Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

Living in an adaptive world: Genomic dissection of the genusHomoand its immune response

(2017) Hélène Quach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Multicenter Systems Analysis of Human Blood Reveals Immature Neutrophils in Males and During Pregnancy

(2017) Jana Blazkova et al.   JOURNAL OF IMMUNOLOGY

Continuous immunotypes describe human immune variation and predict diverse responses

(2017) Kevin J. Kaczorowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations

(2017) Sarah Kim-Hellmuth et al.   Nature Communications

Host and Environmental Factors Influencing Individual Human Cytokine Responses

(2016) Rob ter Horst et al.   CELL

Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens

(2016) Yohann Nédélec et al.   CELL

Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations

(2016) Hélène Quach et al.   CELL

A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans

(2016) Yang Li et al.   CELL

Impact of the X Chromosome and sex on regulatory variation

(2016) Kimberly R. Kukurba et al.   GENOME RESEARCH

Adjuvanted influenza-H1N1 vaccination reveals lymphoid signatures of age-dependent early responses and of clinical adverse events

(2016) Olga Sobolev et al.   NATURE IMMUNOLOGY

The cellular composition of the human immune system is shaped by age and cohabitation

(2016) Edward J Carr et al.   NATURE IMMUNOLOGY

Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi

(2016) Yang Li et al.   NATURE MEDICINE

RNA splicing is a primary link between genetic variation and disease

(2016) Yang I. Li et al.   SCIENCE

Shaping Variation in the Human Immune System

(2016) Adrian Liston et al.   TRENDS IN IMMUNOLOGY

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

(2016) Alejandra Urrutia et al.   Cell Reports

Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits

(2016) Raul Aguirre-Gamboa et al.   Cell Reports

SeXX Matters in Infectious Disease Pathogenesis

(2016) Landon G. vom Steeg et al.   PLoS Pathogens

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

(2016) Shai S. Shen-Orr et al.   Cell Systems

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis

(2015) Mario Roederer et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

The Milieu Intérieur study — An integrative approach for study of human immunological variance

(2015) Stéphanie Thomas et al.   CLINICAL IMMUNOLOGY

Semi-automated and standardized cytometric procedures for multi-panel and multi-parametric whole blood immunophenotyping

(2015) Milena Hasan et al.   CLINICAL IMMUNOLOGY

Reference intervals for leukocyte subsets in adults: Results from a population-based study using 10-color flow cytometry

(2015) Susanne Melzer et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

(2015) James Bentham et al.   NATURE GENETICS

Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy

(2015) Hong Liu et al.   NATURE GENETICS

The role of regulatory variation in complex traits and disease

(2015) Frank W. Albert et al.   NATURE REVIEWS GENETICS

ImmVar project: Insights and design considerations for future studies of “healthy” immune variation

(2015) Philip L. De Jager et al.   SEMINARS IN IMMUNOLOGY

The transcriptional landscape of age in human peripheral blood

(2015) Marjolein J. Peters et al.   Nature Communications

Genomic modulators of gene expression in human neutrophils

(2015) Vivek Naranbhai et al.   Nature Communications

Expression quantitative trait locus analysis for translational medicine

(2015) Greg Gibson et al.   Genome Medicine

Host Genetic Variation Influences Gene Expression Response to Rhinovirus Infection

(2015) Minal Çalışkan et al.   PLoS Genetics

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging

(2015) Chan C. Whiting et al.   PLoS One

Joint Analysis of Functional Genomic Data and Genome-wide Association Studies of 18 Human Traits

(2014) Joseph K. Pickrell   AMERICAN JOURNAL OF HUMAN GENETICS

Sex differences in the human peripheral blood transcriptome

(2014) Rick Jansen et al.   BMC GENOMICS

Genetics of gene expression in immunity to infection

(2014) Benjamin P Fairfax et al.   CURRENT OPINION IN IMMUNOLOGY

Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli

(2014) Darragh Duffy et al.   IMMUNITY

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

(2014) T. Raj et al.   SCIENCE

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

(2014) M. N. Lee et al.   SCIENCE

Innate Immune Activity Conditions the Effect of Regulatory Variants upon Monocyte Gene Expression

(2014) B. P. Fairfax et al.   SCIENCE

Common Risk Alleles for Inflammatory Diseases Are Targets of Recent Positive Selection

(2013) Towfique Raj et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genetic Variants Regulating Immune Cell Levels in Health and Disease

(2013) Valeria Orrù et al.   CELL

Sex- and age-interacting eQTLs in human complex diseases

(2013) Chen Yao et al.   HUMAN MOLECULAR GENETICS

A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci

(2013) David A Hinds et al.   NATURE GENETICS

Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination

(2013) D. Furman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-biased genetic effects on gene regulation in humans

(2012) A. S. Dimas et al.   GENOME RESEARCH

Linking disease associations with regulatory information in the human genome

(2012) M. A. Schaub et al.   GENOME RESEARCH

Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection

(2012) L. B. Barreiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin Its Complex Regulation

(2012) Silvia Naitza et al.   PLoS Genetics

Complement Receptor 1 Gene Variants Are Associated with Erythrocyte Sedimentation Rate

(2011) Iftikhar J. Kullo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ProbABEL package for genome-wide association analysis of imputed data

(2010) Yurii S Aulchenko et al.   BMC BIOINFORMATICS

Genome-wide gene expression regulation as a function of genotype and age in C. elegans

(2010) A. Vinuela et al.   GENOME RESEARCH

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies

(2009) Bryan N. Howie et al.   PLoS Genetics