Type I Interferon and the Spectrum of Susceptibility to Viral Infection and Autoimmune Disease: A Shared Genomic Signature

TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons

(2021) Daxing Gao et al.   JOURNAL OF CLINICAL INVESTIGATION

Epstein-Barr Virus and Systemic Autoimmune Diseases

(2021) Gunnar Houen et al.   Frontiers in Immunology

A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity

(2021) Sirui Zhou et al.   NATURE MEDICINE

Investigation of type I interferon responses in ANCA-associated vasculitis

(2021) Isabella Batten et al.   Scientific Reports

From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio

(2021) Lisa M. Arkin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Mapping the human genetic architecture of COVID-19

(2021)   NATURE

Endomembrane targeting of human OAS1 p46 augments antiviral activity

(2021) Frank W Soveg et al.   eLife

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

(2021) Evangelos Andreakos et al.   NATURE IMMUNOLOGY

Broad immune activation underlies shared set point signatures for vaccine responsiveness in healthy individuals and disease activity in patients with lupus

(2020) Yuri Kotliarov et al.   NATURE MEDICINE

Positive results for anifrolumab in phase III SLE trial

(2020) Sarah Onuora   Nature Reviews Rheumatology

Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

(2020) Zhi Li et al.   PLoS One

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

(2020) Jean-Laurent Casanova et al.   CELL

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Independent Replication on Genome-Wide Association Study Signals Identifies IRF3 as a Novel Locus for Systemic Lupus Erythematosus

(2020) Feixia Zhang et al.   Frontiers in Genetics

TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women

(2020) Pascal Azar et al.   JCI Insight

Early type I IFN blockade improves the efficacy of viral vaccines

(2020) Nicole Palacio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structural integrity with functional plasticity: what type I IFN receptor polymorphisms reveal

(2020) Nicole A. Weerd et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Natural killer cell phenotype is altered in HIV-exposed seronegative women

(2020) Nancy Q. Zhao et al.   PLoS One

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

Homozygosity for TYK2 P1104A underlies tuberculosis in about 1% of patients in a cohort of European ancestry

(2019) Gaspard Kerner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA sensing by the cGAS–STING pathway in health and disease

(2019) Mona Motwani et al.   NATURE REVIEWS GENETICS

Conservation, acquisition, and functional impact of sex-biased gene expression in mammals

(2019) Sahin Naqvi et al.   SCIENCE

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

(2019) Krist Helen Antunes et al.   Nature Communications

Interferon-Stimulated Genes: What Do They All Do?

(2019) John W. Schoggins   Annual Review of Virology

Sources of Type I Interferons in Infectious Immunity: Plasmacytoid Dendritic Cells Not Always in the Driver's Seat

(2019) Shafaqat Ali et al.   Frontiers in Immunology

Ensembl 2020

(2019) Andrew D Yates et al.   NUCLEIC ACIDS RESEARCH

Publisher Correction: Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

(2018) Etienne Patin et al.   NATURE IMMUNOLOGY

A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans

(2018) Guoliang Zhang et al.   Nature Communications

The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells

(2018) C. Enerbäck et al.   Scientific Reports

Evidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans

(2018) David Enard et al.   CELL

The role of sex in the genomics of human complex traits

(2018) Ekaterina A. Khramtsova et al.   NATURE REVIEWS GENETICS

Monogenic Lupus: A Developing Paradigm of Disease

(2018) Jessie M. Alperin et al.   Frontiers in Immunology

Detection of interferon alpha protein reveals differential levels and cellular sources in disease

(2017) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exploration of potential mechanisms of hepatitis C virus resistance in exposed uninfected intravenous drug users

(2017) I. T. Shawa et al.   JOURNAL OF VIRAL HEPATITIS

Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

(2017) Barbara Piasecka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-specific effects of TLR9 promoter variants on spontaneous clearance of HCV infection

(2016) Janett Fischer et al.   GUT

Association analysis of class II cytokine and receptor genes in vitiligo patients

(2016) Tanel Traks et al.   HUMAN IMMUNOLOGY

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

(2016) Duojiao Wu et al.   IMMUNITY

Influence ofTYK2in systemic sclerosis susceptibility: a newlocusin the IL-12 pathway

