The NF-κB Pathway and Cancer Stem Cells

Preferential expression of functional IL-17R in glioma stem cells: potential role in self-renewal

(2016) Prahlad Parajuli et al.   Oncotarget

Inhibition of IKK/NF-κB Signaling Enhances Differentiation of Mesenchymal Stromal Cells from Human Embryonic Stem Cells

(2016) Peng Deng et al.   Stem Cell Reports

Targeting NF- B in glioblastoma: A therapeutic approach

(2016) D. Friedmann-Morvinski et al.   Science Advances

Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF- B Signaling Pathway

(2015) N. Ohtsu et al.   CANCER RESEARCH

Let-7a regulates mammosphere formation capacity through Ras/NF-κB and Ras/MAPK/ERK pathway in breast cancer stem cells

(2015) Chongwen Xu et al.   CELL CYCLE

Prostaglandin E2 Promotes Colorectal Cancer Stem Cell Expansion and Metastasis in Mice

(2015) Dingzhi Wang et al.   GASTROENTEROLOGY

Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells

(2015) A. W. Lambert et al.   MOLECULAR CANCER RESEARCH

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

(2015) Yinghui Li et al.   NATURE CELL BIOLOGY

CD133 and DNA-PK regulate MDR1 via the PI3K- or Akt-NF-κB pathway in multidrug-resistant glioblastoma cells in vitro

(2015) G Xi et al.   ONCOGENE

Perspective: Cooperation of Nanog, NF-κΒ, and CXCR4 in a regulatory network for directed migration of cancer stem cells

(2015) Masoumeh Es-haghi et al.   TUMOR BIOLOGY

IRAK1 is a therapeutic target that drives breast cancer metastasis and resistance to paclitaxel

(2015) Zhen Ning Wee et al.   Nature Communications

Osteopontin promotes a cancer stem cell-like phenotype in hepatocellular carcinoma cells via an integrin–NF-κB–HIF-1α pathway

(2015) Lei Cao et al.   Oncotarget

TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells

(2015) Dayson Moreira et al.   Oncotarget

The NFκB inhibitor, SN50, induces differentiation of glioma stem cells and suppresses their oncogenic phenotype

(2014) Li Zhang et al.   CANCER BIOLOGY & THERAPY

Activin Upregulation by NF- B Is Required to Maintain Mesenchymal Features of Cancer Stem-like Cells in Non-Small Cell Lung Cancer

(2014) J. J. Wamsley et al.   CANCER RESEARCH

Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis

(2014) Jimmy L. Zhao et al.   Cell Stem Cell

Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα)

(2014) Han C. Dan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity

(2014) Yuki Kagoya et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutant p53 Reprograms TNF Signaling in Cancer Cells through Interaction with the Tumor Suppressor DAB2IP

(2014) Giulio Di Minin et al.   MOLECULAR CELL

C11orf95–RELA fusions drive oncogenic NF-κB signalling in ependymoma

(2014) Matthew Parker et al.   NATURE

An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition

(2014) Laetitia Seguin et al.   NATURE CELL BIOLOGY

NF-κB Inducing Kinase, a Central Signaling Component of the Non-Canonical Pathway of NF-κB, Contributes to Ovarian Cancer Progression

(2014) Masaya Uno et al.   PLoS One

A Phase I Clinical Trial of Systemically Delivered NEMO Binding Domain Peptide in Dogs with Spontaneous Activated B-Cell like Diffuse Large B-Cell Lymphoma

(2014) Georges Habineza Ndikuyeze et al.   PLoS One

NF-κB Signaling Pathway Confers Neuroblastoma Cells Migration and Invasion Ability via the Regulation of CXCR4

(2014) Kun Yang   MEDICAL SCIENCE MONITOR

Autocrine TNF-  production supports CML stem and progenitor cell survival and enhances their proliferation

(2013) P. Gallipoli et al.   BLOOD

Deletion of the NF- B subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function

(2013) S. J. Stein et al.   BLOOD

A NIK-IKKα Module Expands ErbB2-Induced Tumor-Initiating Cells by Stimulating Nuclear Export of p27/Kip1

(2013) Weizhou Zhang et al.   CANCER CELL

Mutant p53 Prolongs NF-κB Activation and Promotes Chronic Inflammation and Inflammation-Associated Colorectal Cancer

(2013) Tomer Cooks et al.   CANCER CELL

A DNA Methylation Prognostic Signature of Glioblastoma: Identification of NPTX2-PTEN-NF- B Nexus

