Streptococcus pneumoniae: transmission, colonization and invasion

Capsule Prolongs Survival of Streptococcus pneumoniae during Starvation

(2018) Shigeto Hamaguchi et al.   INFECTION AND IMMUNITY

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion

(2017) Federico Iovino et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Generalized herd effects and vaccine evaluation: impact of live influenza vaccine on off-target bacterial colonisation

(2017) Michael J. Mina   JOURNAL OF INFECTION

Pneumococcal neuraminidase activates TGF-β signalling

(2017) Nina Gratz et al.   MICROBIOLOGY-SGM

Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease

(2017) Rajendra Kc et al.   MICROBIOLOGY-SGM

Capsule Type and Amount Affect Shedding and Transmission of Streptococcus pneumoniae

(2017) M. Ammar Zafar et al.   mBio

Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae , Resulting in Hypervirulence

(2017) Claudia Trappetti et al.   mBio

Streptococcus pneumoniae Transmission Is Blocked by Type-Specific Immunity in an Infant Mouse Model

(2017) Tonia Zangari et al.   mBio

Molecular Characterization of N-glycan Degradation and Transport in Streptococcus pneumoniae and Its Contribution to Virulence

(2017) Melissa Robb et al.   PLoS Pathogens

Role of Streptococcus pneumoniae Proteins in Evasion of Complement-Mediated Immunity

(2017) Greiciely O. Andre et al.   Frontiers in Microbiology

Novel Analysis of Immune Cells from Nasal Microbiopsy Demonstrates Reliable, Reproducible Data for Immune Populations, and Superior Cytokine Detection Compared to Nasal Wash

(2017) Simon P. Jochems et al.   PLoS One

The Effects of Live Attenuated Influenza Vaccine on Nasopharyngeal Bacteria in Healthy 2 to 4 Year Olds. A Randomized Controlled Trial

(2016) Valtyr Thors et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage

(2016) Shaun H. Pennington et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Streptococcus pneumoniae Senses a Human-like Sialic Acid Profile via the Response Regulator CiaR

(2016) Karina Hentrich et al.   Cell Host & Microbe

A dynamic relationship between mucosal T helper type 17 and regulatory T-cell populations in nasopharynx evolves with age and associates with the clearance of pneumococcal carriage in humans

(2016) A. Mubarak et al.   CLINICAL MICROBIOLOGY AND INFECTION

Prevalence and antibiotic resistance of commensalStreptococcus pneumoniaein nine European countries

(2016) Rachid Y Yahiaoui et al.   Future Microbiology

Diverse Ecological Strategies Are Encoded byStreptococcus pneumoniaeBacteriocin-Like Peptides

(2016) Eric L. Miller et al.   Genome Biology and Evolution

Infant Mouse Model for the Study of Shedding and Transmission during Streptococcus pneumoniae Monoinfection

(2016) M. Ammar Zafar et al.   INFECTION AND IMMUNITY

Neuraminidase A-Exposed Galactose Promotes Streptococcus pneumoniae Biofilm Formation during Colonization

(2016) Krystle A. Blanchette et al.   INFECTION AND IMMUNITY

Free Sialic Acid Acts as a Signal That Promotes Streptococcus pneumoniae Invasion of Nasal Tissue and Nonhematogenous Invasion of the Central Nervous System

(2016) Brandon L. Hatcher et al.   INFECTION AND IMMUNITY

The effects of differences in pspA alleles and capsular types on the resistance of Streptococcus pneumoniae to killing by apolactoferrin

(2016) Shaper Mirza et al.   MICROBIAL PATHOGENESIS

Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage

(2016) E Mitsi et al.   Mucosal Immunology

Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium

(2016) Colin C. Kietzman et al.   Nature Communications

Single Cell Bottlenecks in the Pathogenesis of Streptococcus pneumoniae

(2016) Masamitsu Kono et al.   PLoS Pathogens

TNF Drives Monocyte Dysfunction with Age and Results in Impaired Anti-pneumococcal Immunity

(2016) Alicja Puchta et al.   PLoS Pathogens

Modular Architecture and Unique Teichoic Acid Recognition Features of Choline-Binding Protein L (CbpL) Contributing to Pneumococcal Pathogenesis

(2016) Javier Gutiérrez-Fernández et al.   Scientific Reports

Discovery of Novel Pneumococcal Surface Antigen A (PsaA) Inhibitors Using a Fragment-based Drug Design Approach

(2015) Megha Bajaj et al.   ACS Chemical Biology

Genomic analyses of pneumococci reveal a wide diversity of bacteriocins – including pneumocyclicin, a novel circular bacteriocin

(2015) Carlijn Bogaardt et al.   BMC GENOMICS

Pneumococcal Capsules and Their Types: Past, Present, and Future

(2015) K. Aaron Geno et al.   CLINICAL MICROBIOLOGY REVIEWS

Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection

(2015) Christopher B. Hergott et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil IL-1β Processing Induced by Pneumolysin Is Mediated by the NLRP3/ASC Inflammasome and Caspase-1 Activation and Is Dependent on K+Efflux

(2015) Mausita Karmakar et al.   JOURNAL OF IMMUNOLOGY

Degradation Products of the Extracellular Pathogen Streptococcus pneumoniae Access the Cytosol via Its Pore-Forming Toxin

(2015) Jamie K. Lemon et al.   mBio

Climate induces seasonality in pneumococcal transmission

(2015) Elina Numminen et al.   Scientific Reports

Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking

(2015) Steven J. Siegel et al.   PLoS Pathogens

The adult nasopharyngeal microbiome as a determinant of pneumococcal acquisition

(2015) Amelieke JH Cremers et al.   Microbiome

Early Respiratory Microbiota Composition Determines Bacterial Succession Patterns and Respiratory Health in Children

(2014) Giske Biesbroek et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Influenza Promotes Pneumococcal Growth during Coinfection by Providing Host Sialylated Substrates as a Nutrient Source

(2014) Steven J. Siegel et al.   Cell Host & Microbe

Neutrophil-Toxin Interactions Promote Antigen Delivery and Mucosal Clearance of Streptococcus pneumoniae

(2014) Kathryn A. Matthias et al.   JOURNAL OF IMMUNOLOGY

Antibody blocks acquisition of bacterial colonization through agglutination

(2014) A M Roche et al.   Mucosal Immunology

The co-pathogenesis of influenza viruses with bacteria in the lung

(2014) Jonathan A. McCullers   NATURE REVIEWS MICROBIOLOGY

Effects of Vaccination on Invasive Pneumococcal Disease in South Africa

(2014) Anne von Gottberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Binding of vitronectin and Factor H to Hic contributes to immune evasion of Streptococcus pneumoniae serotype 3

(2014) S. Kohler et al.   THROMBOSIS AND HAEMOSTASIS

A random six-phase switch regulates pneumococcal virulence via global epigenetic changes

(2014) Ana Sousa Manso et al.   Nature Communications

TLR2 Signaling Decreases Transmission of Streptococcus pneumoniae by Limiting Bacterial Shedding in an Infant Mouse Influenza A Co-infection Model

(2014) Aimee L. Richard et al.   PLoS Pathogens

Controlled Human Infection and Rechallenge withStreptococcus pneumoniaeReveals the Protective Efficacy of Carriage in Healthy Adults

(2013) Daniela M. Ferreira et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Biofilm Formation Enhances Fomite Survival of Streptococcus pneumoniae and Streptococcus pyogenes

(2013) Laura R. Marks et al.   INFECTION AND IMMUNITY

AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis inStreptococcus pneumoniae

(2013) Charles D. Plumptre et al.   MOLECULAR MICROBIOLOGY

Pneumococcal IgA1 protease subverts specific protection by human IgA1

(2013) E N Janoff et al.   Mucosal Immunology

Imperfect coordination chemistry facilitates metal ion release in the Psa permease

