Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis

(2017) Noriko Itoh et al.   JOURNAL OF NEUROIMMUNOLOGY

ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies

(2016) Anat Boehm-Cagan et al.   JOURNAL OF ALZHEIMERS DISEASE

Why use sex hormones in relapsing-remitting multiple sclerosis? – Authors' reply

(2016) Rhonda Voskuhl et al.   LANCET NEUROLOGY

Estriol combined with glatiramer acetate for women with relapsing-remitting multiple sclerosis: a randomised, placebo-controlled, phase 2 trial

(2016) Rhonda R Voskuhl et al.   LANCET NEUROLOGY

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins

(2016) Anat Boehm-Cagan et al.   PLoS One

Microglia development follows a stepwise program to regulate brain homeostasis

(2016) O. Matcovitch-Natan et al.   SCIENCE

Cortical Volume Loss and Neurologic Dysfunction in Multiple Sclerosis

(2016) Michael K. Racke et al.   JAMA Neurology

Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis

(2016) Allan MacKenzie-Graham et al.   JAMA Neurology

Pathological differences between white and grey matter multiple sclerosis lesions

(2015) Marloes Prins et al.   Annals of the New York Academy of Sciences

Cholesterol in myelin biogenesis and hypomyelinating disorders

(2015) Gesine Saher et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Diversity of astrocyte functions and phenotypes in neural circuits

(2015) Baljit S Khakh et al.   NATURE NEUROSCIENCE

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Cognitive Impairment in Multiple Sclerosis: Clinical, Radiologic and Pathologic Insights

(2014) Gabriele C. DeLuca et al.   BRAIN PATHOLOGY

Lipocalin-2 Protein Deficiency Ameliorates Experimental Autoimmune Encephalomyelitis

(2014) Youngpyo Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Chemokine Expression Regulates Central Nervous System Inflammation and Determines Clinical Phenotype in Autoimmune Encephalomyelitis

(2014) Joshua S. Stoolman et al.   JOURNAL OF IMMUNOLOGY

CCR2-Dependent Dendritic Cell Accumulation in the Central Nervous System during Early Effector Experimental Autoimmune Encephalomyelitis Is Essential for Effector T Cell Restimulation In Situ and Disease Progression

(2014) Benjamin D. Clarkson et al.   JOURNAL OF IMMUNOLOGY

Gender Differences in Multiple Sclerosis

(2014) Sabina Luchetti et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

Simvastatin in patients with progressive multiple sclerosis

(2014) Gavin Giovannoni et al.   LANCET

Hippocampal volume is related to cognitive decline and fornicial diffusion measures in multiple sclerosis

(2014) Katherine A. Koenig et al.   MAGNETIC RESONANCE IMAGING

Bringing CLARITY to gray matter atrophy

(2014) Rory D. Spence et al.   NEUROIMAGE

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

(2014) S. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective effects of testosterone treatment in men with multiple sclerosis

(2014) Florian Kurth et al.   NeuroImage-Clinical

The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination

(2013) Rashad Hussain et al.   BRAIN

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

Oxysterols and cholesterol precursors correlate to magnetic resonance imaging measures of neurodegeneration in multiple sclerosis

(2013) C van de Kraats et al.   Multiple Sclerosis Journal

Transplantation reveals regional differences in oligodendrocyte differentiation in the adult brain

(2013) Francesca Viganò et al.   NATURE NEUROSCIENCE

Effects of central and peripheral inflammation on hippocampal synaptic plasticity

(2013) Massimiliano Di Filippo et al.   NEUROBIOLOGY OF DISEASE

Inflammation Subverts Hippocampal Synaptic Plasticity in Experimental Multiple Sclerosis

(2013) Robert Nisticò et al.   PLoS One

Cell type-specific genes show striking and distinct patterns of spatial expression in the mouse brain

(2013) Y. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT1, NF-κB and ERKs play a role in the induction of lipocalin-2 expression in adipocytes

(2013) Peng Zhao et al.   Molecular Metabolism

Mechanisms regulating regional localization of inflammation during CNS autoimmunity

(2012) Emily Pierson et al.   IMMUNOLOGICAL REVIEWS

Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in the Hippocampus during Autoimmune Demyelinating Disease

(2012) M. O. Ziehn et al.   JOURNAL OF NEUROSCIENCE

Estriol preserves synaptic transmission in the hippocampus during autoimmune demyelinating disease

(2012) Marina O Ziehn et al.   LABORATORY INVESTIGATION

Sex-related factors in multiple sclerosis susceptibility and progression

(2012) Rhonda R. Voskuhl et al.   Nature Reviews Neurology

Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration

(2011) Rory D. Spence et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Lipocalin-2 Is a Chemokine Inducer in the Central Nervous System

(2011) Shinrye Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Risk factors for and management of cognitive dysfunction in multiple sclerosis

(2011) Ralph H. B. Benedict et al.   Nature Reviews Neurology

Neurosteroid and GABA-A receptor alterations in Alzheimer's disease, Parkinson's disease and multiple sclerosis

(2011) S. Luchetti et al.   NEUROSCIENCE

Neuroprotection mediated through estrogen receptor-  in astrocytes

(2011) R. D. Spence et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new HDL mimetic peptide that stimulates cellular cholesterol efflux with high efficiency greatly reduces atherosclerosis in mice

(2010) John K. Bielicki et al.   JOURNAL OF LIPID RESEARCH

Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE

(2010) Marina O Ziehn et al.   LABORATORY INVESTIGATION

Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus

(2009) Lars Fester et al.   HIPPOCAMPUS

Initiation and Progression of Axonopathy in Experimental Autoimmune Encephalomyelitis

(2009) A. M. Soulika et al.   JOURNAL OF NEUROSCIENCE

Reactive Astrocytes Form Scar-Like Perivascular Barriers to Leukocytes during Adaptive Immune Inflammation of the CNS

(2009) R. R. Voskuhl et al.   JOURNAL OF NEUROSCIENCE

Lipocalin-2 Is an Autocrine Mediator of Reactive Astrocytosis

(2009) S. Lee et al.   JOURNAL OF NEUROSCIENCE

Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels

(2009) Silvia Giatti et al.   NEUROCHEMISTRY INTERNATIONAL

Purkinje cell loss in experimental autoimmune encephalomyelitis

(2009) Allan MacKenzie-Graham et al.   NEUROIMAGE

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues

(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional hippocampal atrophy in multiple sclerosis

(2008) N. L. Sicotte et al.   BRAIN

Cognitive impairment in multiple sclerosis

(2008) Nancy D Chiaravalloti et al.   LANCET NEUROLOGY

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE