Diverse Mechanisms of Protective Anti-Pneumococcal Antibodies

Broadly Reactive Human Monoclonal Antibodies Targeting the Pneumococcal Histidine Triad Protein Protect against Fatal Pneumococcal Infection

(2021) Jiachen Huang et al.   INFECTION AND IMMUNITY

A nanogel-based trivalent PspA nasal vaccine protects macaques from intratracheal challenge with pneumococci

(2021) Rika Nakahashi-Ouchida et al.   VACCINE

Neuraminidase B controls neuraminidase A-dependent mucus production and evasion

(2021) Alexandria J. Hammond et al.   PLoS Pathogens

Protective role of PhtD and its amino and carboxyl fragments against pneumococcal sepsis

(2021) Greiciely O. André et al.   VACCINE

Evaluating Functional Immunity Following Encapsulated Bacterial Infection and Vaccination

(2021) Zheng Quan Toh et al.   Vaccines

Isolation and Characterization of Human Monoclonal Antibodies to Pneumococcal Capsular Polysaccharide 3

(2021) Rachelle Babb et al.   Microbiology Spectrum

Evaluation of protective immunity responses against pneumococcal PhtD and its C-terminal in combination with outer-membrane vesicles as adjuvants

(2020) Mohammadali Malekan et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Immunization with Recombinant Pneumolysin Induces the Production of Antibodies and Protects Mice in a Model of Systemic Infection Caused by Streptococcus pneumoniae

(2020) E. S. Petukhova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Immunization with PhtD truncated fragments reduces nasopharyngeal colonization by Streptococcus pneumoniae

(2020) Greiciely O. André et al.   VACCINE

A New Pneumococcal Capsule Type, 10D, is the 100th Serotype and Has a Large cps Fragment from an Oral Streptococcus

(2020) Feroze Ganaie et al.   mBio

Preclinical Efficacy of a Trivalent Human FcγRI-Targeted Adjuvant-Free Subunit Mucosal Vaccine against Pulmonary Pneumococcal Infection

(2020) Sudeep Kumar et al.   Vaccines

Preclinical in vitro and in vivo profile of a highly-attenuated, broadly efficacious pneumolysin genetic toxoid

(2020) Ann Thanawastien et al.   VACCINE

Isotype-specific outcomes in Fc gamma receptor targeting of PspA using fusion proteins as a vaccination strategy against Streptococcus pneumoniae infection

(2020) Kari Wiedinger et al.   VACCINE

Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional Activity

(2020) Indre Kucinskaite-Kodze et al.   Biomolecules

Sugar-Coated Killer: Serotype 3 Pneumococcal Disease

(2020) Jennifer N. Luck et al.   Frontiers in Cellular and Infection Microbiology

Pneumolysin induces platelet destruction, not platelet activation, which can be prevented by immunoglobulin preparations in vitro

(2020) Kristin Jahn et al.   Blood Advances

Genetic diversity and antigenicity analysis of Streptococcus pneumoniae pneumolysin isolated from children with pneumococcal infection

(2019) Chenxi Han et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

PspA facilitates evasion of pneumococci from bactericidal activity of neutrophil extracellular traps (NETs)

(2019) Perla J. Martinez et al.   MICROBIAL PATHOGENESIS

Efficacy, safety and immunogenicity of a pneumococcal protein-based vaccine co-administered with 13-valent pneumococcal conjugate vaccine against acute otitis media in young children: A phase IIb randomized study

(2019) Laura L. Hammitt et al.   VACCINE

The Modified Surface Killing Assay Distinguishes between Protective and Nonprotective Antibodies to PspA

(2019) Kristopher R. Genschmer et al.   mSphere

A Capsular Polysaccharide-Specific Antibody Alters Streptococcus pneumoniae Gene Expression during Nasopharyngeal Colonization of Mice

(2018) Christopher R. Doyle et al.   INFECTION AND IMMUNITY

Streptococcus pneumoniae: transmission, colonization and invasion

(2018) Jeffrey N. Weiser et al.   NATURE REVIEWS MICROBIOLOGY

Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity

(2018) M. Georgieva et al.   mBio

Current status and future directions of invasive pneumococcal diseases and prophylactic approaches to control them

(2018) Paeton L. Wantuch et al.   Human Vaccines & Immunotherapeutics

Role of phosphorylcholine in Streptococcus pneumoniae and nontypeable Haemophilus influenzae adherence to epithelial cells

(2018) Hiroyuki Iuchi et al.   AURIS NASUS LARYNX

The Pneumococcal Surface Proteins PspA and PspC Sequester Host C4-Binding Protein To Inactivate Complement C4b on the Bacterial Surface

(2018) Kashif S. Haleem et al.   INFECTION AND IMMUNITY

Assessing the function of pneumococcal neuraminidases NanA, NanB and NanC in in vitro and in vivo lung infection models using monoclonal antibodies

(2018) Philipp Janesch et al.   Virulence

Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival

(2018) Karthik Subramanian et al.   Nature Microbiology

Transcutaneous immunization with pneumococcal surface protein A in mice

(2017) Hiromi Nagano et al.   LARYNGOSCOPE

Trivalent pneumococcal protein vaccine protects against experimental acute otitis media caused by Streptococcus pneumoniae in an infant murine model

(2017) Qingfu Xu et al.   VACCINE

Efficacy of a novel, protein-based pneumococcal vaccine against nasopharyngeal carriage of Streptococcus pneumoniae in infants: A phase 2, randomized, controlled, observer-blind study

(2017) Aderonke Odutola et al.   VACCINE

Antibodies to PcpA and PhtD protect mice against Streptococcus pneumoniae by a macrophage- and complement-dependent mechanism

(2017) Lucian Visan et al.   Human Vaccines & Immunotherapeutics

Naturally Acquired Human Immunity to Pneumococcus Is Dependent on Antibody to Protein Antigens

(2017) Robert Wilson et al.   PLoS Pathogens

Towards Identifying Protective B-Cell Epitopes: The PspA Story

(2017) Naeem Khan et al.   Frontiers in Microbiology

Prevalence and antibiotic resistance of commensalStreptococcus pneumoniaein nine European countries

(2016) Rachid Y Yahiaoui et al.   Future Microbiology

The effects of differences in pspA alleles and capsular types on the resistance of Streptococcus pneumoniae to killing by apolactoferrin

(2016) Shaper Mirza et al.   MICROBIAL PATHOGENESIS

Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage

(2016) E Mitsi et al.   Mucosal Immunology

Reduction of Streptococcus pneumoniae Colonization and Dissemination by a Nonopsonic Capsular Polysaccharide Antibody

(2016) Christopher R. Doyle et al.   mBio

Nonencapsulated Streptococcus pneumoniae : Emergence and Pathogenesis

(2016) Lance E. Keller et al.   mBio

A bivalent pneumococcal histidine triad protein D-choline-binding protein A vaccine elicits functional antibodies that passively protect mice from Streptococcus pneumoniae challenge

(2016) Martina M. Ochs et al.   Human Vaccines & Immunotherapeutics

Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen

(2016) Philippe Hermand et al.   Human Vaccines & Immunotherapeutics

Generation and Improvement of Effector Function of a Novel Broadly Reactive and Protective Monoclonal Antibody against Pneumococcal Surface Protein A of Streptococcus pneumoniae

(2016) Sascha A. Kristian et al.   PLoS One

Multivalent Pneumococcal Protein Vaccines Comprising Pneumolysoid with Epitopes/Fragments of CbpA and/or PspA Elicit Strong and Broad Protection

(2015) Austen Chen et al.   Clinical and Vaccine Immunology

The First Histidine Triad Motif of PhtD Is Critical for Zinc Homeostasis inStreptococcus pneumoniae

(2015) Bart A. Eijkelkamp et al.   INFECTION AND IMMUNITY

Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage

(2015) S Glennie et al.   Mucosal Immunology

Diversity of Pneumolysin and Pneumococcal Histidine Triad Protein D of Streptococcus pneumoniae Isolated from Invasive Diseases in Korean Children

(2015) Ki Wook Yun et al.   PLoS One

Safety and immunogenicity of a trivalent recombinant PcpA, PhtD, and PlyD1 pneumococcal protein vaccine in adults, toddlers, and infants: A phase I randomized controlled study

(2015) W. Abdullah Brooks et al.   VACCINE

Passive protection of mice againstStreptococcus pneumoniaechallenge by naturally occurring and vaccine-induced human anti-PhtD antibodies

(2015) Roger H Brookes et al.   Human Vaccines & Immunotherapeutics

Rationale and prospects for novel pneumococcal vaccines

(2015) Kristin Moffitt et al.   Human Vaccines & Immunotherapeutics

Correlation betweenIn VitroComplement Deposition and Passive Mouse Protection of Anti-Pneumococcal Surface Protein A Monoclonal Antibodies

(2014) Naeem Khan et al.   Clinical and Vaccine Immunology

Detoxified pneumolysin derivative plym2 directly protects against pneumococcal infection via induction of inflammatory cytokines

(2014) Jingcai Lu et al.   IMMUNOLOGICAL INVESTIGATIONS

Role of Pht Proteins in Attachment of Streptococcus pneumoniae to Respiratory Epithelial Cells

(2014) Anna Kallio et al.   INFECTION AND IMMUNITY

Human Antibodies to PhtD, PcpA, and Ply Reduce Adherence to Human Lung Epithelial Cells and Murine Nasopharyngeal Colonization by Streptococcus pneumoniae

(2014) Ravinder Kaur et al.   INFECTION AND IMMUNITY

Species-Specific Interaction of Streptococcus pneumoniae with Human Complement Factor H

(2014) L. Lu et al.   JOURNAL OF IMMUNOLOGY

Effects of Vaccination on Invasive Pneumococcal Disease in South Africa

(2014) Anne von Gottberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3

(2014) S. Kohler et al.   THROMBOSIS AND HAEMOSTASIS

Protective properties of a fusion pneumococcal surface protein A (PspA) vaccine against pneumococcal challenge by five different PspA clades in mice

(2014) Zhenyu Piao et al.   VACCINE

Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults: A phase I/II randomized clinical study

(2014) Geert Leroux-Roels et al.   VACCINE

Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model

(2014) David Verhoeven et al.   VACCINE

Safety, Immunogenicity, and Antibody Persistence following an Investigational Streptococcus pneumoniae and Haemophilus influenzae Triple-Protein Vaccine in a Phase 1 Randomized Controlled Study in Healthy Adults

(2013) Johan Berglund et al.   Clinical and Vaccine Immunology

Comparative Immunogenicity and Efficacy of 13-Valent and 7-Valent Pneumococcal Conjugate Vaccines in Reducing Nasopharyngeal Colonization: A Randomized Double-Blind Trial

(2013) Ron Dagan et al.   CLINICAL INFECTIOUS DISEASES

Serum antibody responses to pneumococcal colonization in the first 2 years of life: results from an SE Asian longitudinal cohort study

(2013) P. Turner et al.   CLINICAL MICROBIOLOGY AND INFECTION

Biofilm Formation Enhances Fomite Survival of Streptococcus pneumoniae and Streptococcus pyogenes

(2013) Laura R. Marks et al.   INFECTION AND IMMUNITY

Surface Association of Pht Proteins of Streptococcus pneumoniae

(2013) Charles D. Plumptre et al.   INFECTION AND IMMUNITY

Surface Charge of Streptococcus pneumoniae Predicts Serotype Distribution

(2013) Yuan Li et al.   INFECTION AND IMMUNITY

The Choline-binding Protein PspC ofStreptococcus pneumoniaeInteracts with the C-terminal Heparin-binding Domain of Vitronectin

(2013) Sylvia Voss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pneumococcal vaccine and opsonic pneumococcal antibody

(2013) Joon Young Song et al.   JOURNAL OF INFECTION AND CHEMOTHERAPY

Broadly Protective Protein-Based Pneumococcal Vaccine Composed of Pneumolysin Toxoid–CbpA Peptide Recombinant Fusion Protein

(2013) Beth Mann et al.   JOURNAL OF INFECTIOUS DISEASES

Characterization of Protective Immune Responses Induced by Pneumococcal Surface Protein A in Fusion with Pneumolysin Derivatives

(2013) Cibelly Goulart et al.   PLoS One

Vaccination against Streptococcus pneumoniae Using Truncated Derivatives of Polyhistidine Triad Protein D

(2013) Charles D. Plumptre et al.   PLoS One

A Phase I, dose-escalation trial in adults of three recombinant attenuated Salmonella Typhi vaccine vectors producing Streptococcus pneumoniae surface protein antigen PspA

(2013) Sharon E. Frey et al.   VACCINE

Novel Role for the Streptococcus pneumoniae Toxin Pneumolysin in the Assembly of Biofilms

(2013) J. R. Shak et al.   mBio

The Absence of PspA or Presence of Antibody to PspA Facilitates the Complement-Dependent Phagocytosis of PneumococciIn Vitro

(2012) Bing Ren et al.   Clinical and Vaccine Immunology

Issues and challenges in the development of pneumococcal protein vaccines

(2012) Amy Sarah Ginsburg et al.   Expert Review of Vaccines

The fundamental link between pneumococcal carriage and disease

(2012) Birgit Simell et al.   Expert Review of Vaccines

Nasopharyngeal Colonization Elicits Antibody Responses to Staphylococcal and Pneumococcal Proteins That Are Not Associated with a Reduced Risk of Subsequent Carriage

(2012) Sabine M. P. J. Prevaes et al.   INFECTION AND IMMUNITY

A Serotype 3 Pneumococcal Capsular Polysaccharide-Specific Monoclonal Antibody Requires Fcγ Receptor III and Macrophages To Mediate Protection against Pneumococcal Pneumonia in Mice

(2012) Sarah Weber et al.   INFECTION AND IMMUNITY

Pneumococcal Surface Protein A Inhibits Complement Deposition on the Pneumococcal Surface by Competing with the Binding of C-Reactive Protein to Cell-Surface Phosphocholine

(2012) R. Mukerji et al.   JOURNAL OF IMMUNOLOGY

PcpA of Streptococcus pneumoniae mediates adherence to nasopharyngeal and lung epithelial cells and elicits functional antibodies in humans

(2012) M. Nadeem Khan et al.   MICROBES AND INFECTION

Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans

(2012) M. Nadeem Khan et al.   VACCINE

Safety and immunogenicity of a pneumococcal histidine triad protein D vaccine candidate in adults

(2012) Michael Seiberling et al.   VACCINE

Safety and immunogenicity of pneumococcal protein vaccine candidates: Monovalent choline-binding protein A (PcpA) vaccine and bivalent PcpA–pneumococcal histidine triad protein D vaccine

(2012) Monica Bologa et al.   VACCINE

Safety and immunogenicity of the pneumococcal pneumolysin derivative PlyD1 in a single-antigen protein vaccine candidate in adults

(2012) Thierry Kamtchoua et al.   VACCINE

Nasal immunization of mice withLactobacillus caseiexpressing the pneumococcal surface protein C primes the immune system and decreases pneumococcal nasopharyngeal colonization in mice

(2011) Marília de Lúcia Hernani et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Mucosal Immunization with an Unadjuvanted Vaccine That Targets Streptococcus pneumoniae PspA to Human Fcγ Receptor Type I Protects against Pneumococcal Infection through Complement- and Lactoferrin-Mediated Bactericidal Activity

(2011) Constantine Bitsaktsis et al.   INFECTION AND IMMUNITY

ThreeStreptococcus pneumoniaeSialidases: Three Different Products

(2011) Guogang Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Combined protective effects of anti-PhtD and anti-pneumococcal polysaccharides