(2013) Rafael M Couñago et al.   Nature Chemical Biology

Relationships Between Rhinitis Symptoms, Respiratory Viral Infections and Nasopharyngeal Colonization With Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Children Attending Daycare

(2013) Fernanda Rodrigues et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Lack of cross-protection against invasive pneumonia caused by heterologous strains following murine Streptococcus pneumoniae nasopharyngeal colonisation despite whole cell ELISAs showing significant cross-reactive IgG

(2013) Jonathan M. Cohen et al.   VACCINE

Experimental Human Pneumococcal Carriage Augments IL-17A-dependent T-cell Defence of the Lung

(2013) Adam K. A. Wright et al.   PLoS Pathogens

The roles of transition metals in the physiology and pathogenesis of Streptococcus pneumoniae

(2013) Erin S. Honsa et al.   Frontiers in Cellular and Infection Microbiology

Influenza A Induces the Major Secreted Airway Mucin MUC5AC in a Protease–EGFR–Extracellular Regulated Kinase–Sp1–Dependent Pathway

(2012) Diane Barbier et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Identification of Genes That Contribute to the Pathogenesis of Invasive Pneumococcal Disease byIn VivoTranscriptomic Analysis

(2012) Abiodun D. Ogunniyi et al.   INFECTION AND IMMUNITY

Streptococcus pneumoniae Capsular Serotype Invasiveness Correlates with the Degree of Factor H Binding and Opsonization with C3b/iC3b

(2012) Catherine Hyams et al.   INFECTION AND IMMUNITY

Identification of a novel pneumococcal vaccine antigen preferentially expressed during meningitis in mice

(2012) Layla K. Mahdi et al.   JOURNAL OF CLINICAL INVESTIGATION

The Prevalence and Risk Factors for Pneumococcal Colonization of the Nasopharynx among Children in Kilifi District, Kenya

(2012) Osman Abdullahi et al.   PLoS One

A Functional Genomics Approach to Establish the Complement of Carbohydrate Transporters in Streptococcus pneumoniae

(2012) Alessandro Bidossi et al.   PLoS One

Pneumococcal carbohydrate transport: food for thought

(2012) Carolyn M. Buckwalter et al.   TRENDS IN MICROBIOLOGY

Influence of bacterial interactions on pneumococcal colonization of the nasopharynx

(2012) Joshua R. Shak et al.   TRENDS IN MICROBIOLOGY

Human Nasal Challenge with Streptococcus pneumoniae Is Immunising in the Absence of Carriage

(2012) Adam K. A. Wright et al.   PLoS Pathogens

Minimization of Bacterial Size Allows for Complement Evasion and Is Overcome by the Agglutinating Effect of Antibody

(2011) Ankur B. Dalia et al.   Cell Host & Microbe

LuxS Mediates Iron-Dependent Biofilm Formation, Competence, and Fratricide in Streptococcus pneumoniae

(2011) Claudia Trappetti et al.   INFECTION AND IMMUNITY

Nod2 sensing of lysozyme-digested peptidoglycan promotes macrophage recruitment and clearance of S. pneumoniae colonization in mice

(2011) Kimberly M. Davis et al.   JOURNAL OF CLINICAL INVESTIGATION

Synergistic stimulation of type I interferons during influenza virus coinfection promotes Streptococcus pneumoniae colonization in mice

(2011) Shigeki Nakamura et al.   JOURNAL OF CLINICAL INVESTIGATION

BgaA acts as an adhesin to mediate attachment of some pneumococcal strains to human epithelial cells

(2011) D. H. Limoli et al.   MICROBIOLOGY-SGM

Extracellular Matrix Formation Enhances the Ability of Streptococcus pneumoniae to Cause Invasive Disease

(2011) Claudia Trappetti et al.   PLoS One

Streptococcus pneumoniae Is Desiccation Tolerant and Infectious upon Rehydration

(2011) R. L. Walsh et al.   mBio

Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract

(2011) D. Parker et al.   mBio

A Molecular Mechanism for Bacterial Susceptibility to Zinc

(2011) Christopher A. McDevitt et al.   PLoS Pathogens

Influenza A virus facilitates Streptococcus pneumoniae transmission and disease

(2010) Dimitri A. Diavatopoulos et al.   FASEB JOURNAL

Three Surface Exoglycosidases from Streptococcus pneumoniae, NanA, BgaA, and StrH, Promote Resistance to Opsonophagocytic Killing by Human Neutrophils

(2010) A. B. Dalia et al.   INFECTION AND IMMUNITY

Coinfection withHaemophilus influenzaePromotes Pneumococcal Biofilm Formation during Experimental Otitis Media and Impedes the Progression of Pneumococcal Disease

(2010) Kristin E. D. Weimer et al.   JOURNAL OF INFECTIOUS DISEASES

Influenza Enhances Susceptibility to Natural Acquisition of and Disease due toStreptococcus pneumoniaein Ferrets

(2010) Jonathan A. McCullers et al.   JOURNAL OF INFECTIOUS DISEASES

PavB is a surface-exposed adhesin of Streptococcus pneumoniae contributing to nasopharyngeal colonization and airways infections

(2010) Inga Jensch et al.   MOLECULAR MICROBIOLOGY

Pneumococcal modification of host sugars: a major contributor to colonization of the human airway?

(2010) S.J. King   Molecular Oral Microbiology

The Pneumococcal Serine-Rich Repeat Protein Is an Intra-Species Bacterial Adhesin That Promotes Bacterial Aggregation In Vivo and in Biofilms

(2010) Carlos J. Sanchez et al.   PLoS Pathogens

Antibodies to Pneumococcal Proteins PhtD, CbpA, and LytC in Filipino Pregnant Women and Their Infants in Relation to Pneumococcal Carriage

(2009) E. Holmlund et al.   Clinical and Vaccine Immunology

The immunising effect of pneumococcal nasopharyngeal colonisation; protection against future colonisation and fatal invasive disease

(2009) Luke Richards et al.   IMMUNOBIOLOGY

The Streptococcus pneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms

(2009) C. Hyams et al.   INFECTION AND IMMUNITY

Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models

(2009) Carlos J. Orihuela et al.   JOURNAL OF CLINICAL INVESTIGATION

The surface-anchored NanA protein promotes pneumococcal brain endothelial cell invasion

(2009) Satoshi Uchiyama et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Clinical Isolates of Streptococcus pneumoniae Bind the Complement Inhibitor C4b-Binding Protein in a PspC Allele-Dependent Fashion

(2009) A. Dieudonne-Vatran et al.   JOURNAL OF IMMUNOLOGY

Human Neutrophils Kill Streptococcus pneumoniae via Serine Proteases

(2009) A. J. Standish et al.   JOURNAL OF IMMUNOLOGY

Surface-associated lipoprotein PpmA of Streptococcus pneumoniae is involved in colonization in a strain-specific manner

(2009) L. E. Cron et al.   MICROBIOLOGY-SGM

Protection against Nasopharyngeal Colonization by Streptococcus pneumoniae Is Mediated by Antigen-Specific CD4+ T Cells

(2008) K. Trzcinski et al.   INFECTION AND IMMUNITY

The Interaction of Streptococcus pneumoniae with Plasmin Mediates Transmigration across Endothelial and Epithelial Monolayers by Intercellular Junction Cleavage

(2008) C. Attali et al.   INFECTION AND IMMUNITY

Antibodies against PsrP, a NovelStreptococcus pneumoniaeAdhesin, Block Adhesion and Protect Mice against Pneumococcal Challenge

(2008) Lloyd Rose et al.   JOURNAL OF INFECTIOUS DISEASES

Zinc Modifies the Association between Nasopharyngeal Streptococcus pneumoniae Carriage and Risk of Acute Lower Respiratory Infection among Young Children in Rural Nepal

(2008) Christian L. Coles et al.   JOURNAL OF NUTRITION

The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease

(2008) Aras Kadioglu et al.   NATURE REVIEWS MICROBIOLOGY

Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae

(2008) Kimberly M. Davis et al.   PLoS Pathogens