGATION
- CRISPR/Cas9-based Knockout Strategy Elucidates Components Essential for Type 1 Interferon Signaling in Human HeLa Cells
- (2019) Victoria Urin et al. JOURNAL OF MOLECULAR BIOLOGY
- Viral dedication to vigorous destruction of interferon receptors
- (2018) Chuan Xia et al. VIROLOGY
- Ebolaviruses: New roles for old proteins
- (2018) Diego Cantoni et al. PLoS Neglected Tropical Diseases
- Regulation of type I interferon signaling in immunity and inflammation: A comprehensive review
- (2017) Kun Chen et al. JOURNAL OF AUTOIMMUNITY
- The molecular basis for differential type I interferon signaling
- (2017) Gideon Schreiber JOURNAL OF BIOLOGICAL CHEMISTRY
- Defining the distinct, intrinsic properties of the novel type I interferon, IFNϵ
- (2017) Sebastian A. Stifter et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural Insights into the Interaction of Coronavirus Papain-Like Proteases and Interferon-Stimulated Gene Product 15 from Different Species
- (2017) Courtney M. Daczkowski et al. JOURNAL OF MOLECULAR BIOLOGY
- STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling
- (2017) Kei-ichiro Arimoto et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology
- (2017) Rudragouda Channappanavar et al. Seminars in Immunopathology
- STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling
- (2017) Kei-ichiro Arimoto et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Role of Interferons in Inflammation and Inflammasome Activation
- (2017) Nataša Kopitar-Jerala Frontiers in Immunology
- Type I Interferons as Regulators of Lung Inflammation
- (2017) Spyridon Makris et al. Frontiers in Immunology
- Interferon β-1a for the treatment of Ebola virus disease: A historically controlled, single-arm proof-of-concept trial
- (2017) Mandy Kader Konde et al. PLoS One
- Dysregulated Type I Interferon and Inflammatory Monocyte-Macrophage Responses Cause Lethal Pneumonia in SARS-CoV-Infected Mice
- (2016) Rudragouda Channappanavar et al. Cell Host & Microbe
- The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses
- (2016) Katarzyna Blaszczyk et al. CYTOKINE & GROWTH FACTOR REVIEWS
- A review of treatment modalities for Middle East Respiratory Syndrome
- (2016) Yin Mo et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Therapeutic Elimination of the Type 1 Interferon Receptor for Treating Psoriatic Skin Inflammation
- (2016) Jun Gui et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Type-I Interferon Responses: From Friend to Foe in the Battle against Chronic Viral Infection
- (2016) Armstrong Murira et al. Frontiers in Immunology
- STAT2/IRF9 directs a prolonged ISGF3-like transcriptional response and antiviral activity in the absence of STAT1
- (2015) Katarzyna Blaszczyk et al. BIOCHEMICAL JOURNAL
- Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins
- (2015) Edmond M. Linossi et al. IMMUNOLOGICAL REVIEWS
- Type I Interferon Signaling Is Decoupled from Specific Receptor Orientation through Lenient Requirements of the Transmembrane Domain
- (2015) Nanaocha Sharma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling
- (2015) Stephan Wilmes et al. JOURNAL OF CELL BIOLOGY
- Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targets
- (2015) Yang Yang et al. Scientific Reports
- Ebola Virus VP24 Targets a Unique NLS Binding Site on Karyopherin Alpha 5 to Selectively Compete with Nuclear Import of Phosphorylated STAT1
- (2014) Wei Xu et al. Cell Host & Microbe
- Triggering ubiquitination of IFNAR1 protects tissues from inflammatory injury
- (2014) S. Bhattacharya et al. EMBO Molecular Medicine
- Enhancedin VivoEfficacy of a Type I Interferon Superagonist with Extended Plasma Half-life in a Mouse Model of Multiple Sclerosis
- (2014) Daniel Harari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- How Type I Interferons Work in Multiple Sclerosis and Other Diseases: Some Unexpected Mechanisms
