Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines

The Intracellular Destiny of the Protein Corona: A Study on its Cellular Internalization and Evolution

(2016) Filippo Bertoli et al.   ACS Nano

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

Functionalized Silica Nanoparticles As an Alternative Platform for Targeted Drug-Delivery of Water Insoluble Drugs

(2016) Luciane França de Oliveira et al.   LANGMUIR

The nanoparticle biomolecule corona: lessons learned – challenge accepted?

(2015) D. Docter et al.   CHEMICAL SOCIETY REVIEWS

Hollow mesoporous silica nanoparticles for tumor vasculature targeting and PET image-guided drug delivery

(2015) Rubel Chakravarty et al.   Nanomedicine

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

(2015) Hui-Wen Chiu et al.   Nanoscale

An effective strategy of magnetic stem cell delivery for spinal cord injury therapy

(2015) Dmitry Tukmachev et al.   Nanoscale

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Advances in targeted therapies for hepatocellular carcinoma in the genomic era

(2015) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

Opportunities and challenges of radiotherapy for treating cancer

(2015) Dörthe Schaue et al.   Nature Reviews Clinical Oncology

A holistic approach to targeting disease with polymeric nanoparticles

(2015) Christopher J. Cheng et al.   NATURE REVIEWS DRUG DISCOVERY

Immunological landscape and immunotherapy of hepatocellular carcinoma

(2015) Jesús Prieto et al.   Nature Reviews Gastroenterology & Hepatology

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Beyond Bar and Line Graphs: Time for a New Data Presentation Paradigm

(2015) Tracey L. Weissgerber et al.   PLOS BIOLOGY

Protective Effects of Bovine Serum Albumin on Superparamagnetic Iron Oxide Nanoparticles Evaluated in the Nematode Caenorhabditis elegans

(2015) Laura Gonzalez-Moragas et al.   ACS Biomaterials-Science & Engineering

Protective Effects of Bovine Serum Albumin on Superparamagnetic Iron Oxide Nanoparticles Evaluated in the Nematode Caenorhabditis elegans

(2015) Laura Gonzalez-Moragas et al.   ACS Biomaterials Science & Engineering

Amine-modified hyaluronic acid-functionalized porous silicon nanoparticles for targeting breast cancer tumors

(2014) Patrick V. Almeida et al.   Nanoscale

A general mechanism for intracellular toxicity of metal-containing nanoparticles

(2014) Stefania Sabella et al.   Nanoscale

Functionalized polystyrene nanoparticles as a platform for studying bio–nano interactions

(2014) Cornelia Loos et al.   Beilstein Journal of Nanotechnology

The protein corona protects against size- and dose-dependent toxicity of amorphous silica nanoparticles

(2014) Dominic Docter et al.   Beilstein Journal of Nanotechnology

Facing the Truth about Nanotechnology in Drug Delivery

(2013) Kinam Park   ACS Nano

Amino-functionalized nanoparticles as inhibitors of mTOR and inducers of cell cycle arrest in leukemia cells

(2013) Cornelia Loos et al.   BIOMATERIALS

It Takes a CAD to Kill a Tumor Cell with a LMP

(2013) Erich Gulbins et al.   CANCER CELL

Transformation-Associated Changes in Sphingolipid Metabolism Sensitize Cells to Lysosomal Cell Death Induced by Inhibitors of Acid Sphingomyelinase

(2013) Nikolaj H.T. Petersen et al.   CANCER CELL

Targeting the mTOR pathway in hepatocellular carcinoma: Current state and future trends

(2013) Matthias S. Matter et al.   JOURNAL OF HEPATOLOGY

Killing from the inside

(2013) Paul Saftig et al.   NATURE

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Comparison of polystyrene nanoparticles and UV-inactivated antigen-displaying adenovirus for vaccine delivery in mice

(2013) Lena Johrden et al.   Virology Journal

Probing of the Assembly Structure and Dynamics within Nanoparticles during Interaction with Blood Proteins

(2012) Yuanpei Li et al.   ACS Nano

Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery

(2012) Fangqiong Tang et al.   ADVANCED MATERIALS

Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival

(2012) Alejo Efeyan et al.   NATURE

Cancer-associated lysosomal changes: friends or foes?

