Remyelination and ageing: Reversing the ravages of time

Dynamics of oligodendrocyte generation in multiple sclerosis

(2019) Maggie S. Y. Yeung et al.   NATURE

Neuronal vulnerability and multilineage diversity in multiple sclerosis

(2019) Lucas Schirmer et al.   NATURE

Central nervous system regeneration is driven by microglia necroptosis and repopulation

(2019) Amy F. Lloyd et al.   NATURE NEUROSCIENCE

The pro-remyelination properties of microglia in the central nervous system

(2019) Amy F. Lloyd et al.   Nature Reviews Neurology

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

(2019) Björn Neumann et al.   Cell Stem Cell

Disease-Modifying Treatment in Progressive Multiple Sclerosis

(2018) John Robert Ciotti et al.   Current Treatment Options in Neurology

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of multiple sclerosis — success from bench to bedside

(2018) Mar Tintore et al.   Nature Reviews Neurology

The adult oligodendrocyte can participate in remyelination

(2018) Ian D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cells promote myelin regeneration in the central nervous system

(2017) Yvonne Dombrowski et al.   NATURE NEUROSCIENCE

Regenerating CNS myelin — from mechanisms to experimental medicines

(2017) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination

(2017) Alerie Guzman De La Fuente et al.   Cell Reports

Pre-Existing Mature Oligodendrocytes Do Not Contribute to Remyelination following Toxin-Induced Spinal Cord Demyelination

(2016) Abbe H. Crawford et al.   AMERICAN JOURNAL OF PATHOLOGY

Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions

(2016) Martina Absinta et al.   JOURNAL OF CLINICAL INVESTIGATION

An inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination

(2016) Michael B. Keough et al.   Nature Communications

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

(2016) Abbe H. Crawford et al.   Cell Reports

Accelerated remyelination during inflammatory demyelination prevents axonal loss and improves functional recovery

(2016) Feng Mei et al.   eLife

Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination

(2015) Muktha S. Natrajan et al.   BRAIN

Sox2 Sustains Recruitment of Oligodendrocyte Progenitor Cells following CNS Demyelination and Primes Them for Differentiation during Remyelination

(2015) Chao Zhao et al.   JOURNAL OF NEUROSCIENCE

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

(2015) S. Moyon et al.   JOURNAL OF NEUROSCIENCE

Oligodendrocytes: Myelination and Axonal Support

(2015) Mikael Simons et al.   Cold Spring Harbor Perspectives in Biology

Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors

(2015) Hélène O. B. Gautier et al.   Nature Communications

A unified cell biological perspective on axon–myelin injury

(2014) Mikael Simons et al.   JOURNAL OF CELL BIOLOGY

Macrophages and CNS remyelination

(2014) Veronique E. Miron et al.   JOURNAL OF NEUROCHEMISTRY

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Astrocyte-Derived Endothelin-1 Inhibits Remyelination through Notch Activation

(2014) Timothy R. Hammond et al.   NEURON

Insufficient OPC migration into demyelinated lesions is a cause of poor remyelination in MS and mouse models

(2013) Amanda Boyd et al.   ACTA NEUROPATHOLOGICA

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Ageing stem and progenitor cells: implications for rejuvenation of the central nervous system

(2013) P. van Wijngaarden et al.   DEVELOPMENT

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Rejuvenation of Regeneration in the Aging Central Nervous System

(2012) Julia M. Ruckh et al.   Cell Stem Cell

Oligodendroglia metabolically support axons and contribute to neurodegeneration

(2012) Youngjin Lee et al.   NATURE

Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity

(2012) Ursula Fünfschilling et al.   NATURE

Neuroprotection and repair in multiple sclerosis

(2012) Robin J. M. Franklin et al.   Nature Reviews Neurology

Remyelination Therapy for Multiple Sclerosis

(2012) Michael B. Keough et al.   Neurotherapeutics

CNS-Resident Glial Progenitor/Stem Cells Produce Schwann Cells as well as Oligodendrocytes during Repair of CNS Demyelination

(2010) Malgorzata Zawadzka et al.   Cell Stem Cell

NG2 Glia Generate New Oligodendrocytes But Few Astrocytes in a Murine Experimental Autoimmune Encephalomyelitis Model of Demyelinating Disease

(2010) R. B. Tripathi et al.   JOURNAL OF NEUROSCIENCE

Retinoid X receptor gamma signaling accelerates CNS remyelination

(2010) Jeffrey K Huang et al.   NATURE NEUROSCIENCE

Myelination and the trophic support of long axons

(2010) Klaus-Armin Nave   NATURE REVIEWS NEUROSCIENCE

Remyelination capacity of the MS brain decreases with disease chronicity

(2009) T. Goldschmidt et al.   NEUROLOGY

Extensive remyelination of the CNS leads to functional recovery

(2009) I. D. Duncan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Remyelination protects axons from demyelination-associated axon degeneration

(2008) K. A. Irvine et al.   BRAIN

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

(2008) T. Kuhlmann et al.   BRAIN

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

(2008) Siming Shen et al.   NATURE NEUROSCIENCE