The psoriasis-protective TYK2 I684S variant impairs IL-12 stimulated pSTAT4 response in skin-homing CD4+ and CD8+ memory T-cells

IFN-γ and TNF-α synergism may provide a link between psoriasis and inflammatory atherogenesis

(2017) Nehal N. Mehta et al.   Scientific Reports

Targeting cytokine signaling in autoimmunity: back to the future and beyond

(2016) Kiyoshi Hirahara et al.   CURRENT OPINION IN IMMUNOLOGY

Association between TYK2 polymorphisms and susceptibility to autoimmune rheumatic diseases: a meta-analysis

(2016) Y H Lee et al.   LUPUS

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

(2016) C. A. Dendrou et al.   Science Translational Medicine

Influence ofTYK2in systemic sclerosis susceptibility: a newlocusin the IL-12 pathway

(2015) Elena López-Isac et al.   ANNALS OF THE RHEUMATIC DISEASES

The Immunopathogenesis of Psoriasis

(2015) Jaehwan Kim et al.   DERMATOLOGIC CLINICS

Genetic association and interaction between the IRF5 and TYK2 genes and systemic lupus erythematosus in the Han Chinese population

(2015) Liang Tang et al.   INFLAMMATION RESEARCH

Analysis of long non-coding RNAs highlights tissue-specific expression patterns and epigenetic profiles in normal and psoriatic skin

(2015) Lam C Tsoi et al.   GENOME BIOLOGY

TYK2 Promoter Variant and Diabetes Mellitus in the Japanese

(2015) Seiho Nagafuchi et al.   EBioMedicine

Immunology of Psoriasis

(2014) Michelle A. Lowes et al.   Annual Review of Immunology

The molecular regulation of Janus kinase (JAK) activation

(2014) Jeffrey J. Babon et al.   BIOCHEMICAL JOURNAL

Transcriptome Analysis of Psoriasis in a Large Case–Control Sample: RNA-Seq Provides Insights into Disease Mechanisms

(2014) Bingshan Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structural basis of recognition of interferon-α receptor by tyrosine kinase 2

(2014) Heidi J A Wallweber et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two Rare Disease-Associated Tyk2 Variants Are Catalytically Impaired but Signaling Competent

(2013) Z. Li et al.   JOURNAL OF IMMUNOLOGY

A Restricted Role for TYK2 Catalytic Activity in Human Cytokine Responses Revealed by Novel TYK2-Selective Inhibitors

(2013) S. J. Sohn et al.   JOURNAL OF IMMUNOLOGY

Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci

(2012) David Ellinghaus et al.   AMERICAN JOURNAL OF HUMAN GENETICS

JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease

(2012) John J. O'Shea et al.   IMMUNITY

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

(2012) Lam C Tsoi et al.   NATURE GENETICS

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

(2011) N. Couturier et al.   BRAIN

Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with Systemic Lupus Erythematosus

(2011) Deborah S. Cunninghame Graham et al.   PLoS Genetics

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

(2010) Amy Strange et al.   NATURE GENETICS

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis

(2009) Inger-Lise Mero et al.   EUROPEAN JOURNAL OF HUMAN GENETICS