Re-establishing the comprehension of phytomedicine and nanomedicine in inflammation-mediated cancer signaling

Role of JAK/STAT3 Signaling in the Regulation of Metastasis, the Transition of Cancer Stem Cells, and Chemoresistance of Cancer by Epithelial–Mesenchymal Transition

(2020) Wook Jin   Cells

Targeting Aberrant RAS/RAF/MEK/ERK Signaling for Cancer Therapy

(2020) Ufuk Degirmenci et al.   Cells

Nano phytomedicine based delivery system for CNS disease

(2020) Mohammed Asadullah Jahangir et al.   CURRENT DRUG METABOLISM

Gold Nanocomplex Strongly Modulates the PI3K/Akt Pathway and Other Pathways in MCF-7 Breast Cancer Cell Line

(2020) Nouf N. Mahmoud et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small molecules, big impact: 20 years of targeted therapy in oncology

(2020) Philippe L Bedard et al.   LANCET

Cancer Nanomedicine

(2020) Clare Hoskins   Cancers

JAK-STAT Signalling Pathway in Cancer

(2020) Andrew J. Brooks et al.   Cancers

Capmatinib in MET Exon 14–Mutated or MET-Amplified Non–Small-Cell Lung Cancer

(2020) Jürgen Wolf et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical cancer nanomedicine

(2019) Joy Wolfram et al.   Nano Today

PI3K isoforms in cell signalling and vesicle trafficking

(2019) Benoit Bilanges et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting mTOR for cancer therapy

(2019) Hui Hua et al.   Journal of Hematology & Oncology

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside

(2019) Ali S. Alzahrani   SEMINARS IN CANCER BIOLOGY

Selenium nanoparticles for targeted stroke therapy through modulation of inflammatory and metabolic signaling

(2019) Hamed Amani et al.   Scientific Reports

Recent nanotechnological interventions targeting PI3K/Akt/mTOR pathway: A focus on breast cancer

(2019) VarRuchi Sharma et al.   SEMINARS IN CANCER BIOLOGY

Nanoparticles Targeting STATs in Cancer Therapy

(2019) Milad Ashrafizadeh et al.   Cells

Phytofabrication of Nanoparticles as Novel Drugs for Anticancer Applications

(2019) Qi-Yao Wei et al.   MOLECULES

A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment

(2019) Huynh et al.   Biomolecules

Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials

(2019) Robert C Doebele et al.   LANCET ONCOLOGY

Chronic inflammation in the etiology of disease across the life span

(2019) David Furman et al.   NATURE MEDICINE

Dual-targeting Wnt and uPA receptors using peptide conjugated ultra-small nanoparticle drug carriers inhibited cancer stem-cell phenotype in chemo-resistant breast cancer

(2018) Jasmine Miller-Kleinhenz et al.   BIOMATERIALS

Pan-RAF and MEK vertical inhibition enhances therapeutic response in non-V600 BRAF mutant cells

(2018) Eszter Molnár et al.   BMC CANCER

Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma

(2018) Huinan Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Quizartinib, an FLT3 inhibitor, as monotherapy in patients with relapsed or refractory acute myeloid leukaemia: an open-label, multicentre, single-arm, phase 2 trial

(2018) Jorge Cortes et al.   LANCET ONCOLOGY

Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

(2018) Alexander Drilon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Baicalein and baicalin inhibit colon cancer using two distinct fashions of apoptosis and senescence

(2018) Jie Dou et al.   Oncotarget

Chitosan/poly (lactic acid)-coated piceatannol nanoparticles exert an in vitro apoptosis activity on liver, lung and breast cancer cell lines

(2018) Jeevitha Dhanapal et al.   Artificial Cells Nanomedicine and Biotechnology

Downregulating CD26/DPPIV by apigenin modulates the interplay between Akt and Snail/Slug signaling to restrain metastasis of lung cancer with multiple EGFR statuses

(2018) Jer-Hwa Chang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Inflammation and Cancer: In Medio Stat Nano

(2018) Roberto Molinaro et al.   CURRENT MEDICINAL CHEMISTRY

Duvelisib: a phosphoinositide-3 kinase δ/γ inhibitor for chronic lymphocytic leukemia

(2017) Hima V. Vangapandu et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Effective melanoma cancer suppression by iontophoretic co-delivery of STAT3 siRNA and imatinib using gold nanoparticles

