Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen

Reactogenicity, safety and immunogenicity of a protein-based pneumococcal vaccine in Gambian children aged 2–4 years: A phase II randomized study

(2015) A Odutola et al.   Human Vaccines & Immunotherapeutics

Density and Duration of Pneumococcal Carriage Is Maintained by Transforming Growth Factor β1 and T Regulatory Cells

(2014) Daniel R. Neill et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Review: Current and new generation pneumococcal vaccines

(2014) Charles Feldman et al.   JOURNAL OF INFECTION

Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults: A phase I/II randomized clinical study

(2014) Geert Leroux-Roels et al.   VACCINE

Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: A phase II randomized clinical trial

(2014) Roman Prymula et al.   VACCINE

Novel Role for the Streptococcus pneumoniae Toxin Pneumolysin in the Assembly of Biofilms

(2013) J. R. Shak et al.   mBio

Characterization of pneumolysin from Streptococcus pneumoniae, interacting with carbohydrate moiety and cholesterol as a component of cell membrane

(2012) Jong Eun Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neutralizing Antibodies Elicited by a Novel Detoxified Pneumolysin Derivative, PlyD1, Provide Protection against Both Pneumococcal Infection and Lung Injury

(2012) Danielle Salha et al.   INFECTION AND IMMUNITY

Effectiveness of the ten-valent pneumococcal Haemophilus influenzae protein D conjugate vaccine (PHiD-CV10) against invasive pneumococcal disease: a cluster randomised trial

(2012) Arto A Palmu et al.   LANCET

Safety and immunogenicity of the pneumococcal pneumolysin derivative PlyD1 in a single-antigen protein vaccine candidate in adults

(2012) Thierry Kamtchoua et al.   VACCINE

Factors affecting the development of systemic inflammatory response syndrome in pneumococcal infections

(2011) Esther Calbo et al.   CURRENT OPINION IN INFECTIOUS DISEASES

13-valent pneumococcal conjugate vaccine (PCV13)

(2011) Johanna MC Jefferies et al.   Human vaccines & immunotherapeutics

Structure-guided Antigen Engineering Yields Pneumolysin Mutants Suitable for Vaccination against Pneumococcal Disease

(2011) Eliud O. Oloo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae

(2011) Philippe Denoël et al.   VACCINE

Identification of novel pneumolysin alleles from paediatric carriage isolates of Streptococcus pneumoniae

(2010) J. M. C. Jefferies et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Antibody and cell-mediated immunity to Streptococcus pneumoniae: implications for vaccine development

(2010) Richard Malley   JOURNAL OF MOLECULAR MEDICINE-JMM

Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae

(2010) S. Rioux et al.   MICROBIOLOGY-SGM

Maternal Antibodies to Pneumolysin but Not to Pneumococcal Surface Protein A Delay Early Pneumococcal Carriage in High-Risk Papua New Guinean Infants

(2009) J. P. Francis et al.   Clinical and Vaccine Immunology

Emergence of a serotype 1 Streptococcus pneumoniae lineage colonising healthy children in Portugal in the seven-valent conjugate vaccination era

(2007) S. Nunes et al.   CLINICAL MICROBIOLOGY AND INFECTION