X-chromosome inactivation and escape

Systematic Discovery of Xist RNA Binding Proteins

(2015) Ci Chu et al.   CELL

Erosion of X Chromosome Inactivation in Human Pluripotent Cells Initiates with XACT Coating and Depends on a Specific Heterochromatin Landscape

(2015) Céline Vallot et al.   Cell Stem Cell

X-chromosome inactivation: new insights into cis and trans regulation

(2015) Rafael Galupa et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Microdeletion of the escape genes KDM5C and IQSEC2 in a girl with severe intellectual disability and autistic features

(2015) Nathalie Fieremans et al.   European Journal of Medical Genetics

The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer

(2015) Ronan Chaligné et al.   GENOME RESEARCH

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

Human body epigenome maps reveal noncanonical DNA methylation variation

(2015) Matthew D. Schultz et al.   NATURE

The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells

(2015) Hongjae Sunwoo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosome X genomic and epigenomic aberrations and clinical implications in breast cancer by base resolution profiling

(2015) Zhifu Sun et al.   Epigenomics

A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation

(2015) Srimonta Gayen et al.   Cell Reports

Escape from X Inactivation Varies in Mouse Tissues

(2015) Joel B. Berletch et al.   PLoS Genetics

The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation

(2015) Fan Yang et al.   GENOME BIOLOGY

Noncoding RNAs and Epigenetic Mechanisms During X-Chromosome Inactivation

(2014) Anne-Valerie Gendrel et al.   Annual Review of Cell and Developmental Biology

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia

(2014) Joni Van der Meulen et al.   BLOOD

Predictive Polymer Modeling Reveals Coupled Fluctuations in Chromosome Conformation and Transcription

(2014) Luca Giorgetti et al.   CELL

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

Nucleolus and nuclear periphery: Velcro for heterochromatin

(2014) Jan Padeken et al.   CURRENT OPINION IN CELL BIOLOGY

Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta

(2014) Elizabeth H. Finn et al.   DEVELOPMENTAL BIOLOGY

Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation

(2014) Allison M. Cotton et al.   HUMAN MOLECULAR GENETICS

Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators

(2014) Daniel W. Bellott et al.   NATURE

Origins and functional evolution of Y chromosomes across mammals

(2014) Diego Cortez et al.   NATURE

X chromosome regulation: diverse patterns in development, tissues and disease

(2014) Xinxian Deng et al.   NATURE REVIEWS GENETICS

Cellular Resolution Maps of X Chromosome Inactivation: Implications for Neural Development, Function, and Disease

(2014) Hao Wu et al.   NEURON

Derivation of naive human embryonic stem cells

(2014) C. B. Ware et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

X Chromosome Inactivation and Epigenetic Responses to Cellular Reprogramming

(2013) Derek Lessing et al.   Annual Review of Genomics and Human Genetics

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice

(2013) Eda Yildirim et al.   CELL

Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells

(2013) C. Corbel et al.   DEVELOPMENT

Haploinsufficiency of KDM6A is associated with severe psychomotor retardation, global growth restriction, seizures and cleft palate

(2013) Amelia M. Lindgren et al.   HUMAN GENETICS

High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation

(2013) Matthew D. Simon et al.   NATURE

Translating dosage compensation to trisomy 21

(2013) Jun Jiang et al.   NATURE

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

The Xist lncRNA Exploits Three-Dimensional Genome Architecture to Spread Across the X Chromosome

(2013) J. M. Engreitz et al.   SCIENCE

Female Bias in Rhox6 and 9 Regulation by the Histone Demethylase KDM6A

(2013) Joel B. Berletch et al.   PLoS Genetics

Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome

(2013) Allison M Cotton et al.   GENOME BIOLOGY

Dosage Compensation of the Sex Chromosomes

(2012) Christine M. Disteche   Annual Review of Genetics

Site-Specific Silencing of Regulatory Elements as a Mechanism of X Inactivation

(2012) J. Mauro Calabrese et al.   CELL

Reactivation of the inactive X chromosome in development and reprogramming

(2012) Tatsuya Ohhata et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Smchd1-Dependent and -Independent Pathways Determine Developmental Dynamics of CpG Island Methylation on the Inactive X Chromosome