(2013) S. Shukla et al.   CANCER RESEARCH

TLR2 enhances ovarian cancer stem cell self-renewal and promotes tumor repair and recurrence

(2013) Ilana Chefetz et al.   CELL CYCLE

ROS Production and NF-κB Activation Triggered by RAC1 Facilitate WNT-Driven Intestinal Stem Cell Proliferation and Colorectal Cancer Initiation

(2013) Kevin B. Myant et al.   Cell Stem Cell

IKK interacts with rictor and regulates mTORC2

(2013) Yuanfei Xu et al.   CELLULAR SIGNALLING

Constitutive Activation of Signal Transducer and Activator of Transcription 3 (STAT3) and Nuclear Factor κB Signaling in Glioblastoma Cancer Stem Cells Regulates the Notch Pathway

(2013) Jo Meagan Garner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ibrutinib and novel BTK inhibitors in clinical development

(2013) Akintunde Akinleye et al.   Journal of Hematology & Oncology

Interleukin-17 produced by tumor microenvironment promotes self-renewal of CD133+ cancer stem-like cells in ovarian cancer

(2013) T Xiang et al.   ONCOGENE

AXL induces epithelial-to-mesenchymal transition and regulates the function of breast cancer stem cells

(2013) M K Asiedu et al.   ONCOGENE

The NF-κB RelB Protein Is an Oncogenic Driver of Mesenchymal Glioma

(2013) Dong Whan Lee et al.   PLoS One

NF-κB Regulates Mesenchymal Transition for the Induction of Non-Small Cell Lung Cancer Initiating Cells

(2013) Manish Kumar et al.   PLoS One

NF-κB non-cell-autonomously regulates cancer stem cell populations in the basal-like breast cancer subtype

(2013) Mizuki Yamamoto et al.   Nature Communications

MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice

(2013) Jimmy L Zhao et al.   eLife

RANK Induces Epithelial-Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis

(2012) M. Palafox et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition Induced by TNF-  Requires NF- B-Mediated Transcriptional Upregulation of Twist1

(2012) C.-W. Li et al.   CANCER RESEARCH

Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies

(2012) Kian-Huat Lim et al.   IMMUNOLOGICAL REVIEWS

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Celebrating 25 years of NF-κB research

(2012) Sankar Ghosh et al.   IMMUNOLOGICAL REVIEWS

Regulation of cell death and autophagy by IKK and NF-κB: critical mechanisms in immune function and cancer

(2012) Albert S. Baldwin   IMMUNOLOGICAL REVIEWS

CXCL12/CXCR4 Protein Signaling Axis Induces Sonic Hedgehog Expression in Pancreatic Cancer Cells via Extracellular Regulated Kinase- and Akt Kinase-mediated Activation of Nuclear Factor κB

(2012) Ajay P. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β induces miR-182 to sustain NF-κB activation in glioma subsets

(2012) Libing Song et al.   JOURNAL OF CLINICAL INVESTIGATION

Autocrine CCL5 Signaling Promotes Invasion and Migration of CD133+Ovarian Cancer Stem-Like Cells via NF-κB-Mediated MMP-9 Upregulation

(2012) Haixia Long et al.   STEM CELLS

Noncanonical NF-κB Signaling Regulates Hematopoietic Stem Cell Self-Renewal and Microenvironment Interactions

(2012) Chen Zhao et al.   STEM CELLS

miR-290 Cluster Modulates Pluripotency by Repressing Canonical NF-κB Signaling

(2012) Patrick Lüningschrör et al.   STEM CELLS

IL-6 Controls Leukemic Multipotent Progenitor Cell Fate and Contributes to Chronic Myelogenous Leukemia Development

(2011) Damien Reynaud et al.   CANCER CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

NEMO-Binding Domain Peptide Inhibits Constitutive NF- B Activity and Reduces Tumor Burden in a Canine Model of Relapsed, Refractory Diffuse Large B-Cell Lymphoma

(2011) A. Gaurnier-Hausser et al.   CLINICAL CANCER RESEARCH

Regulation of Cancer Stem Cells by Cytokine Networks: Attacking Cancer's Inflammatory Roots

(2011) H. Korkaya et al.   CLINICAL CANCER RESEARCH

Pro-inflammatory gene expression in solid glioblastoma microenvironment and in hypoxic stem cells from human glioblastoma

(2011) Marco Tafani et al.   Journal of Neuroinflammation

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

Antitumor effect of dehydroxymethylepoxyquinomicin, a small molecule inhibitor of nuclear factor- B, on glioblastoma

