Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Targeting the CCL2/CCR2 Axis in Cancer Immunotherapy: One Stone, Three Birds?
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 12, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-11-03
DOI
10.3389/fimmu.2021.771210
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State?
- (2021) Sebastian Dommel et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- An Antibody-Drug Conjugate That Selectively Targets Human Monocyte Progenitors for Anti-Cancer Therapy
- (2021) Yuta Izumi et al. Frontiers in Immunology
- Chemokines and the immune response to cancer
- (2021) Aleksandra J. Ozga et al. IMMUNITY
- C-C motif chemokine ligand 2/C-C receptor 2 is associated with glioma recurrence and poor survival
- (2021) Qiuan Yang et al. Experimental and Therapeutic Medicine
- Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progression
- (2021) Wei Bin Fang et al. Scientific Reports
- A Small Molecule CCR2 Antagonist Depletes Tumor Macrophages and Synergizes with Anti–PD-1 in a Murine Model of Cutaneous T-Cell Lymphoma (CTCL)
- (2020) Xuesong Wu et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- CCL2-CCR2 axis recruits tumor associated macrophages to induce immune evasion through PD-1 signaling in esophageal carcinogenesis
- (2020) Hui Yang et al. Molecular Cancer
- Sex-specific adipose tissue imprinting of regulatory T cells
- (2020) Ajithkumar Vasanthakumar et al. NATURE
- Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
- (2020) Samarth Hegde et al. CANCER CELL
- CCL2/CCR2 signaling in cancer pathogenesis
- (2020) Qiongyu Hao et al. Cell Communication and Signaling
- Cancer cell CCR2 orchestrates suppression of the adaptive immune response
- (2020) Miriam R. Fein et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Monocyte Chemoattractant Protein-1 promotes cancer cell migration via c-Raf/MAPK/AP-1 pathway and MMP-9 production in osteosarcoma
- (2020) Ju-Fang Liu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Inhibition of the CCL2 receptor, CCR2, enhances tumor response to immune checkpoint therapy
- (2020) Megan M. Tu et al. Communications Biology
- CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance
- (2019) Michele Mondini et al. Cancer Immunology Research
- HMGB1 decreases CCR-2 expression and migration of M2 macrophages under hypoxia
- (2019) Paulina Araya et al. INFLAMMATION RESEARCH
- Computational design of novel tetra-specific antibody (PD-1/CD47/VEGF/TGF-ß) with IgG-like architecture against non-small cell lung cancer (NSCLC).
- (2019) Lei Zhao et al. JOURNAL OF CLINICAL ONCOLOGY
- Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications
- (2019) Yuxin Lin et al. Journal of Hematology & Oncology
- Ontogeny of Tumor-Associated Macrophages
- (2019) Marie Laviron et al. Frontiers in Immunology
- A positive feedback loop of β-catenin/CCR2 axis promotes regorafenib resistance in colorectal cancer
- (2019) Baochi Ou et al. Cell Death & Disease
- CCR2 inhibition reduces tumor myeloid cells and unmasks a checkpoint inhibitor effect to slow progression of resistant murine gliomas
- (2019) Joseph A. Flores-Toro et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- More Than Just Attractive: How CCL2 Influences Myeloid Cell Behavior Beyond Chemotaxis
- (2019) Martha Gschwandtner et al. Frontiers in Immunology
- Plasticity of myeloid-derived suppressor cells in cancer
- (2018) Evgenii Tcyganov et al. CURRENT OPINION IN IMMUNOLOGY
- CCL2-SQSTM1 positive feedback loop suppresses autophagy to promote chemoresistance in gastric cancer
- (2018) Wenxia Xu et al. International Journal of Biological Sciences
- Characterization of human gastric adenocarcinoma cell lines established from peritoneal ascites
- (2018) Bożenna Mytar et al. Oncology Letters
- Estrogen promotes progression of hormone-dependent breast cancer through CCL2-CCR2 axis by upregulation of Twist via PI3K/AKT/NF-κB signaling
- (2018) Rui Han et al. Scientific Reports
- Crucial biological functions of CCL7 in cancer
- (2018) Yangyang Liu et al. PeerJ