(2012) Anne-Valerie Gendrel et al.   DEVELOPMENTAL CELL

Nonrandom X Chromosome Inactivation Is Influenced by Multiple Regions on the Murine X Chromosome

(2012) J. L. Thorvaldsen et al.   GENETICS

Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations

(2012) S. F. Pinter et al.   GENOME RESEARCH

The macrosatellite DXZ4 mediates CTCF-dependent long-range intrachromosomal interactions on the human inactive X chromosome

(2012) Andrea H. Horakova et al.   HUMAN MOLECULAR GENETICS

KDM6A Point Mutations Cause Kabuki Syndrome

(2012) Noriko Miyake et al.   HUMAN MUTATION

RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation

(2012) Cristina Gontan et al.   NATURE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Escape from X inactivation in mice and humans

(2012) Joel B Berletch et al.   GENOME BIOLOGY

The mouse DXZ4 homolog retains Ctcf binding and proximity to Pls3 despite substantial organizational differences compared to the primate macrosatellite

(2012) Andrea H Horakova et al.   GENOME BIOLOGY

Deletion of KDM6A, a Histone Demethylase Interacting with MLL2, in Three Patients with Kabuki Syndrome

(2011) Damien Lederer et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetics and epigenetics of the X chromosome

(2011) Céline Morey et al.   Annals of the New York Academy of Sciences

The inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA

(2011) E. Splinter et al.   GENES & DEVELOPMENT

Genes that escape from X inactivation

(2011) Joel B. Berletch et al.   HUMAN GENETICS

Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development

(2011) Ikuhiro Okamoto et al.   NATURE

Derivation of haploid embryonic stem cells from mouse embryos

(2011) Martin Leeb et al.   NATURE

Relative overexpression of X-linked genes in mouse embryonic stem cells is consistent with Ohno's hypothesis

(2011) Hong Lin et al.   NATURE GENETICS

A novel nonsense mutation in KDM5C/JARID1C gene causing intellectual disability, short stature and speech delay

(2011) Cíntia B. Santos-Rebouças et al.   NEUROSCIENCE LETTERS

Identification of regulatory elements flanking human XIST reveals species differences

(2010) Samuel C Chang et al.   BMC MOLECULAR BIOLOGY

LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation

(2010) Jennifer C. Chow et al.   CELL

The Matrix Protein hnRNP U Is Required for Chromosomal Localization of Xist RNA

(2010) Yuko Hasegawa et al.   DEVELOPMENTAL CELL

Global survey of escape from X inactivation by RNA-sequencing in mouse

(2010) F. Yang et al.   GENOME RESEARCH

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

(2010) Gillian L. Dalgliesh et al.   NATURE

A review of trisomy X (47,XXX)

(2010) Nicole R Tartaglia et al.   Orphanet Journal of Rare Diseases

Efficiency of Xist-mediated silencing on autosomes is linked to chromosomal domain organisation

(2010) Y Amy Tang et al.   Epigenetics & Chromatin

High-resolution analysis of epigenetic changes associated with X inactivation

(2009) H. Marks et al.   GENOME RESEARCH

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

(2009) Gijs van Haaften et al.   NATURE GENETICS

X Chromosome Dosage Compensation: How Mammals Keep the Balance

(2008) Bernhard Payer et al.   Annual Review of Genetics

X Inactivation Counting and Choice Is a Stochastic Process: Evidence for Involvement of an X-Linked Activator

(2008) Kim Monkhorst et al.   CELL

DXZ4 chromatin adopts an opposing conformation to that of the surrounding chromosome and acquires a novel inactive X-specific role involving CTCF and antisense transcripts

(2008) B. P. Chadwick   GENOME RESEARCH

Molecular Coupling of Xist Regulation and Pluripotency

(2008) P. Navarro et al.   SCIENCE