TLR7 and TLR9 in SLE: when sensing self goes wrong

Expanded Population of Activated Antigen-Engaged Cells within the Naive B Cell Compartment of Patients with Systemic Lupus Erythematosus

(2014) N.-H. Chang et al.   JOURNAL OF IMMUNOLOGY

Malaria Parasites Require TLR9 Signaling for Immune Evasion by Activating Regulatory T Cells

(2014) H. Hisaeda et al.   JOURNAL OF IMMUNOLOGY

Evidence for Genes in Addition to Tlr7 in the Yaa Translocation Linked with Acceleration of Systemic Lupus Erythematosus

(2014) M.-L. Santiago-Raber et al.   JOURNAL OF IMMUNOLOGY

Differential Constitutive and Cytokine-Modulated Expression of Human Toll-like Receptors in Primary Neutrophils, Monocytes, and Macrophages

(2012) D. Shane O'Mahony et al.   International Journal of Medical Sciences

Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells

(2011) C. Russo et al.   BLOOD

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs

(2011) Daniela Hackl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Granulin Is a Soluble Cofactor for Toll-like Receptor 9 Signaling

(2011) Boyoun Park et al.   IMMUNITY

Unc93B1 Restricts Systemic Lethal Inflammation by Orchestrating Toll-like Receptor 7 and 9 Trafficking

(2011) Ryutaro Fukui et al.   IMMUNITY

TLR-induced activation of neutrophils promotes histamine production via a PI3 kinase dependent mechanism

(2011) Craig Smuda et al.   IMMUNOLOGY LETTERS

A novel isoform of the Ly108 gene ameliorates murine lupus

(2011) Marton Keszei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Inhibiting Fc Receptor for IgG, Fc RIIB, Is a Modifier of Autoimmune Susceptibility

(2011) P. Boross et al.   JOURNAL OF IMMUNOLOGY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

LL-37 expression in the skin in systemic lupus erythematosus

(2011) C-L Sun et al.   LUPUS

Genetic predisposition to autoimmunity – What have we learned?

(2011) Ekta Rai et al.   SEMINARS IN IMMUNOLOGY

TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study

(2011) Aya Kawasaki et al.   ARTHRITIS RESEARCH & THERAPY

High mobility group box 1 (HMGB1) and anti-HMGB1 antibodies and their relation to disease characteristics in systemic lupus erythematosus

(2011) Deena A Abdulahad et al.   ARTHRITIS RESEARCH & THERAPY

Mechanisms of B cell autoimmunity in SLE

(2011) Thomas Dörner et al.   ARTHRITIS RESEARCH & THERAPY

Association of TLR7 copy number variation with susceptibility to childhood-onset systemic lupus erythematosus in Mexican population

(2010) H. Garcia-Ortiz et al.   ANNALS OF THE RHEUMATIC DISEASES

Inefficient clearance of dying cells in patients with SLE: anti-dsDNA autoantibodies, MFG-E8, HMGB-1 and other players

(2010) Kristin Kruse et al.   APOPTOSIS

IgG opsonized nuclear remnants from dead cells cause systemic inflammation in SLE

(2010) Luis E. Munoz et al.   AUTOIMMUNITY

Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

(2010) A. Komatsuda et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tolerogenic plasmacytoid DC

(2010) Benjamin M. Matta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

B cells do not take up bacterial DNA: an essential role for antigen in exposure of DNA to toll-like receptor-9

(2010) Tara L Roberts et al.   IMMUNOLOGY AND CELL BIOLOGY

TLR9 Regulates TLR7- and MyD88-Dependent Autoantibody Production and Disease in a Murine Model of Lupus

(2010) Kevin M. Nickerson et al.   JOURNAL OF IMMUNOLOGY

Overexpression of interferon-activated gene 202 (Ifi202) correlates with the progression of autoimmune glomerulonephritis associated with the MRL chromosome 1

(2010) O. Ichii et al.   LUPUS

The interferon-α signature of systemic lupus erythematosus

(2010) G. Obermoser et al.   LUPUS

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Genetic susceptibility to systemic lupus erythematosus in the genomic era

(2010) Yun Deng et al.   Nature Reviews Rheumatology

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA

(2010) J. Martinez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

(2010) A. Hakkim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

(2010) N. Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus

(2010) Ou Jin et al.   ARTHRITIS RESEARCH & THERAPY

Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells

(2009) Z.-j. Pan et al.   ANNALS OF THE RHEUMATIC DISEASES

Remnants of secondarily necrotic cells fuel inflammation in systemic lupus erythematosus