(2012) T Kallunki et al.   ONCOGENE

Targeting Strategies for Multifunctional Nanoparticles in Cancer Imaging and Therapy

(2012) Mi Kyung Yu et al.   Theranostics

Amino-Functionalized Polystyrene Nanoparticles Activate the NLRP3 Inflammasome in Human Macrophages

(2011) Oleg Lunov et al.   ACS Nano

Differential Uptake of Functionalized Polystyrene Nanoparticles by Human Macrophages and a Monocytic Cell Line

(2011) Oleg Lunov et al.   ACS Nano

The role of moderate static magnetic fields on biomineralization of osteoblasts on sulfonated polystyrene films

(2011) Xiaolan Ba et al.   BIOMATERIALS

Induction of ROS, mitochondrial damage and autophagy in lung epithelial cancer cells by iron oxide nanoparticles

(2011) Mohd Imran Khan et al.   BIOMATERIALS

Inert 50-nm Polystyrene Nanoparticles That Modify Pulmonary Dendritic Cell Function and Inhibit Allergic Airway Inflammation

(2011) C. L. Hardy et al.   JOURNAL OF IMMUNOLOGY

Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes

(2010) Oleg Lunov et al.   BIOMATERIALS

The effect of carboxydextran-coated superparamagnetic iron oxide nanoparticles on c-Jun N-terminal kinase-mediated apoptosis in human macrophages

(2010) Oleg Lunov et al.   BIOMATERIALS

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?

(2010) Alaaldin M. Alkilany et al.   JOURNAL OF NANOPARTICLE RESEARCH

An Integrated Approach to the Study of the Interaction between Proteins and Nanoparticles

(2010) Francesco Turci et al.   LANGMUIR

Targeted nanoagents for the detection of cancers

(2010) Jason R. McCarthy et al.   Molecular Oncology

Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications

(2010) Jinjun Shi et al.   NANO LETTERS

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mesoporous Silica Nanoparticles for Intracellular Controlled Drug Delivery

(2010) Juan L. Vivero-Escoto et al.   Small

Statistical aspects of design and validation of microtitre-plate-based linear and non-linear parallelin vitrobioassays

(2009) Hanne Zimmermann et al.   Biotechnology Journal

Mammalian target of rapamycin inhibitors and their potential role in therapy in leukaemia and other haematological malignancies

(2009) David T. Teachey et al.   BRITISH JOURNAL OF HAEMATOLOGY

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

Nanoparticle-based targeted drug delivery

(2009) Rajesh Singh et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Biodegradability of Plastics

(2009) Yutaka Tokiwa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Accuracy and precision in quantitative fluorescence microscopy

(2009) Jennifer C. Waters   JOURNAL OF CELL BIOLOGY

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Biodegradable luminescent porous silicon nanoparticles for in vivo applications

(2009) Ji-Ho Park et al.   NATURE MATERIALS

A quantitative fluorescence study of protein monolayer formation on colloidal nanoparticles

(2009) Carlheinz Röcker et al.   Nature Nanotechnology

Quantification and its Applications in Fluorescent Microscopy Imaging

(2009) Nicholas Hamilton   TRAFFIC

Amino Acids Activate mTOR Complex 1 via Ca2+/CaM Signaling to hVps34

(2008) Pawan Gulati et al.   Cell Metabolism

Role of mTOR in anticancer drug resistance: Perspectives for improved drug treatment

(2008) Bing-Hua Jiang et al.   DRUG RESISTANCE UPDATES

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

(2008) Augusto Villanueva et al.   GASTROENTEROLOGY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE