A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection

Adaptive immunity to SARS-CoV-2 and COVID-19

(2021) Alessandro Sette et al.   CELL

Human ancient DNA analyses reveal the high burden of tuberculosis in Europeans over the last 2,000 years

(2021) Gaspard Kerner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association between ABO blood types and coronavirus disease 2019 (COVID-19), genetic associations, and underlying molecular mechanisms: a literature review of 23 studies

(2021) Yujia Zhang et al.   ANNALS OF HEMATOLOGY

Plasma Exchange to Rescue Patients with Autoantibodies Against Type I Interferons and Life-Threatening COVID-19 Pneumonia

(2021) Nicolas de Prost et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Auto-antibodies to type I IFNs can underlie adverse reactions to yellow fever live attenuated vaccine

(2021) Paul Bastard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High infection secondary attack rates of SARS-CoV-2 in Dutch households revealed by dense sampling

(2021) Daphne F M Reukers et al.   CLINICAL INFECTIOUS DISEASES

Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients

(2021) Rutger Koning et al.   INTENSIVE CARE MEDICINE

Neutralizing Autoantibodies to Type I Interferons in COVID-19 Convalescent Donor Plasma

(2021) Sara E. Vazquez et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Neutralizing Autoantibodies to Type I IFNs in >10% of Patients with Severe COVID-19 Pneumonia Hospitalized in Madrid, Spain

(2021) Jesús Troya et al.   JOURNAL OF CLINICAL IMMUNOLOGY

SARS-CoV-2–related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

(2021) Vanessa Sancho-Shimizu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Trans-ancestry analysis reveals genetic and nongenetic associations with COVID-19 susceptibility and severity

(2021) Janie F. Shelton et al.   NATURE GENETICS

Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

(2021) Kushal Suryamohan et al.   Communications Biology

Household transmission of SARS-CoV-2 in the United States: living density, viral load, and disproportionate impact on communities of color

(2021) Carla Cerami et al.   CLINICAL INFECTIOUS DISEASES

An ancient viral epidemic involving host coronavirus interacting genes more than 20,000 years ago in East Asia

(2021) Yassine Souilmi et al.   CURRENT BIOLOGY

Mapping the human genetic architecture of COVID-19

(2021)   NATURE

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

(2021) Monique G. P. van der Wijst et al.   Science Translational Medicine

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

(2021) Paul Bastard et al.   Science Immunology

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

(2021) Takaki Asano et al.   Science Immunology

The monogenic basis of human tuberculosis

(2020) Stephanie Boisson-Dupuis   HUMAN GENETICS

Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in Wuhan, China: a modelling study

(2020) Joseph T Wu et al.   LANCET

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia

(2020) Qun Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lethal Infectious Diseases as Inborn Errors of Immunity: Toward a Synthesis of the Germ and Genetic Theories

(2020) Jean-Laurent Casanova et al.   Annual Review of Pathology-Mechanisms of Disease

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

(2020) Jean-Laurent Casanova et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Pernio-like skin lesions associated with COVID-19: a case series of 318 patients from 8 countries

(2020) Esther E. Freeman et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Mild or Moderate Covid-19

(2020) Rajesh T. Gandhi et al.   NEW ENGLAND JOURNAL OF MEDICINE

SARS‐CoV‐2 endothelial infection causes COVID‐19 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases

(2020) I. Colmenero et al.   BRITISH JOURNAL OF DERMATOLOGY

Super-spreading events and contribution to transmission of MERS, SARS, and SARS-CoV-2 (COVID-19)

(2020) J.A. Al-Tawfiq et al.   JOURNAL OF HOSPITAL INFECTION

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

(2020) Julian Braun et al.   NATURE

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Genomewide Association Study of Severe Covid-19 with Respiratory Failure

(2020) David Ellinghaus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Common homozygosity for predicted loss-of-function variants reveals both redundant and advantageous effects of dispensable human genes

(2020) Antonio Rausell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans

(2020) Jose Mateus et al.   SCIENCE

Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19

(2020) Takuya Sekine et al.   CELL

Identification of required host factors for SARS-CoV-2 infection in human cells

(2020) Zharko Daniloski et al.   CELL

Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection

(2020) Jin Wei et al.   CELL

Emerging Pandemic Diseases: How We Got to COVID-19

(2020) David M. Morens et al.   CELL

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

(2020) David E. Gordon et al.   SCIENCE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses

(2020) Ruofan Wang et al.   CELL

Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks

(2020) William M. Schneider et al.   CELL

TMEM41B Is a Pan-flavivirus Host Factor

(2020) H.-Heinrich Hoffmann et al.   CELL

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

(2020) H.-Heinrich Hoffmann et al.   Cell Host & Microbe

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

(2020) Ioanna-Evdokia Galani et al.   NATURE IMMUNOLOGY

Household Transmission of SARS-CoV-2

(2020) Zachary J. Madewell et al.   JAMA Network Open

HIV-1 remission following CCR5Δ32/Δ32 haematopoietic stem-cell transplantation

(2019) Ravindra K. Gupta et al.   NATURE

Human Immunology through the Lens of Evolutionary Genetics

(2019) Lluis Quintana-Murci   CELL

Homozygosity for TYK2 P1104A underlies tuberculosis in about 1% of patients in a cohort of European ancestry

(2019) Gaspard Kerner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives

(2018) Laurent Abel et al.   LANCET INFECTIOUS DISEASES

Evidence that RNA Viruses Drove Adaptive Introgression between Neanderthals and Modern Humans

(2018) David Enard et al.   CELL

Exome and genome sequencing for inborn errors of immunity

(2016) Isabelle Meyts et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Viruses are a dominant driver of protein adaptation in mammals

(2016) David Enard et al.   eLife

Human TYK2 deficiency: Mycobacterial and viral infections without hyper-IgE syndrome

(2015) Alexandra Y. Kreins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-12Rβ1 Deficiency in Two of Fifty Children with Severe Tuberculosis from Iran, Morocco, and Turkey

(2011) Stéphanie Boisson-Dupuis et al.   PLoS One

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

Genetic variation in IL28B and spontaneous clearance of hepatitis C virus

(2009) David L. Thomas et al.   NATURE

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE