Human Antibodies to PhtD, PcpA, and Ply Reduce Adherence to Human Lung Epithelial Cells and Murine Nasopharyngeal Colonization by Streptococcus pneumoniae

Density and Duration of Pneumococcal Carriage Is Maintained by Transforming Growth Factor β1 and T Regulatory Cells

(2014) Daniel R. Neill et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Randomized Controlled Study of the Safety and Immunogenicity of Pneumococcal Vaccine Formulations Containing PhtD and Detoxified Pneumolysin with Alum or Adjuvant System AS02Vin Elderly Adults

(2014) Karlis Pauksens et al.   Clinical and Vaccine Immunology

Role of Pht Proteins in Attachment of Streptococcus pneumoniae to Respiratory Epithelial Cells

(2014) Anna Kallio et al.   INFECTION AND IMMUNITY

Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model

(2014) David Verhoeven et al.   VACCINE

Current status and perspectives on protein-based pneumococcal vaccines

(2013) Michelle Darrieux et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Surface Association of Pht Proteins of Streptococcus pneumoniae

(2013) Charles D. Plumptre et al.   INFECTION AND IMMUNITY

Otitis Media

(2013) Michael E. Pichichero   PEDIATRIC CLINICS OF NORTH AMERICA

Co-colonization by Haemophilus influenzae with Streptococcus pneumoniae enhances pneumococcal-specific antibody response in young children

(2013) Qingfu Xu et al.   VACCINE

Novel Role for the Streptococcus pneumoniae Toxin Pneumolysin in the Assembly of Biofilms

(2013) J. R. Shak et al.   mBio

Neutralizing Antibodies Elicited by a Novel Detoxified Pneumolysin Derivative, PlyD1, Provide Protection against Both Pneumococcal Infection and Lung Injury

(2012) Danielle Salha et al.   INFECTION AND IMMUNITY

Export Requirements of Pneumolysin in Streptococcus pneumoniae

(2012) K. E. Price et al.   JOURNAL OF BACTERIOLOGY

PcpA of Streptococcus pneumoniae mediates adherence to nasopharyngeal and lung epithelial cells and elicits functional antibodies in humans

(2012) M. Nadeem Khan et al.   MICROBES AND INFECTION

Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans

(2012) M. Nadeem Khan et al.   VACCINE

Safety and immunogenicity of a pneumococcal histidine triad protein D vaccine candidate in adults

(2012) Michael Seiberling et al.   VACCINE

Antibody response toStreptococcus pneumoniaeproteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children

(2012) Michael E. Pichichero et al.   Human Vaccines & Immunotherapeutics

Biochemical Characterization of the Histidine Triad Protein PhtD as a Cell Surface Zinc-Binding Protein of Pneumococcus

(2011) Elodie Loisel et al.   BIOCHEMISTRY

Structure-guided Antigen Engineering Yields Pneumolysin Mutants Suitable for Vaccination against Pneumococcal Disease

(2011) Eliud O. Oloo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serotype replacement in disease after pneumococcal vaccination

(2011) Daniel M Weinberger et al.   LANCET

Serum Antibody Response to Five Streptococcus pneumoniae Proteins During Acute Otitis Media in Otitis-prone and Non–otitis-prone Children

(2011) Ravinder Kaur et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

A protein-based pneumococcal vaccine protects rhesus macaques from pneumonia after experimental infection with Streptococcus pneumoniae

(2011) Philippe Denoël et al.   VACCINE

Preclinical Evaluation of the Pht Proteins as Potential Cross-Protective Pneumococcal Vaccine Antigens

(2010) Fabrice Godfroid et al.   INFECTION AND IMMUNITY

Maternal Antibodies to Pneumolysin but Not to Pneumococcal Surface Protein A Delay Early Pneumococcal Carriage in High-Risk Papua New Guinean Infants

(2009) J. P. Francis et al.   Clinical and Vaccine Immunology

Antibodies to Pneumococcal Proteins PhtD, CbpA, and LytC in Filipino Pregnant Women and Their Infants in Relation to Pneumococcal Carriage

(2009) E. Holmlund et al.   Clinical and Vaccine Immunology

RETRACTED: Pneumococcal Surface Adhesin A (PsaA): A Review

(2008) Gowrisankar Rajam et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Pneumolysin: A Double-Edged Sword During the Host-Pathogen Interaction

(2008) Helen Marriott et al.   CURRENT MOLECULAR MEDICINE

Pneumococcal histidine triad proteins are regulated by the Zn2+-dependent repressor AdcR and inhibit complement deposition through the recruitment of complement factor H

(2008) Abiodun D. Ogunniyi et al.   FASEB JOURNAL

Streptococcus pneumoniae Surface Protein PcpA Elicits Protection against Lung Infection and Fatal Sepsis

(2008) D. T. Glover et al.   INFECTION AND IMMUNITY

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY