Functional IRF3 deficiency in a patient with herpes simplex encephalitis

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

OutKnocker: a web tool for rapid and simple genotyping of designer nuclease edited cell lines

(2014) Jonathan L. Schmid-Burgk et al.   GENOME RESEARCH

Guidelines for genetic studies in single patients: lessons from primary immunodeficiencies

(2014) Jean-Laurent Casanova et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR3 deficiency in herpes simplex encephalitis: High allelic heterogeneity and recurrence risk

(2014) H. K. Lim et al.   NEUROLOGY

Autoimmunity by haploinsufficiency

(2014) F. Rieux-Laucat et al.   SCIENCE

TLR3 immunity to infection in mice and humans

(2013) Shen-Ying Zhang et al.   CURRENT OPINION IN IMMUNOLOGY

Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP

(2013) Andrea Ablasser et al.   NATURE

Data, information, knowledge and principle: back to metabolism in KEGG

(2013) Minoru Kanehisa et al.   NUCLEIC ACIDS RESEARCH

HeterozygousTBK1mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

(2012) Melina Herman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells

(2012) Fabien G. Lafaille et al.   NATURE

NEMO is a key component of NF-κB– and IRF-3–dependent TLR3-mediated immunity to herpes simplex virus

(2011) Magali Audry et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Herpes simplex encephalitis in children with autosomal recessive and dominant TRIF deficiency

(2011) Vanessa Sancho-Shimizu et al.   JOURNAL OF CLINICAL INVESTIGATION

Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity

(2011) Yiqi Guo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inborn errors of anti-viral interferon immunity in humans

(2011) Vanessa Sancho-Shimizu et al.   Current Opinion in Virology

Human TRAF3 Adaptor Molecule Deficiency Leads to Impaired Toll-like Receptor 3 Response and Susceptibility to Herpes Simplex Encephalitis

(2010) Rebeca Pérez de Diego et al.   IMMUNITY

Age-Dependent Mendelian Predisposition to Herpes Simplex Virus Type 1 Encephalitis in Childhood

(2010) Laurent Abel et al.   JOURNAL OF PEDIATRICS

Interferon Regulatory Factor 3-Dependent Pathways Are Critical for Control of Herpes Simplex Virus Type 1 Central Nervous System Infection

(2010) V. D. Menachery et al.   JOURNAL OF VIROLOGY

Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses

(2009) T. H. Mogensen   CLINICAL MICROBIOLOGY REVIEWS

Amelioration of Psoriasis by Anti-TNF-α RNAi in the Xenograft Transplantation Model

(2009) Maria Jakobsen et al.   MOLECULAR THERAPY