TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women

A pathogenic role of plasmacytoid dendritic cells in autoimmunity and chronic viral infection

(2019) Franck J. Barrat et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Codon optimality, bias and usage in translation and mRNA decay

(2017) Gavin Hanson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epithelium-innate immune cell axis in mucosal responses to SIV

(2016) L Shang et al.   Mucosal Immunology

Differences in codon bias and GC content contribute to the balanced expression of TLR7 and TLR9

(2016) Zachary R. Newman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated Basal Pre-infection CXCL10 in Plasma and in the Small Intestine after Infection Are Associated with More Rapid HIV/SIV Disease Onset

(2016) Mickaël J. Ploquin et al.   PLoS Pathogens

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-  Production in Women

(2015) M. Griesbeck et al.   JOURNAL OF IMMUNOLOGY

Codon Bias as a Means to Fine-Tune Gene Expression

(2015) Tessa E.F. Quax et al.   MOLECULAR CELL

Structure of the Sec61 channel opened by a signal sequence

(2015) R. M. Voorhees et al.   SCIENCE

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex

(2015) Rebecca M Voorhees et al.   eLife

X-Chromosome Complement and Estrogen Receptor Signaling Independently Contribute to the Enhanced TLR7-Mediated IFN-α Production of Plasmacytoid Dendritic Cells from Women

(2014) Sophie Laffont et al.   JOURNAL OF IMMUNOLOGY

HIV: The mixed blessing of interferon

(2014) Amalio Telenti   NATURE

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

TLR7 induces anergy in human CD4+ T cells

(2014) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

The molecular structure of the left-handed supra-molecular helix of eukaryotic polyribosomes

(2014) Alexander G. Myasnikov et al.   Nature Communications

Plasmacytoid Dendritic Cells Suppress HIV-1 Replication but Contribute to HIV-1 Induced Immunopathogenesis in Humanized Mice

(2014) Guangming Li et al.   PLoS Pathogens

Plasmacytoid Dendritic Cell Dynamics Tune Interferon-Alfa Production in SIV-Infected Cynomolgus Macaques

(2014) Timothée Bruel et al.   PLoS Pathogens

Measurement of average decoding rates of the 61 sense codons in vivo

(2014) Justin Gardin et al.   eLife

Distinct stages of the translation elongation cycle revealed by sequencing ribosome-protected mRNA fragments

(2014) Liana F Lareau et al.   eLife

HIV-1 infection induces strong production of IP-10 through TLR7/9-dependent pathways

(2013) Rachel P. Simmons et al.   AIDS

HIV-associated chronic immune activation

(2013) Mirko Paiardini et al.   IMMUNOLOGICAL REVIEWS

Toll-like Receptor Polymorphism Associations With HIV-1 Outcomes Among Sub-Saharan Africans

(2013) Romel D. Mackelprang et al.   JOURNAL OF INFECTIOUS DISEASES

Toll-Like Receptors in Antiviral Innate Immunity

(2013) Sandra N. Lester et al.   JOURNAL OF MOLECULAR BIOLOGY

Blockade of Chronic Type I Interferon Signaling to Control Persistent LCMV Infection

(2013) E. B. Wilson et al.   SCIENCE

Persistent LCMV Infection Is Controlled by Blockade of Type I Interferon Signaling

(2013) J. R. Teijaro et al.   SCIENCE

MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus

(2013) Yun Deng et al.   PLoS Genetics

Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

(2013) Muhamuda Kader et al.   PLoS Pathogens

UNC93B1 mediates differential trafficking of endosomal TLRs

(2013) Bettina L Lee et al.   eLife

A Role for tRNA Modifications in Genome Structure and Codon Usage

(2012) Eva Maria Novoa et al.   CELL

Trajectory Clustering of Estradiol and Follicle-Stimulating Hormone during the Menopausal Transition among Women in the Study of Women's Health across the Nation (SWAN)

(2012) Ping G. Tepper et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A Real Time Metridia Luciferase Based Non-Invasive Reporter Assay of Mammalian Cell Viability and Cytotoxicity via the β-actin Promoter and Enhancer

(2012) Shawn E. Lupold et al.   PLoS One

Acute Plasma Biomarkers of T Cell Activation Set-Point Levels and of Disease Progression in HIV-1 Infection

(2012) Anne-Sophie Liovat et al.   PLoS One

The effect of HIV infection and HAART on inflammatory biomarkers in a population-based cohort of women

(2011) Sheila M. Keating et al.   AIDS

The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor   signaling

(2011) C. Seillet et al.   BLOOD

Rapid, cell-based toxicity screen of potentially therapeutic post-transcriptional gene silencing agents

(2011) Tiffany A. Kolniak et al.   EXPERIMENTAL EYE RESEARCH

SignalP 4.0: discriminating signal peptides from transmembrane regions

(2011) Thomas Nordahl Petersen et al.   NATURE METHODS

Innate Sensing of HIV-Infected Cells

(2011) Alice Lepelley et al.   PLoS Pathogens

Plasma cytokine levels during acute HIV-1 infection predict HIV disease progression

(2010) Lindi Roberts et al.   AIDS

Early Events in Sexual Transmission of HIV and SIV and Opportunities for Interventions

(2010) Ashley T. Haase   Annual Review of Medicine

Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques

(2010) L. D. Harris et al.   JOURNAL OF VIROLOGY

The mechanism of eukaryotic translation initiation and principles of its regulation

(2010) Richard J. Jackson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A frequent functional toll-like receptor 7 polymorphism is associated with accelerated HIV-1 disease progression

(2009) Djin-Ye Oh et al.   AIDS

Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response

(2009) Béatrice Jacquelin et al.   JOURNAL OF CLINICAL INVESTIGATION

Nonpathogenesis of Simian Immunodeficiency Virus Infection Is Associated with Reduced Inflammation and Recruitment of Plasmacytoid Dendritic Cells to Lymph Nodes, Not to Lack of an Interferon Type I Response, during the Acute Phase

(2009) L. Campillo-Gimenez et al.   JOURNAL OF VIROLOGY

Glycerol monolaurate prevents mucosal SIV transmission

(2009) Qingsheng Li et al.   NATURE

Sex differences in the Toll-like receptor–mediated response of plasmacytoid dendritic cells to HIV-1

(2009) Angela Meier et al.   NATURE MEDICINE

Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense

(2009) Luis B. Barreiro et al.   PLoS Genetics

Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression

(2008) B. Malleret et al.   BLOOD

Why Most Discovered True Associations Are Inflated

(2008) John P. A. Ioannidis   EPIDEMIOLOGY