(2017) Suman Labala et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

JAK inhibition as a therapeutic strategy for immune and inflammatory diseases

(2017) Daniella M. Schwartz et al.   NATURE REVIEWS DRUG DISCOVERY

Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling

(2017) Ling Huang et al.   Oncology Letters

Concomitant activation of ETS-like transcription factor-1 and Death Receptor-5 via extracellular signal-regulated kinase in withaferin A-mediated inhibition of hepatocarcinogenesis in mice

(2017) Panjamurthy Kuppusamy et al.   Scientific Reports

Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer

(2017) Wei Wen et al.   Scientific Reports

Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines

(2017) Mariia Lunova et al.   Scientific Reports

Highly Stable Fluorinated Nanocarriers with iRGD for Overcoming the Stability Dilemma and Enhancing Tumor Penetration in an Orthotopic Breast Cancer

(2016) Shengnan Ma et al.   ACS Applied Materials & Interfaces

Selective AKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells

(2016) Patrizia Malkomes et al.   ANNALS OF SURGICAL ONCOLOGY

Impact of protein pre-coating on the protein corona composition and nanoparticle cellular uptake

(2016) Vahid Mirshafiee et al.   BIOMATERIALS

Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells

(2016) Zhen Li et al.   CANCER LETTERS

Gold nanoparticle-conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasivenessviaEGFR/VEGFR-2-mediated pathway in breast cancer

(2016) S. Balakrishnan et al.   CELL PROLIFERATION

Molecular targets of luteolin in cancer

(2016) Muobarak J. Tuorkey   EUROPEAN JOURNAL OF CANCER PREVENTION

Cancer nanomedicines: oversold or underappreciated?

(2016) Roy van der Meel et al.   Expert Opinion on Drug Delivery

An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer

(2016) Sanaz Koosha et al.   International Journal of Medical Sciences

Co-delivery of curcumin and STAT3 siRNA using deformable cationic liposomes to treat skin cancer

(2016) Anup Jose et al.   JOURNAL OF DRUG TARGETING

Polymeric nanoparticles for targeted drug delivery system for cancer therapy

(2016) Farha Masood   Materials Science & Engineering C-Materials for Biological Applications

Emodin Inhibits Breast Cancer Growth by Blocking the Tumor-Promoting Feedforward Loop between Cancer Cells and Macrophages

(2016) S. Iwanowycz et al.   MOLECULAR CANCER THERAPEUTICS

Emodin induces hepatocellular carcinoma cell apoptosis through MAPK and PI3K/AKT signaling pathways in vitro and in vivo

(2016) Wanfu Lin et al.   ONCOLOGY REPORTS

Thymoquinone inhibits proliferation in gastric cancerviathe STAT3 pathwayin vivoandin vitro

(2016) Wen-Qian Zhu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells

(2016) Suman Suman et al.   Oncotarget

Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis

(2016) Sugong Chen et al.   Oncotarget

Pterostilbene induces apoptosis and cell cycle arrest in diffuse large B-cell lymphoma cells

(2016) Yuanyuan Kong et al.   Scientific Reports

The NF-κB Pathway and Cancer Stem Cells

(2016) Amanda Rinkenbaugh et al.   Cells

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

(2016) Ramadevi Subramani et al.   Scientific Reports

Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia

(2015) Manli Song et al.   ACS Nano

Dendrosomal Curcumin Suppresses Metastatic Breast Cancer in Mice by Changing M1/M2 Macrophage Balance in the Tumor Microenvironment

(2015) Sadaf Shiri et al.   Asian Pacific Journal of Cancer Prevention

Baicalin and baicalein inhibit transforming growth factor-β1-mediated epithelial-mesenchymal transition in human breast epithelial cells

(2015) Heesung Chung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Retinoid X receptor α enhances human cholangiocarcinoma growth through simultaneous activation of Wnt/β-catenin and nuclear factor-κB pathways

(2015) Gui-Li Huang et al.   CANCER SCIENCE

Immunosuppression associated with chronic inflammation in the tumor microenvironment

(2015) Dingzhi Wang et al.   CARCINOGENESIS

The nanoparticle biomolecule corona: lessons learned – challenge accepted?

