Cholesterol Metabolism in the Brain and Its Association with Parkinson’s Disease

Brain cholesterol metabolism and Parkinson's disease

(2019) Xuemei Huang et al.   MOVEMENT DISORDERS

Apolipoprotein E, Receptors, and Modulation of Alzheimer’s Disease

(2018) Na Zhao et al.   BIOLOGICAL PSYCHIATRY

27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons

(2018) Jared Schommer et al.   BMC NEUROSCIENCE

Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process

(2018) Amin Karimi-Moghadam et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson's disease

(2018) Jianhua Zhang et al.   JOURNAL OF NEUROCHEMISTRY

The impact of Apolipoprotein E alleles on cognitive performance in patients with Parkinson's disease

(2018) Pierzchlińska Anna et al.   Neurologia i Neurochirurgia Polska

Brain Cholesterol Metabolism, Oxysterols, and Dementia

(2018) Timothy M. Hughes et al.   JOURNAL OF ALZHEIMERS DISEASE

Higher serum cholesterol and decreased Parkinson's disease risk: A statin-free cohort study

(2018) Violetta Rozani et al.   MOVEMENT DISORDERS

LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation

(2018) Eun-Jin Bae et al.   Nature Communications

α-Synuclein Interacts with Lipoproteins in Plasma

(2017) Fatemeh Nouri Emamzadeh et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration

(2017) Seyed Soheil Saeedi Saravi et al.   METABOLIC BRAIN DISEASE

α-Synuclein Regulates Neuronal Cholesterol Efflux

(2017) Jen-Hsiang Hsiao et al.   MOLECULES

Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson’s disease: Involvement of mitochondrial dysfunctions and oxidative stress

(2017) Rajib Paul et al.   PLoS One

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effects of different isoforms of apoE on aggregation of the α‐synuclein protein implicated in Parkinson’s disease

(2016) Fatemeh Nouri Emamzadeh et al.   NEUROSCIENCE LETTERS

DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression

(2016) Jin-Mo Kim et al.   Scientific Reports

Higher Plasma LDL-Cholesterol is Associated with Preserved Executive and Fine Motor Functions in Parkinson’s Disease

(2016)   Aging and Disease

Cholesterol facilitates interactions between α-synuclein oligomers and charge-neutral membranes

(2015) Andreas van Maarschalkerweerd et al.   FEBS LETTERS

Dietary cholesterol, fats and risk of Parkinson's disease in the Singapore Chinese Health Study

(2015) Louis C Tan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Loss of parkin promotes lipid rafts-dependent endocytosis through accumulating caveolin-1: implications for Parkinson’s disease

(2015) Seon-Heui Cha et al.   Molecular Neurodegeneration

Plasma apolipoprotein A1 associates with age at onset and motor severity in early Parkinson's disease patients

(2015) Christine R. Swanson et al.   MOVEMENT DISORDERS

Isopentenyl diphosphate isomerase, a cholesterol synthesizing enzyme, is localized in Lewy bodies

(2015) Keiko Nakamura et al.   NEUROPATHOLOGY

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways

(2015) Matthew A Mitsche et al.   eLife

Phospholipid transfer protein (PLTP) deficiency impaired blood–brain barrier integrity by increasing cerebrovascular oxidative stress

(2014) Ting Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

HDL and cholesterol handling in the brain

(2014) C. Vitali et al.   CARDIOVASCULAR RESEARCH

Cholesterol in brain disease: sometimes determinant and frequently implicated

(2014) M. G. Martin et al.   EMBO REPORTS

The serum lipid profile of Parkinson's disease patients: a study from China

(2014) Xiaoyan Guo et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Alpha synuclein is transported into and out of the brain by the blood–brain barrier

(2014) Yu-Ting Sui et al.   PEPTIDES

Intravenously Injected Human Apolipoprotein A‐I Rapidly Enters the Central Nervous System via the Choroid Plexus

(2014) Sophie Stukas et al.   Journal of the American Heart Association

Plasma apolipoprotein A1 as a biomarker for Parkinson disease

(2013) Judy K. Qiang et al.   ANNALS OF NEUROLOGY

Recent advances in physiological lipoprotein metabolism

(2013) Indra Ramasamy   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Neuropathological Correlates of Cerebral Multimorbidity

(2013) Johannes Attems et al.   Current Alzheimer Research

DJ-1 Associates with lipid rafts by palmitoylation and regulates lipid rafts-dependent endocytosis in astrocytes

(2013) Kwang Soo Kim et al.   HUMAN MOLECULAR GENETICS

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGCR)

(2013) Laura J. Sharpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles

(2013) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxysterols and Parkinson's disease: Evidence that levels of 24S-hydroxycholesterol in cerebrospinal fluid correlates with the duration of the disease

(2013) Ingemar Björkhem et al.   NEUROSCIENCE LETTERS

Cardiometabolic factors and disease duration in patients with Parkinson’s disease

(2013) Erica Cassani et al.   NUTRITION

Reduced Serum Levels of Triglyceride, Very Low Density Lipoprotein Cholesterol and Apolipoprotein B in Parkinson’s Disease Patients

(2013) Qiang Wei et al.   PLoS One

Lifelong Expression of Apolipoprotein D in the Human Brainstem: Correlation with Reduced Age-Related Neurodegeneration

(2013) Ana Navarro et al.   PLoS One

Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs

(2013) Marco A. S. Baptista et al.   PLoS One

Apolipoprotein E and Apolipoprotein E Receptors: Normal Biology and Roles in Alzheimer Disease

(2013) D. M. Holtzman et al.   Cold Spring Harbor Perspectives in Medicine

A large study reveals no association between APOE and Parkinson's disease

(2012) Monica Federoff et al.   NEUROBIOLOGY OF DISEASE

Transcriptional Activation of Low-Density Lipoprotein Receptor Gene by DJ-1 and Effect of DJ-1 on Cholesterol Homeostasis

(2012) Shiori Yamaguchi et al.   PLoS One

Apolipoprotein E and LRP1 Increase Early in Parkinson's Disease Pathogenesis

(2011) Micha M.M. Wilhelmus et al.   AMERICAN JOURNAL OF PATHOLOGY

The fusogenic tilted peptide (67–78) of α-synuclein is a cholesterol binding domain

(2011) Jacques Fantini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

(2011) Kye-Young Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

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(2011) Noemi Fabelo et al.   MOLECULAR MEDICINE

Serological Profiles of Urate, Paraoxonase-1, Ferritin and Lipid in Parkinson’s Disease: Changes Linked to Disease Progression

(2011) Ken Ikeda et al.   Neurodegenerative Diseases

Serum Cholesterol and the Progression of Parkinson's Disease: Results from DATATOP

(2011) Xuemei Huang et al.   PLoS One

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

(2010) Jean E. Vance et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers

(2010) Chris M. Valdez et al.   HIPPOCAMPUS

Neuronal LRP1 Knockout in Adult Mice Leads to Impaired Brain Lipid Metabolism and Progressive, Age-Dependent Synapse Loss and Neurodegeneration

(2010) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell cholesterol homeostasis: Mediation by active cholesterol

(2010) Theodore L. Steck et al.   TRENDS IN CELL BIOLOGY

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain

(2009) David W. Russell et al.   Annual Review of Biochemistry

Apolipoprotein E receptors in the nervous system

(2009) Joachim Herz   CURRENT OPINION IN LIPIDOLOGY

Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies

(2009) Andrew O. Koob et al.   EXPERIMENTAL NEUROLOGY

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

(2009) Katja Nieweg et al.   JOURNAL OF NEUROCHEMISTRY

Dietary fat intake and risk of Parkinson's disease: A case-control study in Japan

(2009) Yoshihiro Miyake et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Different Patterns of Oxidized Lipid Products in Plasma and Urine of Dengue Fever, Stroke, and Parkinson's Disease Patients: Cautions in the Use of Biomarkers of Oxidative Stress

(2008) Chung-Yung J. Lee et al.   ANTIOXIDANTS & REDOX SIGNALING

Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: Use of an in vitro model

(2008) Fabien Gosselet et al.   BRAIN RESEARCH

Role of ATP-binding cassette transporters in brain lipid transport and neurological disease

(2008) Woojin Scott Kim et al.   JOURNAL OF NEUROCHEMISTRY

Total cholesterol and the risk of Parkinson disease

(2008) G. Hu et al.   NEUROLOGY

Lipid rafts, cholesterol, and the brain

(2008) Zeljka Korade et al.   NEUROPHARMACOLOGY