(2009) Luis E. Muñoz et al.   ARTHRITIS AND RHEUMATISM

The geoepidemiology of systemic lupus erythematosus

(2009) Andrea T. Borchers et al.   AUTOIMMUNITY REVIEWS

Low frequency of CD4+CD25+ Treg in SLE patients: a heritable trait associated with CTLA4 and TGFβ gene variants

(2009) Marta Barreto et al.   BMC IMMUNOLOGY

Activation profile of Toll-like receptors of peripheral blood lymphocytes in patients with systemic lupus erythematosus

(2009) C. K. Wong et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The lupus-susceptibility gene kallikrein downmodulates antibody-mediated glomerulonephritis

(2009) Q-Z Li et al.   GENES AND IMMUNITY

Admixture in Hispanic Americans: its impact on ITGAM association and implications for admixture mapping in SLE

(2009) J E Molineros et al.   GENES AND IMMUNITY

Three checkpoints in lupus development: central tolerance in adaptive immunity, peripheral amplification by innate immunity and end-organ inflammation

(2009) H Kanta et al.   GENES AND IMMUNITY

Recent insights into the genetic basis of systemic lupus erythematosus

(2009) K L Moser et al.   GENES AND IMMUNITY

Increase in NF- B Binding Affinity of the Variant C Allele of the Toll-Like Receptor 9 -1237T/C Polymorphism Is Associated with Helicobacter pylori-Induced Gastric Disease

(2009) M. T. H. Ng et al.   INFECTION AND IMMUNITY

Serum DNase I, soluble Fas/FasL levels and cell surface Fas expression in patients with SLE: a possible explanation for the lack of efficacy of hrDNase I treatment

(2009) E. Tinazzi et al.   INTERNATIONAL IMMUNOLOGY

Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice

(2009) Marie-Laure Santiago-Raber et al.   JOURNAL OF AUTOIMMUNITY

Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8

(2009) Dipyaman Ganguly et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing

(2009) Ryutaro Fukui et al.   JOURNAL OF EXPERIMENTAL MEDICINE

LL-37 Promotes Rapid Sensing of CpG Oligodeoxynucleotides by B Lymphocytes and Plasmacytoid Dendritic Cells

(2009) P. Hurtado et al.   JOURNAL OF IMMUNOLOGY

Immunostimulatory RNA Blocks Suppression by Regulatory T Cells

(2009) D. Anz et al.   JOURNAL OF IMMUNOLOGY

Requirement for DNA CpG Content in TLR9-Dependent Dendritic Cell Activation Induced by DNA-Containing Immune Complexes

(2009) K. Yasuda et al.   JOURNAL OF IMMUNOLOGY

DNase 1 activity in patients with systemic lupus erythematosus: relationship with epidemiological, clinical, immunological and therapeutical features

(2009) F Martinez-Valle et al.   LUPUS

Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese

(2009) Chang-Juan Xu et al.   MOLECULAR BIOLOGY REPORTS

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Understanding the Epidemiology and Progression of Systemic Lupus Erythematosus

(2009) Guillermo J. Pons-Estel et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Alarmins link neutrophils and dendritic cells

(2009) De Yang et al.   TRENDS IN IMMUNOLOGY

Comparison of human B cell activation by TLR7 and TLR9 agonists

(2008) John A Hanten et al.   BMC IMMUNOLOGY

Progress in Cationic Lipid-Mediated Gene Transfection: A Series of Bio- Inspired Lipids as an Example

(2008) Tristan Montier et al.   CURRENT GENE THERAPY

Systemic IFN‐α drives kidney nephritis in B6.Sle123mice

(2008) Anna‐Marie Fairhurst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Yaaautoimmune phenotypes are conferred by overexpression of TLR7

(2008) Anna‐Marie Fairhurst et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Lupus-Related Lmb3 Locus Contains a Disease-Suppressing Coronin-1A Gene Mutation

(2008) M. Katarina Haraldsson et al.   IMMUNITY

IRAK-4- and MyD88-Dependent Pathways Are Essential for the Removal of Developing Autoreactive B Cells in Humans

(2008) Isabelle Isnardi et al.   IMMUNITY

The expressions of Toll-like receptor 9 and T-bet in circulating B and T cells in newly diagnosed, untreated systemic lupus erythematosus and correlations with disease activity and laboratory data in a Chinese population

(2008) Ou Wu et al.   IMMUNOBIOLOGY

Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors

(2008) J. Andrew Duty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Live Lactobacillus rhamnosus and Streptococcus pyogenes differentially regulate Toll-like receptor (TLR) gene expression in human primary macrophages

(2008) Minja Miettinen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Altered balance of inhibitory and active Fc gamma receptors in murine autoimmune glomerulonephritis

(2008) Osamu Ichii et al.   KIDNEY INTERNATIONAL