(2015) D. Docter et al.   CHEMICAL SOCIETY REVIEWS

MicroRNA-26b inhibits cell proliferation and cytokine secretion in human RASF cells via the Wnt/GSK-3β/β-catenin pathway

(2015) Jiling Sun et al.   Diagnostic Pathology

Long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-κB pathway and JAK/STAT3 pathway to inhibit TNF-α and IFN-γ in hepatocellular carcinoma

(2015) Pingbo Xu et al.   EXPERIMENTAL CELL RESEARCH

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

Mitochondrial dysfunction induces EMT through the TGF-β/Smad/Snail signaling pathway in Hep3B hepatocellular carcinoma cells

(2015) EUI-YEUN YI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

STAT3 Decoy Oligodeoxynucleotides-Loaded Solid Lipid Nanoparticles Induce Cell Death and Inhibit Invasion in Ovarian Cancer Cells

(2015) Yanhui Ma et al.   PLoS One

Liposomal delivery of dexamethasone attenuates prostate cancer bone metastatic tumor growth In Vivo

(2015) Jan Kroon et al.   PROSTATE

Andrographolide inhibits hypoxia-inducible factor-1 through phosphatidylinositol 3-kinase/AKT pathway and suppresses breast cancer growth

(2015) Jie Li et al.   OncoTargets and Therapy

Hibiscus sabdariffa Leaf Extract Inhibits Human Prostate Cancer Cell Invasion via Down-Regulation of Akt/NF-kB/MMP-9 Pathway

(2015) Chun-Tang Chiu et al.   Nutrients

JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor

(2015) Fu-quan Zhang et al.   Oncotarget

MiR-1207 overexpression promotes cancer stem cell–like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway

(2015) Geyan Wu et al.   Oncotarget

Magnetoliposomes Loaded with Poly-Unsaturated Fatty Acids as Novel Theranostic Anti-Inflammatory Formulations

(2015) Daniel Calle et al.   Theranostics

Ferulic acid combined with aspirin demonstrates chemopreventive potential towards pancreatic cancer when delivered using chitosan-coated solid-lipid nanoparticles

(2015) Arvind Thakkar et al.   Cell and Bioscience

An overview of nanotoxicity and nanomedicine research: principles, progress and implications for cancer therapy

(2015) Ye Wang et al.   Journal of Materials Chemistry B

Multifunctional Nanomaterials and Their Applications in Drug Delivery and Cancer Therapy

(2015) Mathangi Srinivasan et al.   Nanomaterials

Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis

(2015) In Hye Jung et al.   NEOPLASIA

Mitogen-Activated Protein Kinase Signal Transduction in Solid Tumors

(2014) Yuan-Yuan Lei et al.   Asian Pacific Journal of Cancer Prevention

Cancer and systemic inflammation: treat the tumour and treat the host

(2014) C S D Roxburgh et al.   BRITISH JOURNAL OF CANCER

Emerging roles of radioresistance in prostate cancer metastasis and radiation therapy

(2014) Lei Chang et al.   CANCER AND METASTASIS REVIEWS

6-Shogaol from Dried Ginger Inhibits Growth of Prostate Cancer Cells Both In Vitro and In Vivo through Inhibition of STAT3 and NF- B Signaling

(2014) A. Saha et al.   Cancer Prevention Research

Functional p38 MAPK Identified by Biomarker Profiling of Pancreatic Cancer Restrains Growth through JNK Inhibition and Correlates with Improved Survival

(2014) Y. Zhong et al.   CLINICAL CANCER RESEARCH

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

(2014) Duan et al.   International Journal of Nanomedicine

The enhanced longevity and liver targetability of Paclitaxel by hybrid liposomes encapsulating Paclitaxel-conjugated gold nanoparticles

(2014) Quan-Ying Bao et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A novel ibuprofen derivative with anti-lung cancer properties: Synthesis, formulation, pharmacokinetic and efficacy studies

(2014) Ka-Wing Cheng et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis

(2014) Matjaz Rokavec et al.   JOURNAL OF CLINICAL INVESTIGATION

Quercetin reverses EGF-induced epithelial to mesenchymal transition and invasiveness in prostate cancer (PC-3) cell line via EGFR/PI3K/Akt pathway

(2014) Firdous Ahmad Bhat et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Targeted Nanogel Conjugate for Improved Stability and Cellular Permeability of Curcumin: Synthesis, Pharmacokinetics, and Tumor Growth Inhibition

(2014) Xin Wei et al.   MOLECULAR PHARMACEUTICS

Lipid–polymer nanoparticles encapsulating curcumin for modulating the vascular deposition of breast cancer cells

(2014) Anna L. Palange et al.   Nanomedicine-Nanotechnology Biology and Medicine

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

(2014) V De Simone et al.   ONCOGENE

Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

(2014) N Hasima et al.   Cell Death & Disease

Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines

(2013) Yan Yan et al.   ACS Nano

Significance of mTOR Signaling and Its Inhibitor Against Cancer Stem-Like Cells in Colorectal Cancer