(2015) Elena López-Isac et al.   ANNALS OF THE RHEUMATIC DISEASES

Functional IRF3 deficiency in a patient with herpes simplex encephalitis

(2015) Line Lykke Andersen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-  Production in Women

(2015) M. Griesbeck et al.   JOURNAL OF IMMUNOLOGY

Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies

(2015) Judy H Cho et al.   NATURE MEDICINE

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

Dynamic control of type I IFN signalling by an integrated network of negative regulators

(2015) Rebecca A. Porritt et al.   TRENDS IN IMMUNOLOGY

Polymorphisms in the TLR3 gene are associated with risk for type 1 diabetes mellitus

(2014) Taís Silveira Assmann et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Gender differences in autoimmune disease

(2014) S.T. Ngo et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Dual Regulatory Roles of Phosphatidylinositol 3-Kinase in IFN Signaling

(2014) S. Kaur et al.   JOURNAL OF IMMUNOLOGY

Global Epidemiology of Tuberculosis

(2014) P. Glaziou et al.   Cold Spring Harbor Perspectives in Medicine

Type I Interferon in Human Autoimmunity

(2014) Timothy B. Niewold   Frontiers in Immunology

The Toll-like Receptor 3 L412F Polymorphism and Disease Progression in Idiopathic Pulmonary Fibrosis

(2013) David N. O’Dwyer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hepatitis C virus targets the interferon-α JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes

(2013) Nigel J. Stevenson et al.   FEBS LETTERS

Polymorphisms within Toll-like receptors are associated with systemic lupus erythematosus in a cohort of Danish females

(2013) Magdalena Janina Laska et al.   RHEUMATOLOGY

The ribonucleasel-dependent antiviral roles of human 2′,5′-oligoadenylate synthetase family members against hepatitis C virus

(2012) Young-Chan Kwon et al.   FEBS LETTERS

Cytokine profiles in high risk injection drug users suggests innate as opposed to adaptive immunity in apparent resistance to hepatitis C virus infection

(2012) U. M. Warshow et al.   JOURNAL OF VIRAL HEPATITIS

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Genetic associations in type I interferon related pathways with autoimmunity

(2012) Angélica M Delgado-Vega et al.   ARTHRITIS RESEARCH & THERAPY

Identification of a new susceptibility variant for multiple sclerosis in OAS1 by population genetics analysis

(2011) Rachele Cagliani et al.   HUMAN GENETICS

Sex differences in disease risk from reported genome-wide association study findings

(2011) Linda Y. Liu et al.   HUMAN GENETICS

A Common Polymorphism in TLR3 Confers Natural Resistance to HIV-1 Infection

(2011) M. Sironi et al.   JOURNAL OF IMMUNOLOGY

Impaired type I and III interferon response to rhinovirus infection during pregnancy and asthma

(2011) Rebecca Louise Forbes et al.   THORAX

Correction: Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Pressure through Human Evolution

(2011) Matteo Fumagalli et al.   PLoS Genetics

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Single nucleotide polymorphism at exon 7 splice acceptor site of OAS1 gene determines response of hepatitis C virus patients to interferon therapy

(2010) Mostafa K El Awady et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

OAS1: A multiple sclerosis susceptibility gene that influences disease severity

(2010) M. O'Brien et al.   NEUROLOGY

Role of Inflammation Gene Polymorphisms on Pain Severity in Lung Cancer Patients

(2009) C. C. Reyes-Gibby et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Reassessment of the type I diabetes association of the OAS1 locus

(2009) H-Q Qu et al.   GENES AND IMMUNITY

Strong Evidence of a Combination Polymorphism of the Tyrosine Kinase 2 Gene and the Signal Transducer and Activator of Transcription 3 Gene as a DNA-Based Biomarker for Susceptibility to Crohn’s Disease in the Japanese Population

(2009) Kayoko Sato et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Functional dissection of an IFN-α/β receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection

(2009) Jie Zhou et al.   JOURNAL OF HEPATOLOGY

From evolutionary genetics to human immunology: how selection shapes host defence genes

(2009) Luis B. Barreiro et al.   NATURE REVIEWS GENETICS

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man

(2009) Jean K. Lim et al.   PLoS Pathogens

Common Variants in Immune and DNA Repair Genes and Risk for Human Papillomavirus Persistence and Progression to Cervical Cancer

(2008) Sophia S. Wang et al.   JOURNAL OF INFECTIOUS DISEASES