Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones

The Use of Sex-Specific Factors in the Assessment of Women’s Cardiovascular Risk

(2020) Anandita Agarwala et al.   CIRCULATION

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

State of the Science in Women's Cardiovascular Disease: A Canadian Perspective on the Influence of Sex and Gender

(2020) Colleen M. Norris et al.   Journal of the American Heart Association

COVID-19, ACE2, and the cardiovascular consequences

(2020) Andrew M. South et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The ACE2 expression in human heart indicates new potential mechanism of heart injury among patients infected with SARS-CoV-2

(2020) Liang Chen et al.   CARDIOVASCULAR RESEARCH

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

The Variety of Cardiovascular Presentations of COVID-19

(2020) Justin A. Fried et al.   CIRCULATION

Angiotensin Converting Enzyme 2: A Double-Edged Sword

(2020) Kaiming Wang et al.   CIRCULATION

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System

(2020) Mahmoud Gheblawi et al.   CIRCULATION RESEARCH

Plasma angiotensin-converting enzyme 2: novel biomarker in heart failure with implications for COVID-19

(2020) Gavin Y Oudit et al.   EUROPEAN HEART JOURNAL

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

(2020) Maximilian Ackermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study

(2020) Shufa Zheng et al.   BMJ-British Medical Journal

Sex-Specific Modulation of Blood Pressure and the Renin-Angiotensin System by ACE (Angiotensin-Converting Enzyme) 2

(2020) Hong Ji et al.   HYPERTENSION

COVID-19

(2020) Paolo Verdecchia et al.   HYPERTENSION

Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2

(2020) Stepan Nersisyan et al.   PLoS One

Interplay between SARS-CoV-2 and the type I interferon response

(2020) Margarida Sa Ribero et al.   PLoS Pathogens

ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases

(2020) Ravindra K. Sharma et al.   HYPERTENSION

Sex differences in immune responses that underlie COVID-19 disease outcomes

(2020) Takehiro Takahashi et al.   NATURE

An inflammatory cytokine signature predicts COVID-19 severity and survival

(2020) Diane Marie Del Valle et al.   NATURE MEDICINE

Heart failure drug treatment

(2019) Patrick Rossignol et al.   LANCET

Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study

(2019) Bernadet T Santema et al.   LANCET

Sex differences in cardiometabolic disorders

(2019) Eva Gerdts et al.   NATURE MEDICINE

Sex Differences in the Presentation and Perception of Symptoms Among Young Patients With Myocardial Infarction

(2018) Judith H. Lichtman et al.   CIRCULATION

Sex Differences in Cardiovascular Pathophysiology

(2018) Anna L. Beale et al.   CIRCULATION

Sex differences in heart failure

(2018) Evann Eisenberg et al.   CLINICAL CARDIOLOGY

Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection

(2017) Rudragouda Channappanavar et al.   JOURNAL OF IMMUNOLOGY

Landscape of X chromosome inactivation across human tissues

(2017) Taru Tukiainen et al.   NATURE

Role of the ACE2/Angiotensin 1–7 Axis of the Renin–Angiotensin System in Heart Failure

(2016) Vaibhav B. Patel et al.   CIRCULATION RESEARCH

Sex-Specific Changes in Renal Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression and Enzyme Activity at Birth and Over the First Year of Life

(2015) Kai Chen et al.   Reproductive Sciences

Angiotensin-Converting Enzyme 2 Is a Critical Determinant of Angiotensin II–Induced Loss of Vascular Smooth Muscle Cells and Adverse Vascular Remodeling

(2014) Vaibhav B. Patel et al.   HYPERTENSION

Heterozygote loss of ACE2 is sufficient to increase the susceptibility to heart disease

(2014) Wang Wang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Update on the Angiotensin Converting Enzyme 2-Angiotensin (1–7)-Mas Receptor Axis: Fetal Programing, Sex Differences, and Intracellular Pathways

(2014) Mark C. Chappell et al.   Frontiers in Endocrinology

Angiotensin II induced proteolytic cleavage of myocardial ACE2 is mediated by TACE/ADAM-17: A positive feedback mechanism in the RAS

(2013) Vaibhav B. Patel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Angiotensin Converting Enzyme 2 Contributes to Sex Differences in the Development of Obesity Hypertension in C57BL/6 Mice

(2012) Manisha Gupte et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SARS coronavirus pathogenesis: host innate immune responses and viral antagonism of interferon

(2012) Allison L Totura et al.   Current Opinion in Virology

The Emerging Role of Innate Immunity in the Heart and Vascular System

(2011) Douglas L. Mann   CIRCULATION RESEARCH

Angiotensin-(1-7) Blockade Attenuates Captopril- or Hydralazine-induced Cardiovascular Protection in Spontaneously Hypertensive Rats Treated With NG-nitro-l-Arginine Methyl Ester

(2011) Ibrahim F Benter et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Elevated 17β-Estradiol Protects Females from Influenza A Virus Pathogenesis by Suppressing Inflammatory Responses

(2011) Dionne P. Robinson et al.   PLoS Pathogens

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Sex differences in renal angiotensin converting enzyme 2 (ACE2) activity are 17β-oestradiol-dependent and sex chromosome-independent

(2010) Jun Liu et al.   Biology of Sex Differences

Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17β-oestradiol regulation of renal pathology in renal wrap hypertension in rats

(2008) Hong Ji et al.   EXPERIMENTAL PHYSIOLOGY

Modulation of TNF- -converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-  production and facilitates viral entry

(2008) S. Haga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

(2007) Jennifer A. Rettew et al.   BIOLOGY OF REPRODUCTION

Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats

(2007) Michele F. Hannah et al.   BRAIN BEHAVIOR AND IMMUNITY