- Abstract 3760: Preclinical antitumor activity of a CC chemokine receptor (CCR) 2/5 dual antagonist as monotherapy and in combination with immune checkpoint blockade
- (2018) Qihong Zhao et al. CANCER RESEARCH
- C‑C chemokine receptor type�2 promotes epithelial‑to‑mesenchymal transition by upregulating matrix metalloproteinase‑2 in human liver cancer
- (2018) Huijin Li et al. ONCOLOGY REPORTS
- CCR2 enhances CD25 expression by FoxP3+ regulatory T cells and regulates their abundance independently of chemotaxis and CCR2+ myeloid cells
- (2018) Yifan Zhan et al. Cellular & Molecular Immunology
- CCR2 Chemokine Receptors Enhance Growth and Cell-Cycle Progression of Breast Cancer Cells Through SRC and PKC Activation
- (2018) Min Yao et al. MOLECULAR CANCER RESEARCH
- Targeting VEGFR2 with Ramucirumab strongly impacts effector/ activated regulatory T cells and CD8+ T cells in the tumor microenvironment
- (2018) Yasuko Tada et al. Journal for ImmunoTherapy of Cancer
- CD40 signaling instructs chronic lymphocytic leukemia cells to attract monocytes via the CCR2 axis
- (2017) Martijn H.A. van Attekum et al. HAEMATOLOGICA
- Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression
- (2017) Yu Zhu et al. IMMUNITY
- The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules
- (2017) Emma M Carrington et al. IMMUNOLOGY AND CELL BIOLOGY
- Transcription factor NFAT5 promotes macrophage survival in rheumatoid arthritis
- (2017) Susanna Choi et al. JOURNAL OF CLINICAL INVESTIGATION
- The fate and lifespan of human monocyte subsets in steady state and systemic inflammation
- (2017) Amit A. Patel et al. JOURNAL OF EXPERIMENTAL MEDICINE
- CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells
- (2017) Eszter Bakos et al. JOURNAL OF IMMUNOLOGY
- Local Immunotherapy of Cancer: Innovative Approaches to Harnessing Tumor-Specific Immune Responses
- (2017) Vivek Murthy et al. JNCI-Journal of the National Cancer Institute
- Neuropathic pain inhibitor, RAP-103, is a potent inhibitor of microglial CCL1/CCR8
- (2017) Mami Noda et al. NEUROCHEMISTRY INTERNATIONAL
- IL-17-producing γδ T cells switch migratory patterns between resting and activated states
- (2017) Duncan R. McKenzie et al. Nature Communications
- Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells
- (2017) Jun An et al. Oncotarget
- CD40 signaling instructs chronic lymphocytic leukemia cells to attract monocytes via the CCR2 axis
- (2017) Martijn H.A. van Attekum et al. HAEMATOLOGICA
- Local Immunotherapy of Cancer: Innovative Approaches to Harnessing Tumor-Specific Immune Responses
- (2017) Vivek Murthy et al. JNCI-Journal of the National Cancer Institute
- Impact of Depleting Therapeutic Monoclonal Antibodies on the Host Adaptive Immunity: A Bonus or a Malus?
- (2017) Claire Deligne et al. Frontiers in Immunology
- The CCL2/CCR2 Axis Affects Transmigration and Proliferation but Not Resistance to Chemotherapy of Acute Myeloid Leukemia Cells
- (2017) Patricia Macanas-Pirard et al. PLoS One
- A 48-week randomized phase 2b study evaluating cenicriviroc versus efavirenz in treatment-naive HIV-infected adults with C-C chemokine receptor type 5-tropic virus
- (2016) Melanie Thompson et al. AIDS
- CCR2 Influences T Regulatory Cell Migration to Tumors and Serves as a Biomarker of Cyclophosphamide Sensitivity
- (2016) Pierre-Louis Loyher et al. CANCER RESEARCH
- FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling
- (2016) Xuguang Yang et al. CANCER RESEARCH
- MCP-1-induced ERK/GSK-3β/Snail signaling facilitates the epithelial–mesenchymal transition and promotes the migration of MCF-7 human breast carcinoma cells
- (2016) Shun Li et al. Cellular & Molecular Immunology
- The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells
- (2016) Shinelle Menezes et al. IMMUNITY
- Targeting tumour-associated macrophages with CCR2 inhibition in combination with FOLFIRINOX in patients with borderline resectable and locally advanced pancreatic cancer: a single-centre, open-label, dose-finding, non-randomised, phase 1b trial
- (2016) Timothy M Nywening et al. LANCET ONCOLOGY
- Microbiota induces tonic CCL2 systemic levels that control pDC trafficking in steady state
- (2016) M Swiecki et al. Mucosal Immunology
