Brain cell type-specific cholesterol metabolism and implications for learning and memory

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

(2021) Xiaohui Li et al.   NEURON

The Role of the ATP-Binding Cassette A1 (ABCA1) in Human Disease

(2021) Leonor Jacobo-Albavera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TREM2, microglia, and Alzheimer’s disease

(2021) Qi Qin et al.   MECHANISMS OF AGEING AND DEVELOPMENT

An overview of the synaptic vesicle lipid composition

(2021) Beyenech Binotti et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nuclear speckle specific hnRNP D-like prevents age- and AD-related cognitive decline by modulating RNA splicing

(2021) Qingyang Zhang et al.   Molecular Neurodegeneration

Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

(2021) Femke M. Feringa et al.   Frontiers in Aging Neuroscience

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications

(2021) Irina A. Pikuleva et al.   Frontiers in Aging Neuroscience

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

(2021) Se-In Lee et al.   Stem Cell Reports

Astrocyte-Neuron Signaling in Synaptogenesis

(2021) Lili Shan et al.   Frontiers in Cell and Developmental Biology

Neuronal cholesterol synthesis is essential for repair of chronically demyelinated lesions in mice

(2021) Stefan A. Berghoff et al.   Cell Reports

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

(2020) Tosha Williams et al.   Molecular Neurodegeneration

Myelin makes memories

(2020) R. Douglas Fields et al.   NATURE NEUROSCIENCE

Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory

(2020) Fei Wang et al.   NATURE NEUROSCIENCE

TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge

(2020) Alicia A. Nugent et al.   NEURON

Microglia mediate forgetting via complement-dependent synaptic elimination

(2020) Chao Wang et al.   SCIENCE

Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory

(2020) Paul Pfeiffer et al.   eLife

Changes in the oligodendrocyte progenitor cell proteome with ageing

(2020) Alerie G de la Fuente et al.   MOLECULAR & CELLULAR PROTEOMICS

Studies on the mechanism of general anesthesia

(2020) Mahmud Arif Pavel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

(2020) Nicholas F. Fitz et al.   Molecular Neurodegeneration

Cholesterol modulates presynaptic and postsynaptic properties of excitatory synaptic transmission

(2020) Miloslav Korinek et al.   Scientific Reports

Alterations in cholesterol metabolism as a risk factor for developing Alzheimer's disease: Potential novel targets for treatment

(2019) Raúl Loera-Valencia et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

ApoE4: an emerging therapeutic target for Alzheimer’s disease

(2019) Mirna Safieh et al.   BMC Medicine

Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis

(2019) Rhonda R. Voskuhl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Metabolism Crosstalk in the Brain: Glia and Neurons

(2019) Casey N. Barber et al.   Frontiers in Cellular Neuroscience

CNS myelination and remyelination depend on fatty acid synthesis by oligodendrocytes

(2019) Penelope Dimas et al.   eLife

Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner

(2019) Diego Adhemar Jaitin et al.   CELL

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

NPC 1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP 46A1 activation

(2019) Daniel N Mitroi et al.   EMBO REPORTS

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes

(2019) Varun Rawat et al.   JOURNAL OF NEUROSCIENCE

The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms

(2019) Natali L. Chanaday et al.   JOURNAL OF NEUROSCIENCE

Remyelination and ageing: Reversing the ravages of time

(2019) Bjoern Neumann et al.   Multiple Sclerosis Journal

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice

(2019) Patrick E. Steadman et al.   NEURON

Cholesterol Metabolism in the Brain and Its Association with Parkinson’s Disease

(2019) Uram Jin et al.   Experimental Neurobiology

Anesthesiology and cognitive impairment: a narrative review of current clinical literature

(2019) Jillian C. Belrose et al.   BMC Anesthesiology

Decreased content, rate of synthesis and export of cholesterol in the brain of apoE knockout mice

(2018) Valéria Sutti Nunes et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

ApoE facilitates the microglial response to amyloid plaque pathology

(2018) Jason D. Ulrich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

(2018) Yingjun Zhao et al.   NEURON

Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

(2018) C.Y. Daniel Lee et al.   NEURON

APOE ε4 is also required in TREM2 R47H variant carriers for Alzheimer's disease to develop

(2018) C. E. Murray et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Defective cholesterol clearance limits remyelination in the aged central nervous system

(2018) Ludovico Cantuti-Castelvetri et al.   SCIENCE

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms

(2018) Bob G. Schultz et al.   Translational Neurodegeneration

TREM2 — a key player in microglial biology and Alzheimer disease

(2018) Tyler K. Ulland et al.   Nature Reviews Neurology

Astrocyte lipid metabolism is critical for synapse development and function in vivo

(2017) Anne-Lieke F. van Deijk et al.   GLIA

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice

(2017) Nicholas F. Fitz et al.   JOURNAL OF ALZHEIMERS DISEASE

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

The α7-nACh nicotinic receptor and its role in memory and selected diseases of the central nervous system

(2017) Urszula Baranowska et al.   Postepy Higieny I Medycyny Doswiadczalnej

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

(2017) Heather A. Ferris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

(2017) Noriko Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease

(2017) Nophar Geifman et al.   Alzheimers Research & Therapy

Oligodendroglial myelination requires astrocyte-derived lipids

(2017) Nutabi Camargo et al.   PLOS BIOLOGY

The Multifaceted Role of SNARE Proteins in Membrane Fusion

(2017) Jing Han et al.   Frontiers in Physiology

Differential expression and function of ABCG1 and ABCG4 during development and aging

(2017) Dragana D. Bojanic et al.   JOURNAL OF LIPID RESEARCH

TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia

(2017) Su-Man Kim et al.   Scientific Reports

Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide

(2017) Agnès Dodacki et al.   Scientific Reports

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance

(2016) Xianyuan Xiang et al.   EMBO Molecular Medicine

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice

(2016) C. Lane-Donovan et al.   JOURNAL OF NEUROSCIENCE

Cholesterol Biosynthesis Supports Myelin Gene Expression and Axon Ensheathment through Modulation of P13K/Akt/mTor Signaling

(2016) E. S. Mathews et al.   JOURNAL OF NEUROSCIENCE

Theories of Memory and Aging: A Look at the Past and a Glimpse of the Future

(2016) Denise C. Park et al.   JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM2 sustains microglial expansion during aging and response to demyelination

(2015) Pietro Luigi Poliani et al.   JOURNAL OF CLINICAL INVESTIGATION

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Membrane lipid rafts and neurobiology: age-related changes in membrane lipids and loss of neuronal function

(2015) Junji Egawa et al.   JOURNAL OF PHYSIOLOGY-LONDON

APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice

(2015) De-shan Liu et al.   Molecular Neurodegeneration

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes

(2015) Catherine Marquer et al.   Molecular Neurodegeneration

Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents

(2014) M. G. Martin et al.   EMBO Molecular Medicine

Cholesterol in brain disease: sometimes determinant and frequently implicated

(2014) M. G. Martin et al.   EMBO REPORTS

Mutation of 3-Hydroxy-3-Methylglutaryl CoA Synthase I Reveals Requirements for Isoprenoid and Cholesterol Synthesis in Oligodendrocyte Migration Arrest, Axon Wrapping, and Myelin Gene Expression

(2014) E. S. Mathews et al.   JOURNAL OF NEUROSCIENCE

Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

(2013) Julius Popp et al.   BIOCHEMICAL PHARMACOLOGY

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Effects of HMG-CoA reductase inhibitors on learning and memory in the guinea pig

(2013) Simran Maggo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

(2013) S. M. Paul et al.   JOURNAL OF NEUROSCIENCE

Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortex

(2013) G. A. Rodriguez et al.   LEARNING & MEMORY

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

ABCA1 influences neuroinflammation and neuronal death

(2013) Joanna M. Karasinska et al.   NEUROBIOLOGY OF DISEASE

Greasing the synaptic vesicle cycle by membrane lipids

(2013) Dmytro Puchkov et al.   TRENDS IN CELL BIOLOGY

Critical Time Window of Neuronal Cholesterol Synthesis during Neurite Outgrowth

(2012) U. Funfschilling et al.   JOURNAL OF NEUROSCIENCE

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Disclosure of cholesterol recognition motifs in transmembrane domains of the human nicotinic acetylcholine receptor

(2011) Carlos J. Baier et al.   Scientific Reports

Cholesterol reduction impairs exocytosis of synaptic vesicles

(2010) A. Linetti et al.   JOURNAL OF CELL SCIENCE

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

(2010) Caroline Dart   JOURNAL OF PHYSIOLOGY-LONDON