(2011) Philippe Denoël et al.   VACCINE

The factor H-binding fragment of PspC as a vaccine antigen for the induction of protective humoral immunity against experimental pneumococcal sepsis

(2011) Susanna Ricci et al.   VACCINE

A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae

(2011) Philippe Denoël et al.   VACCINE

Impact of the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) on bacterial nasopharyngeal carriage

(2011) Roman Prymula et al.   VACCINE

Antibodies to Streptococcus pneumoniae Capsular Polysaccharide Enhance Pneumococcal Quorum Sensing

(2011) M. Yano et al.   mBio

Role of pneumococcal pneumolysin in the induction of an inflammatory response in human epithelial cells

(2010) In-Hwa Yoo et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Three Surface Exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, Promote Resistance to Opsonophagocytic Killing by Human Neutrophils

(2010) A. B. Dalia et al.   INFECTION AND IMMUNITY

Immune Responses to Recombinant Pneumococcal PsaA Antigen Delivered by a Live Attenuated Salmonella Vaccine

(2010) S. Wang et al.   INFECTION AND IMMUNITY

Preclinical Evaluation of the Pht Proteins as Potential Cross-Protective Pneumococcal Vaccine Antigens

(2010) Fabrice Godfroid et al.   INFECTION AND IMMUNITY

The Proline-Rich Region of Pneumococcal Surface Proteins A and C Contains Surface-Accessible Epitopes Common to All Pneumococci and Elicits Antibody-Mediated Protection against Sepsis

(2010) C. C. Daniels et al.   INFECTION AND IMMUNITY

Immunization with Pneumolysin Protects Against Both Retinal and Global Damage Caused by Streptococcus pneumoniae Endophthalmitis

(2010) Melissa E. Sanders et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Immunogenicity of a Reduced Schedule of Pneumococcal Conjugate Vaccine in Healthy Infants and Correlates of Protection for Serotype 6B in the United Kingdom

(2010) David Goldblatt et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Maternal Antibodies to Pneumolysin but Not to Pneumococcal Surface Protein A Delay Early Pneumococcal Carriage in High-Risk Papua New Guinean Infants

(2009) J. P. Francis et al.   Clinical and Vaccine Immunology

Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice

(2009) D. M. Ferreira et al.   Clinical and Vaccine Immunology

Efficacy of Opsonic and Nonopsonic Serotype 3 Pneumococcal Capsular Polysaccharide-Specific Monoclonal Antibodies against Intranasal Challenge with Streptococcus pneumoniae in Mice

(2009) H. Tian et al.   INFECTION AND IMMUNITY

The Streptococcus pneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms

(2009) C. Hyams et al.   INFECTION AND IMMUNITY

The NanA Neuraminidase of Streptococcus pneumoniae Is Involved in Biofilm Formation

(2009) D. Parker et al.   INFECTION AND IMMUNITY

Pneumolysin Localizes to the Cell Wall of Streptococcus pneumoniae

(2009) K. E. Price et al.   JOURNAL OF BACTERIOLOGY

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

(2009) Carlos J. Orihuela et al.   JOURNAL OF CLINICAL INVESTIGATION

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

(2009) Satoshi Uchiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical Isolates of Streptococcus pneumoniae Bind the Complement Inhibitor C4b-Binding Protein in a PspC Allele-Dependent Fashion

(2009) A. Dieudonne-Vatran et al.   JOURNAL OF IMMUNOLOGY

Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates

(2009) Katherine L O'Brien et al.   LANCET

Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H

(2008) Abiodun D. Ogunniyi et al.   FASEB JOURNAL

Streptococcus pneumoniae Surface Protein PcpA Elicits Protection against Lung Infection and Fatal Sepsis

(2008) D. T. Glover et al.   INFECTION AND IMMUNITY

Epidemiologic Evidence for Serotype‐Specific Acquired Immunity to Pneumococcal Carriage

(2008) Daniel M. Weinberger et al.   JOURNAL OF INFECTIOUS DISEASES