(2013) Zerong Cai et al.   ANNALS OF SURGICAL ONCOLOGY

Combinational delivery of c-myc siRNA and nucleoside analogs in a single, synthetic nanocarrier for targeted cancer therapy

(2013) Yuan Zhang et al.   BIOMATERIALS

Amino-functionalized nanoparticles as inhibitors of mTOR and inducers of cell cycle arrest in leukemia cells

(2013) Cornelia Loos et al.   BIOMATERIALS

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

Targeting the PI3K/AKT/mTOR and Raf/MEK/ERK pathways in the treatment of breast cancer

(2013) Kamal S. Saini et al.   CANCER TREATMENT REVIEWS

[6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2

(2013) Myoung Ok Kim et al.   CARCINOGENESIS

Molecular Pathways: JAK/STAT Pathway: Mutations, Inhibitors, and Resistance

(2013) A. Quintas-Cardama et al.   CLINICAL CANCER RESEARCH

Influence of curcumin-loaded cationic liposome on anticancer activity for cervical cancer therapy

(2013) Nattika Saengkrit et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Editorial (Hot Topic Potential Value and Limitation of Dual Inhibitors of PI3K and mTOR in the Treatment of Cancer)

(2013) Jiezhong Chen   CURRENT CANCER DRUG TARGETS

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Inhibition of p38 MAPK sensitizes tumour cells to cisplatin-induced apoptosis mediated by reactive oxygen species and JNK

(2013) Lorena Pereira et al.   EMBO Molecular Medicine

Gellan gum nanohydrogel containing anti-inflammatory and anti-cancer drugs: a multi-drug delivery system for a combination therapy in cancer treatment

(2013) Giorgia D’Arrigo et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Pronounced induction of endoplasmic reticulum stress and tumor suppression by surfactant-free poly (lactic-co-glycolic acid) nanoparticles via modulation of the PI3K signaling pathway

(2013) Chia-Cheng Hou et al.   International Journal of Nanomedicine

Ketoprofen-loaded polymeric nanocapsules selectively inhibit cancer cell growth in vitro and in preclinical model of glioblastoma multiforme

(2013) Elita F. da Silveira et al.   INVESTIGATIONAL NEW DRUGS

Effective down-regulation of signal transducer and activator of transcription 3 (STAT3) by polyplexes of siRNA and lipid-substituted polyethyleneimine for sensitization of breast tumor cells to conventional chemotherapy

(2013) Arash Falamarzian et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models

(2013) Ningshu Liu et al.   MOLECULAR CANCER THERAPEUTICS

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Phytoagents for Cancer Management: Regulation of Nucleic Acid Oxidation, ROS, and Related Mechanisms

(2013) Wai-Leng Lee et al.   Oxidative Medicine and Cellular Longevity

Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway

(2013) Jiri Polivka et al.   PHARMACOLOGY & THERAPEUTICS

Synergistic apoptotic effect of crocin and cisplatin on osteosarcoma cells via caspase induced apoptosis

(2013) Xiucheng Li et al.   TOXICOLOGY LETTERS

Genomic Instability in Cancer

(2013) T. Abbas et al.   Cold Spring Harbor Perspectives in Biology

Chemiluminescent and Antioxidant Micelles as Theranostic Agents for Hydrogen Peroxide Associated-Inflammatory Diseases

(2012) Sujin Cho et al.   ADVANCED FUNCTIONAL MATERIALS

Mesoporous Silica-Coated Gold Nanorods as a Light-Mediated Multifunctional Theranostic Platform for Cancer Treatment

(2012) Zhenjiang Zhang et al.   ADVANCED MATERIALS

Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats

(2012) Yukun Zhang et al.   BRITISH JOURNAL OF NUTRITION

Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF

(2012) Sanchita Roy et al.   Journal of Hematology & Oncology

Efficient inhibition of intraperitoneal ovarian cancer growth in nude mice by liposomal delivery of short hairpin RNA against STAT3

(2012) Qingyuan Jiang et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

(2012) Axel Hauschild et al.   LANCET

High Resolution Fluorescence Imaging of Cancers Using Lanthanide Ion-Doped Upconverting Nanocrystals

(2012) Rafik Naccache et al.   Cancers

Surface Engineering of Iron Oxide Nanoparticles for Targeted Cancer Therapy

(2011) Forrest M. Kievit et al.   ACCOUNTS OF CHEMICAL RESEARCH

Gold nanoparticles in cancer therapy

(2011) Zhao-Zhin Joanna Lim et al.   ACTA PHARMACOLOGICA SINICA

pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates

(2011) Arnaud E. Felber et al.   ADVANCED DRUG DELIVERY REVIEWS

Multifunctional nanoparticles for upconversion luminescence/MR multimodal imaging and magnetically targeted photothermal therapy

(2011) Liang Cheng et al.   BIOMATERIALS

Nanomedicine in cancer therapy: Innovative trends and prospects

(2011) Elvin Blanco et al.   CANCER SCIENCE

Design of biocompatible dendrimers for cancer diagnosis and therapy: current status and future perspectives

(2011) Yiyun Cheng et al.   CHEMICAL SOCIETY REVIEWS

A Novel Kinase Inhibitor, INCB28060, Blocks c-MET-Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3

(2011) X. Liu et al.   CLINICAL CANCER RESEARCH

Design and engineering of nanogels for cancer treatment

(2011) Murali Mohan Yallapu et al.   DRUG DISCOVERY TODAY

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24– stem cell–like breast cancer cells in human tumors

(2011) Lauren L.C. Marotta et al.   JOURNAL OF CLINICAL INVESTIGATION

Inorganic nanoparticles for cancer imaging and therapy

(2011) Huang-Chiao Huang et al.   JOURNAL OF CONTROLLED RELEASE

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

Rapamycin passes the torch: a new generation of mTOR inhibitors

(2011) Don Benjamin et al.   NATURE REVIEWS DRUG DISCOVERY

A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt–TSC2-mTOR signaling

(2011) H-L Liu et al.   Cell Death & Disease

PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network

(2011) Haoqiang Ying et al.   Cancer Discovery

An overview of the c-MET signaling pathway

(2011) Shawna Leslie Organ et al.   Therapeutic Advances in Medical Oncology

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The relationship between the presence and site of cancer, an inflammation-based prognostic score and biochemical parameters. Initial results of the Glasgow Inflammation Outcome Study

(2010) M J Proctor et al.   BRITISH JOURNAL OF CANCER

Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation

(2010) Guobin He et al.   CANCER CELL

Blueberry Phytochemicals Inhibit Growth and Metastatic Potential of MDA-MB-231 Breast Cancer Cells through Modulation of the Phosphatidylinositol 3-Kinase Pathway

(2010) Lynn S. Adams et al.   CANCER RESEARCH

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

NF-κB and STAT3 – key players in liver inflammation and cancer

(2010) Guobin He et al.   CELL RESEARCH

Inflammation and Colon Cancer

(2010) Janoš Terzić et al.   GASTROENTEROLOGY

Molecular alterations of EGFR and PTEN in prostate cancer: association with high-grade and advanced-stage carcinomas

(2010) Silvia de Muga et al.   MODERN PATHOLOGY

STAT3 Silencing in Dendritic Cells by siRNA Polyplexes Encapsulated in PLGA Nanoparticles for the Modulation of Anticancer Immune Response

(2010) Aws Alshamsan et al.   MOLECULAR PHARMACEUTICS

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Wnt signaling in stem and cancer stem cells

(2010) Peter Wend et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The suppression of lung tumorigenesis by aerosol-delivered folate–chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway

(2009) Hu-Lin Jiang et al.   BIOMATERIALS

Wnt/ -Catenin Signaling Regulates Cytokine-Induced Human Inducible Nitric Oxide Synthase Expression by Inhibiting Nuclear Factor- B Activation in Cancer Cells

(2009) Q. Du et al.   CANCER RESEARCH

Granulocyte Macrophage Colony-Stimulating Factor Inhibits Breast Cancer Growth and Metastasis by Invoking an Anti-Angiogenic Program in Tumor-Educated Macrophages

(2009) T. D. Eubank et al.   CANCER RESEARCH

High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B

(2009) Vincent Wai-Sun Wong et al.   INTERNATIONAL JOURNAL OF CANCER

PTENgenomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer

(2009) Kanishka Sircar et al.   JOURNAL OF PATHOLOGY

PKC Phosphorylation of TRAF2 Mediates IKKα/β Recruitment and K63-Linked Polyubiquitination

(2009) Shitao Li et al.   MOLECULAR CELL

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy

(2009) S. Basu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PAMAM Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death through the Akt-TSC2-mTOR Signaling Pathway

(2009) C. Li et al.   Journal of Molecular Cell Biology

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

JNK signaling in apoptosis

(2008) D N Dhanasekaran et al.   ONCOGENE