Genetic associations in type I interferon related pathways with autoimmunity

New roles for the major human 3′-5′ exonuclease TREX1 in human disease

(2010) David Kavanagh et al.   CELL CYCLE

Promoter Insertion/Deletion in the IRF5 Gene Is Highly Associated with Susceptibility to Systemic Lupus Erythematosus in Distinct Populations, But Exerts a Modest Effect on Gene Expression in Peripheral Blood Mononuclear Cells

(2010) S. E. LOFGREN et al.   JOURNAL OF RHEUMATOLOGY

Association ofSTAT4andBLK, but notBANK1orIRF5, with primary antiphospholipid syndrome

(2009) Hong Yin et al.   ARTHRITIS AND RHEUMATISM

The CGGGG insertion/deletion polymorphism of theIRF5promoter is a strong risk factor for primary Sjögren's syndrome

(2009) Corinne Miceli-Richard et al.   ARTHRITIS AND RHEUMATISM

Study of functional variants of theBANK1gene in rheumatoid arthritis

(2009) Gisela Orozco et al.   ARTHRITIS AND RHEUMATISM

Replication of the association between theC8orf13-BLKregion and systemic lupus erythematosus in a Japanese population

(2009) Ikue Ito et al.   ARTHRITIS AND RHEUMATISM

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups

(2009) Bahram Namjou et al.   ARTHRITIS AND RHEUMATISM

Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor

(2009) Maria Ban et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese

(2009) W Yang et al.   GENES AND IMMUNITY

Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese

(2009) Y K Chang et al.   GENES AND IMMUNITY

Genetic associations of LYN with systemic lupus erythematosus

(2009) R Lu et al.   GENES AND IMMUNITY

Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population

(2009) L Guo et al.   GENES AND IMMUNITY

Age- and gender-specific modulation of serum osteopontin and interferon-α by osteopontin genotype in systemic lupus erythematosus

(2009) S N Kariuki et al.   GENES AND IMMUNITY

STAT4 gene polymorphism is associated with psoriasis in the genetically homogeneous population of Crete, Greece

(2009) Maria I. Zervou et al.   HUMAN IMMUNOLOGY

Identification of Loss of Function Mutations in Human Genes Encoding RIG-I and MDA5

(2009) Taeko Shigemoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Association Between Toll-like Receptor 4 Gene Polymorphism and Biopsy-proven Giant Cell Arteritis

(2009) R. PALOMINO-MORALES et al.   JOURNAL OF RHEUMATOLOGY

Evidence for Genetic Association and Interaction Between the TYK2 and IRF5 Genes in Systemic Lupus Erythematosus

(2009) A. HELLQUIST et al.   JOURNAL OF RHEUMATOLOGY

No evidence for genetic association of interferon regulatory factor 3 in systemic lupus erythematosus

(2009) E Sánchez et al.   LUPUS

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

(2009) Peter K Gregersen et al.   NATURE GENETICS

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus

(2009) C. O. Jacob et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Rare Variants of IFIH1, a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

(2009) S. Nejentsev et al.   SCIENCE

STAT4 associates with systemic lupus erythematosus through two independent effects that correlate with gene expression and act additively with IRF5 to increase risk

(2008) A-K Abelson et al.   ANNALS OF THE RHEUMATIC DISEASES

Association ofSTAT4with susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Japanese population

(2008) Shu Kobayashi et al.   ARTHRITIS AND RHEUMATISM

Association ofSTAT4with rheumatoid arthritis: A replication study in three European populations

(2008) Gisela Orozco et al.   ARTHRITIS AND RHEUMATISM

Association of the IRF5 risk haplotype with high serum interferon-α activity in systemic lupus erythematosus patients

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

Identification and functional analysis of CBLB mutations in type 1 diabetes

(2008) Norihide Yokoi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IFIH1-GCA-KCNH7 locus: influence on multiple sclerosis risk

(2008) Alfonso Martínez et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

STAT4 but not TRAF1/C5 variants influence the risk of developing rheumatoid arthritis and systemic lupus erythematosus in Colombians

(2008) R J Palomino-Morales et al.   GENES AND IMMUNITY

Variant form of STAT4 is associated with primary Sjögren's syndrome

(2008) B D Korman et al.   GENES AND IMMUNITY

A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5

(2008) S. Sigurdsson et al.   HUMAN MOLECULAR GENETICS

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

(2008) John Castiblanco et al.   INFECTION GENETICS AND EVOLUTION

A novel mutation in the DNASE1 gene is related with protein instability and decreased enzyme activity in thyroid autoimmunity

(2008) Manuela Dittmar et al.   JOURNAL OF AUTOIMMUNITY

Multiple Sclerosis and Hepatitis C Virus Infection Are Associated with Single Nucleotide Polymorphisms in Interferon Pathway Genes

(2008) Giuliana Fortunato et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Promoter polymorphisms in the IRF3 gene confer protection against systemic lupus erythematosus

(2008) M Akahoshi et al.   LUPUS

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE

The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response

(2008) Daniel A. Muruve et al.   NATURE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osteopontin and Systemic Lupus Erythematosus Association: A Probable Gene-Gender Interaction

(2008) Shizhong Han et al.   PLoS One

Genetic association of interferon-alpha subtypes 1, 2 and 5 in systemic lupus erythematosus

(2008) N. Hirankarn et al.   TISSUE ANTIGENS

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region

(2008) Aya Kawasaki et al.   ARTHRITIS RESEARCH & THERAPY

Specificity of the STAT4 Genetic Association for Severe Disease Manifestations of Systemic Lupus Erythematosus

(2008) Kimberly E. Taylor et al.   PLoS Genetics

Association of the IFIH1-GCA-KCNH7 chromosomal region with rheumatoid arthritis

(2007) A Martinez et al.   ANNALS OF THE RHEUMATIC DISEASES