- Autocrine MCP-1/CCR2 signaling stimulates proliferation and migration of renal carcinoma cells
- (2016) Christoph Küper et al. Oncology Letters
- Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
- (2016) Vincenzo Bronte et al. Nature Communications
- Blockade of MCP-1/CCR4 signaling-induced recruitment of activated regulatory cells evokes an antitumor immune response in head and neck squamous cell carcinoma
- (2016) Wei Sun et al. Oncotarget
- High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection
- (2016) Ruochen Li et al. Oncotarget
- CCL2/CCR2 axis is associated with postoperative survival and recurrence of patients with non-metastatic clear-cell renal cell carcinoma
- (2016) Zewei Wang et al. Oncotarget
- Increasing the efficacy of radiotherapy by modulating the CCR2/CCR5 chemokine axes
- (2016) Kelli A. Connolly et al. Oncotarget
- Targeting the CCL2-CCR2 signaling axis in cancer metastasis
- (2016) Su Yin Lim et al. Oncotarget
- Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis
- (2016) Mary Speir et al. Nature Microbiology
- CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice
- (2016) Xuguang Chen et al. PLoS One
- Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma
- (2015) Xiaoguang Li et al. GUT
- The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity
- (2015) Andrew L. Croxford et al. IMMUNITY
- CCL2-induced chemokine cascade promotes breast cancer metastasis by enhancing retention of metastasis-associated macrophages
- (2015) Takanori Kitamura et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Periostin secreted by glioblastoma stem cells recruits M2 tumour-associated macrophages and promotes malignant growth
- (2015) Wenchao Zhou et al. NATURE CELL BIOLOGY
- Haptoglobin and CCR2 receptor expression in ovarian cancer cells that were exposed to ascitic fluid: Exploring a new role of haptoglobin in the tumoral microenvironment
- (2015) OL Garibay-Cerdenares et al. Cell Adhesion & Migration
- Overcoming melanoma resistance to vemurafenib by targeting CCL2-induced miR-34a, miR-100 and miR-125b
- (2015) Elisabetta Vergani et al. Oncotarget
- CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function
- (2015) Eunyoung Chun et al. Cell Reports
- The effect of CCR2 inhibitor CCX140-B on residual albuminuria in patients with type 2 diabetes and nephropathy: a randomised trial
- (2015) Dick de Zeeuw et al. Lancet Diabetes & Endocrinology
- Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor
- (2015) Elsenoor J. Klaver et al. PLoS One
- MicroRNA-135b, a HSF1 target, promotes tumor invasion and metastasis by regulating RECK and EVI5 in hepatocellular carcinoma
- (2015) Yan Li et al. Oncotarget
- Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+macrophage infiltration in mice
- (2014) Christer Baeck et al. HEPATOLOGY
- Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
- (2014) Peter J. Murray et al. IMMUNITY
- GM-CSF-Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis
- (2014) H.-J. Ko et al. JOURNAL OF IMMUNOLOGY
- CCL2 Shapes Macrophage Polarization by GM-CSF and M-CSF: Identification of CCL2/CCR2-Dependent Gene Expression Profile
- (2014) E. Sierra-Filardi et al. JOURNAL OF IMMUNOLOGY
- Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes
- (2014) F. H. W. Shand et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The cellular and molecular origin of tumor-associated macrophages
- (2014) R. A. Franklin et al. SCIENCE
- Carlumab, an anti-C-C chemokine ligand 2 monoclonal antibody, in combination with four chemotherapy regimens for the treatment of patients with solid tumors: an open-label, multicenter phase 1b study
- (2014) Irene Brana et al. Targeted Oncology
- Alterations of gene expression and protein synthesis in co-cultured adipose tissue-derived stem cells and squamous cell-carcinoma cells: consequences for clinical applications
- (2014) Eva Koellensperger et al. Stem Cell Research & Therapy
- Depletion of Tumor-Associated Macrophages Slows the Growth of Chemically Induced Mouse Lung Adenocarcinomas
- (2014) Jason M. Fritz et al. Frontiers in Immunology
