Selective AKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells

Selective targeting of human colon cancer stem-like cells by the mTOR inhibitor Torin-1

(2015) Maria Giovanna Francipane et al.   Oncotarget

Akt inhibitor MK-2206 promotes anti-tumor activity and cell death by modulation of AIF and Ezrin in colorectal cancer

(2014) Ekta Agarwal et al.   BMC CANCER

CD44v6 Is a Marker of Constitutive and Reprogrammed Cancer Stem Cells Driving Colon Cancer Metastasis

(2014) Matilde Todaro et al.   Cell Stem Cell

Colorectal Cancer Stem Cells: From the Crypt to the Clinic

(2014) Ann Zeuner et al.   Cell Stem Cell

Phase 1 trial of the oral AKT inhibitor MK-2206 plus carboplatin/paclitaxel, docetaxel, or erlotinib in patients with advanced solid tumors

(2014) L Molife et al.   Journal of Hematology & Oncology

Significance of mTOR Signaling and Its Inhibitor Against Cancer Stem-Like Cells in Colorectal Cancer

(2013) Zerong Cai et al.   ANNALS OF SURGICAL ONCOLOGY

Targeting AKT with the allosteric AKT inhibitor MK-2206 in non-small cell lung cancer cells with acquired resistance to cetuximab

(2013) Mari Iida et al.   CANCER BIOLOGY & THERAPY

Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells

(2012) Benjamin Blaser et al.   BMC CANCER

Cancer treatment and survivorship statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibition of AKT with the Orally Active Allosteric AKT Inhibitor, MK-2206, Sensitizes Endometrial Cancer Cells to Progestin

(2012) Alok Pant et al.   PLoS One

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

The Akt-Specific Inhibitor MK2206 Selectively Inhibits Thyroid Cancer Cells Harboring Mutations That Can Activate the PI3K/Akt Pathway

(2011) Ruixin Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors

(2011) Timothy A. Yap et al.   JOURNAL OF CLINICAL ONCOLOGY

Colon Cancer Stem Cells: Promise of Targeted Therapy

(2010) Matilde Todaro et al.   GASTROENTEROLOGY

Novel Expression Patterns of PI3K/Akt/mTOR Signaling Pathway Components in Colorectal Cancer

(2010) Sara M. Johnson et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Cancer stem cells in solid tumors

(2010) Patrick C. Hermann et al.   SEMINARS IN CANCER BIOLOGY

Gastrointestinal stem cells in development and cancer

(2008) S Brabletz et al.   JOURNAL OF PATHOLOGY

MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis

(2008) Ulrike Stein et al.   NATURE MEDICINE