(2011) T. Fukushima et al.   NEURO-ONCOLOGY

NF-κB suppresses ROS levels in BCR–ABL+ cells to prevent activation of JNK and cell death

(2011) S J Stein et al.   ONCOGENE

NF-κB inducing kinase (NIK) modulates melanoma tumorigenesis by regulating expression of pro-survival factors through the β-catenin pathway

(2011) Y M Thu et al.   ONCOGENE

Blockade of the NFκB pathway drives differentiating glioblastoma-initiating cells into senescence both in vitro and in vivo

(2011) L Nogueira et al.   ONCOGENE

Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion

(2011) D. Iliopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transdifferentiation of glioblastoma cells into vascular endothelial cells

(2011) Y. Soda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumour-initiating stem-like cells in human prostate cancer exhibit increased NF-κB signalling

(2011) Vinagolu K. Rajasekhar et al.   Nature Communications

Oncogenic EGFR Signaling Activates an mTORC2-NF- B Pathway That Promotes Chemotherapy Resistance

(2011) K. Tanaka et al.   Cancer Discovery

Response and Resistance to NF- B Inhibitors in Mouse Models of Lung Adenocarcinoma

(2011) W. Xue et al.   Cancer Discovery

PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB–Cytokine Network

(2011) Haoqiang Ying et al.   Cancer Discovery

Regulation of Inflammation by the NF-κB Pathway in Ovarian Cancer Stem Cells

(2010) Aliza L. Leizer et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Constitutive noncanonical NFκB signaling in pancreatic cancer cells

(2010) Catherine E. Wharry et al.   CANCER BIOLOGY & THERAPY

A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma

(2010) Ruihuan Chen et al.   CANCER CELL

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

(2010) Neta Erez et al.   CANCER CELL

Requirement of the NF-κB Subunit p65/RelA for K-Ras–Induced Lung Tumorigenesis

(2010) Daniela S. Bassères et al.   CANCER RESEARCH

The Canonical NF- B Pathway Governs Mammary Tumorigenesis in Transgenic Mice and Tumor Stem Cell Expansion

(2010) M. Liu et al.   CANCER RESEARCH

Anti-apoptotic effect of hyperglycemia can allow survival of potentially autoreactive T cells

(2010) P Ramakrishnan et al.   CELL DEATH AND DIFFERENTIATION

Perivascular Nitric Oxide Activates Notch Signaling and Promotes Stem-like Character in PDGF-Induced Glioma Cells

(2010) Nikki Charles et al.   Cell Stem Cell

TNFalpha up-regulates SLUG via the NF-kappaB/HIF1alpha axis, which imparts breast cancer cells with a stem cell-like phenotype

(2010) Gianluca Storci et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Conditional ablation of Ikkb inhibits melanoma tumor development in mice

(2010) Jinming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer

(2010) Daniel Schramek et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

NFKBIADeletion in Glioblastomas

(2010) Markus Bredel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells

(2009) M Murohashi et al.   BRITISH JOURNAL OF CANCER

Stabilization of Snail by NF-κB Is Required for Inflammation-Induced Cell Migration and Invasion

(2009) Yadi Wu et al.   CANCER CELL

RelB Enhances Prostate Cancer Growth: Implications for the Role of the Nuclear Factor- B Alternative Pathway in Tumorigenicity

(2009) Y. Xu et al.   CANCER RESEARCH

An Epigenetic Switch Involving NF-κB, Lin28, Let-7 MicroRNA, and IL6 Links Inflammation to Cell Transformation

(2009) Dimitrios Iliopoulos et al.   CELL

Requirement for NF-κB signalling in a mouse model of lung adenocarcinoma

(2009) Etienne Meylan et al.   NATURE

The canonical NF-κB pathway is required for formation of luminal mammary neoplasias and is activated in the mammary progenitor population

(2009) M A C Pratt et al.   ONCOGENE

Her2 activates NF-κB and induces invasion through the canonical pathway involving IKKα

(2009) E C Merkhofer et al.   ONCOGENE

Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP

(2009) Yifeng Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

Stem-Like Ovarian Cancer Cells Can Serve as Tumor Vascular Progenitors

(2009) Ayesha B. Alvero et al.   STEM CELLS

Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data

(2008) D. C. Hassane et al.   BLOOD

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

IKK/NF-κB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis

(2008) Nadine Bakkar et al.   JOURNAL OF CELL BIOLOGY

NF-κB and epithelial to mesenchymal transition of cancer

(2008) Chengyin Min et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions

(2008) Richard Birnie et al.   GENOME BIOLOGY