- CCL2 increases αvβ3 integrin expression and subsequently promotes prostate cancer migration
- (2013) Tien-Huang Lin et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Brain metastasis in renal cancer patients: metastatic pattern, tumour-associated macrophages and chemokine/chemoreceptor expression
- (2013) L Wyler et al. BRITISH JOURNAL OF CANCER
- A first-in-human, first-in-class, phase I study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 in patients with solid tumors
- (2013) Shahneen K. Sandhu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis
- (2013) D. E. Sanford et al. CLINICAL CANCER RESEARCH
- Mesenchymal Contribution to Recruitment, Infiltration, and Positioning of Leukocytes in Human Melanoma Tissues
- (2013) Rafael Samaniego et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Bcl-x Inactivation in Macrophages Accelerates Progression of Advanced Atherosclerotic Lesions in Apoe −/− Mice
- (2012) Andrew I.U. Shearn et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Cancer-associated fibroblasts up-regulate CCL2, CCL26, IL6 and LOXL2 genes related to promotion of cancer progression in hepatocellular carcinoma cells
- (2012) Zu-Yau Lin et al. BIOMEDICINE & PHARMACOTHERAPY
- Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway
- (2012) Monika Julia Wolf et al. CANCER CELL
- Tumor-Derived Granulocyte-Macrophage Colony-Stimulating Factor Regulates Myeloid Inflammation and T Cell Immunity in Pancreatic Cancer
- (2012) Lauren J. Bayne et al. CANCER CELL
- Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance
- (2012) Elizabeth S. Nakasone et al. CANCER CELL
- Expression of monocyte chemoattractant protein-1 and CC chemokine receptor 2 in non-small cell lung cancer and its significance
- (2012) Xiao-wei Zhang et al. CANCER IMMUNOLOGY IMMUNOTHERAPY
- CCL2 Mediates Cross-talk between Cancer Cells and Stromal Fibroblasts That Regulates Breast Cancer Stem Cells
- (2012) A. Tsuyada et al. CANCER RESEARCH
- Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice
- (2012) Y. Nio et al. DIABETOLOGIA
- Chemokine CCL2 enhances survival and invasiveness of endometrial stromal cells in an autocrine manner by activating Akt and MAPK/Erk1/2 signal pathway
- (2012) Ming-Qing Li et al. FERTILITY AND STERILITY
- Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
- (2012) Simon Yona et al. IMMUNITY
- Phase 2 study of carlumab (CNTO 888), a human monoclonal antibody against CC-chemokine ligand 2 (CCL2), in metastatic castration-resistant prostate cancer
- (2012) Kenneth J. Pienta et al. INVESTIGATIONAL NEW DRUGS
- CCL2/CCR2 Chemokine Signaling Coordinates Survival and Motility of Breast Cancer Cells through Smad3 Protein- and p42/44 Mitogen-activated Protein Kinase (MAPK)-dependent Mechanisms
- (2012) Wei Bin Fang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Transgenic CCL2 Expression in the Central Nervous System Results in a Dysregulated Immune Response and Enhanced Lethality after Coronavirus Infection
- (2012) J. A. Trujillo et al. JOURNAL OF VIROLOGY
- Origins of tumor-associated macrophages and neutrophils
- (2012) V. Cortez-Retamozo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- FSP1+ Fibroblasts Promote Skin Carcinogenesis by Maintaining MCP-1-Mediated Macrophage Infiltration and Chronic Inflammation
- (2011) Jinhua Zhang et al. AMERICAN JOURNAL OF PATHOLOGY
- CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras/Raf/MEK/ERK/NF-κB signaling pathway
- (2011) Chih-Hsin Tang et al. BIOCHEMICAL PHARMACOLOGY
- Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist
- (2011) Changsheng Zheng et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma
- (2011) Victoria Sanz-Moreno et al. CANCER CELL
- Suppression of uPA and uPAR blocks radiation-induced MCP-1 mediated recruitment of endothelial cells in meningioma
- (2011) Arun Kumar Nalla et al. CELLULAR SIGNALLING
- IL-8 increases integrin expression and cell motility in human chondrosarcoma cells
- (2011) Chun-Yi Lee et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway
- (2011) Sudhanshu Agrawal et al. JOURNAL OF CLINICAL IMMUNOLOGY
- An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes
- (2011) Sufyan G. Sayyed et al. KIDNEY INTERNATIONAL
- A MCP1 fusokine with CCR2-specific tumoricidal activity
- (2011) Moutih Rafei et al. Molecular Cancer
- CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
- (2011) Bin-Zhi Qian et al. NATURE
- Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist
- (2011) Chu-Biao Xue et al. ACS Medicinal Chemistry Letters
- Different Tumor Microenvironments Contain Functionally Distinct Subsets of Macrophages Derived from Ly6C(high) Monocytes
- (2010) K. Movahedi et al. CANCER RESEARCH
- CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice
- (2010) Yue Si et al. JOURNAL OF CLINICAL INVESTIGATION
- The obesity and inflammatory marker haptoglobin attracts monocytes via interaction with chemokine (C-C motif) receptor 2 (CCR2)
- (2009) Margherita Maffei et al. BMC BIOLOGY
- Involvement of AdipoR receptor in adiponectin-induced motility and α2β1 integrin upregulation in human chondrosarcoma cells
- (2009) Yung-Cheng Chiu et al. CARCINOGENESIS
- Inflammatory Monocytes Facilitate Adaptive CD4 T Cell Responses during Respiratory Fungal Infection
- (2009) Tobias M. Hohl et al. Cell Host & Microbe
- Role of Eotaxin-1 Signaling in Ovarian Cancer
- (2009) V. Levina et al. CLINICAL CANCER RESEARCH
- Tumor Cell-Microenvironment Interaction Models Coupled with Clinical Validation Reveal CCL2 and SNCG as Two Predictors of Colorectal Cancer Hepatic Metastasis
- (2009) H. Hu et al. CLINICAL CANCER RESEARCH
- Recent developments in CCR2 antagonists
- (2009) Mingde Xia et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response
- (2009) Nan Zhang et al. IMMUNITY
- Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells
- (2009) Maylis Dagouassat et al. INTERNATIONAL JOURNAL OF CANCER
- Chemokine (C-C Motif) Ligand 2 Engages CCR2+Stromal Cells of Monocytic Origin to Promote Breast Cancer Metastasis to Lung and Bone
- (2009) Xin Lu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- CCL2 and Interleukin-6 Promote Survival of Human CD11b+Peripheral Blood Mononuclear Cells and Induce M2-type Macrophage Polarization
- (2009) Hernan Roca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Brief Report: Increased Apoptosis in Advanced Atherosclerotic Lesions of Apoe −/− Mice Lacking Macrophage Bcl-2
- (2008) Edward Thorp et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Selective roles for antiapoptotic MCL-1 during granulocyte development and macrophage effector function
- (2008) D. A. Steimer et al. BLOOD
- A complex pattern of chemokine receptor expression is seen in osteosarcoma
- (2008) Irene von Luettichau et al. BMC CANCER
- Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins
- (2008) Ajaikumar B. Kunnumakkara et al. CANCER LETTERS
- Efficient Homing of Multipotent Adult Mesenchymal Stem Cells Depends on FROUNT-Mediated Clustering of CCR2
- (2008) Fikru Belema-Bedada et al. Cell Stem Cell
- Advances in Targeting the Ras/Raf/MEK/Erk Mitogen-Activated Protein Kinase Cascade with MEK Inhibitors for Cancer Therapy
- (2008) B. B. Friday et al. CLINICAL CANCER RESEARCH
- Monocyte chemotactic protein-1 in the migration of differentiated leukaemic cells toward alveolar epithelial cells
- (2008) W-H. Tsai et al. EUROPEAN RESPIRATORY JOURNAL
- CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase/AKT-dependent Survivin Up-regulation
- (2008) Hernan Roca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pharmacological Profile of JNJ-27141491 [(S)-3-[3,4-Difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl Acid Methyl Ester], as a Noncompetitive and Orally Active Antagonist of the Human Chemokine Receptor CCR2
- (2008) M. Buntinx et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Chemokine receptor antagonists: overcoming developmental hurdles
- (2008) Richard Horuk NATURE REVIEWS DRUG DISCOVERY
- Autophagic cell death: the story of a misnomer
- (2008) Guido Kroemer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Breakdown of the Endothelial Barrier Function in Tumor Cell Transmigration
- (2007) Claudia Tanja Mierke et al. BIOPHYSICAL JOURNAL
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started