- (2014) Anthony T. Reder et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Alpha/Beta Interferon Receptor Signaling Amplifies Early Proinflammatory Cytokine Production in the Lung during Respiratory Syncytial Virus Infection
- (2014) M. Goritzka et al. JOURNAL OF VIROLOGY
- Bridging the Species Divide: Transgenic Mice Humanized for Type-I Interferon Response
- (2014) Daniel Harari et al. PLoS One
- Multifaceted Activities of Type I Interferon Are Revealed by a Receptor Antagonist
- (2014) D. Levin et al. Science Signaling
- Mechanisms underlying the inhibition of interferon signaling by viruses
- (2014) Anand S Devasthanam Virulence
- Mechanisms and Implications of Age-Associated Impaired Innate Interferon Secretion by Dendritic Cells: A Mini-Review
- (2013) Anshu Agrawal GERONTOLOGY
- The microRNA miR-155 controls CD8+ T cell responses by regulating interferon signaling
- (2013) Donald T Gracias et al. NATURE IMMUNOLOGY
- Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1
- (2013) Nicole A de Weerd et al. NATURE IMMUNOLOGY
- Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling
- (2013) J. R. Teijaro et al. SCIENCE
- USP18 establishes the transcriptional and anti-proliferative interferon α/β differential
- (2012) Véronique Francois-Newton et al. BIOCHEMICAL JOURNAL
- Understanding cytokine and growth factor receptor activation mechanisms
- (2012) Mariya Atanasova et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Ubiquitination-mediated regulation of interferon responses
- (2012) Serge Y. Fuchs GROWTH FACTORS
- The JAK-STAT Pathway at Twenty
- (2012) George R. Stark et al. IMMUNITY
- Structural and dynamic determinants of type I interferon receptor assembly and their functional interpretation
- (2012) Jacob Piehler et al. IMMUNOLOGICAL REVIEWS
- Sensing of RNA Viruses: a Review of Innate Immune Receptors Involved in Recognizing RNA Virus Invasion
- (2012) S. Jensen et al. JOURNAL OF VIROLOGY
- Decreased interferon-α and interferon-β production in obesity and expression of suppressor of cytokine signaling
- (2012) Eli Teran-Cabanillas et al. NUTRITION
- Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis
- (2012) E Croze et al. PHARMACOGENOMICS JOURNAL
- Coronavirus Papain-like Proteases Negatively Regulate Antiviral Innate Immune Response through Disruption of STING-Mediated Signaling
- (2012) Li Sun et al. PLoS One
- Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons
- (2011) Christoph Thomas et al. CELL
- The Mechanism of Action of Interferon-β in Relapsing Multiple Sclerosis
- (2011) Bernd C. Kieseier CNS DRUGS
- Binding and activity of all human alpha interferon subtypes
- (2011) Thomas B. Lavoie et al. CYTOKINE
- Interferons in Autoimmune and Inflammatory Diseases: Regulation and Roles
- (2011) Divaker Choubey et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Interferon: Current Status and Future Prospects in Cancer Therapy
- (2011) Ben X. Wang et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment
- (2011) D. Levin et al. MOLECULAR AND CELLULAR BIOLOGY
- Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection
- (2010) Tomoki Yoshikawa et al. PLoS One
- Redefining the role of interferon in the treatment of malignant diseases
- (2009) Sergio Bracarda et al. EUROPEAN JOURNAL OF CANCER
- STAT-Phosphorylation–Independent Induction of Interferon Regulatory Factor-9 by Interferon-β
- (2009) M.R. Sandhya Rani et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- The Stability of the Ternary Interferon-Receptor Complex Rather than the Affinity to the Individual Subunits Dictates Differential Biological Activities
- (2008) Eyal Kalie et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- INTERFEROME: the database of interferon regulated genes
- (2008) Shamith A. Samarajiwa et al. NUCLEIC ACIDS RESEARCH
- Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures
- (2007) R. E. Randall et al. JOURNAL OF GENERAL VIROLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started