Regulatory gene mutation: a driving force behind group aStreptococcusstrain- and serotype-specific variation

A Naturally Occurring Single Amino Acid Replacement in Multiple Gene Regulator of Group A Streptococcus Significantly Increases Virulence

(2015) Misu Sanson et al.   AMERICAN JOURNAL OF PATHOLOGY

A Single Amino Acid Replacement in the Sensor Kinase LiaS Contributes to a Carrier Phenotype in Group A Streptococcus

(2015) Anthony R. Flores et al.   INFECTION AND IMMUNITY

The Majority of 9,729 Group A Streptococcus Strains Causing Disease Secrete SpeB Cysteine Protease: Pathogenesis Implications

(2015) Randall J. Olsen et al.   INFECTION AND IMMUNITY

Phosphorylation Events in the Multiple Gene Regulator of Group A Streptococcus Significantly Influence Global Gene Expression and Virulence

(2015) Misu Sanson et al.   INFECTION AND IMMUNITY

A Truncation in the Regulator RocA Underlies Heightened Capsule Expression in Serotype M3 Group A Streptococci

(2015) N. N. Lynskey et al.   INFECTION AND IMMUNITY

Reply to “A Truncation in the Regulator RocA Underlies Heightened Capsule Expression in Serotype M3 Group A Streptococci”

(2015) Eric W. Miller et al.   INFECTION AND IMMUNITY

The FasX Small Regulatory RNA Negatively Regulates the Expression of Two Fibronectin-Binding Proteins in Group A Streptococcus

(2015) Jessica L. Danger et al.   JOURNAL OF BACTERIOLOGY

A molecular trigger for intercontinental epidemics of group A Streptococcus

(2015) Luchang Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulatory rewiring confers serotype-specific hyper-virulence in the human pathogen group AStreptococcus

(2015) Eric W. Miller et al.   MOLECULAR MICROBIOLOGY

The small regulatory RNA FasX enhances group AStreptococcusvirulence and inhibits pilus expression via serotype-specific targets

(2015) Jessica L. Danger et al.   MOLECULAR MICROBIOLOGY

A naturally occurring prfA truncation in a Listeria monocytogenes field strain contributes to reduced replication and cell-to-cell spread

(2015) Sebastian Rupp et al.   VETERINARY MICROBIOLOGY

Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung

(2015) Julio Diaz Caballero et al.   mBio

Consequences of the variability of the CovRS and RopB regulators among Streptococcus pyogenes causing human infections

(2015) Ana Friães et al.   Scientific Reports

Neutrophils Select Hypervirulent CovRS Mutants of M1T1 Group A Streptococcus during Subcutaneous Infection of Mice

(2014) Jinquan Li et al.   INFECTION AND IMMUNITY

Natural Disruption of Two Regulatory Networks in Serotype M3 Group A Streptococcus Isolates Contributes to the Virulence Factor Profile of This Hypervirulent Serotype

(2014) Tram N. Cao et al.   INFECTION AND IMMUNITY

Rheumatic Fever, Autoimmunity, and Molecular Mimicry: The Streptococcal Connection

(2014) Madeleine W. Cunningham   INTERNATIONAL REVIEWS OF IMMUNOLOGY

The Human Antimicrobial Peptide LL-37 Binds Directly to CsrS, a Sensor Histidine Kinase of Group AStreptococcus, to Activate Expression of Virulence Factors

(2014) Jorge J. Velarde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A liaR Deletion Restores Susceptibility to Daptomycin and Antimicrobial Peptides in Multidrug-Resistant Enterococcus faecalis

(2014) Jinnethe Reyes et al.   JOURNAL OF INFECTIOUS DISEASES

The Bacterial Phosphoenolpyruvate:Carbohydrate Phosphotransferase System: Regulation by Protein Phosphorylation and Phosphorylation-Dependent Protein-Protein Interactions

(2014) Josef Deutscher et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Evolution of hypervirulence by a MRSA clone through acquisition of a transposable element

(2014) Meredith A. Benson et al.   MOLECULAR MICROBIOLOGY

RNA-mediated regulation in Gram-positive pathogens: an overview punctuated with examples from the group AStreptococcus

(2014) Eric W. Miller et al.   MOLECULAR MICROBIOLOGY

Crystal structure ofBacillus anthracisvirulence regulator AtxA and effects of phosphorylated histidines on multimerization and activity

(2014) Troy G. Hammerstrom et al.   MOLECULAR MICROBIOLOGY

Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence

(2014) Jeffrey A. Mayfield et al.   PLoS One

Comparison of Widely Used Listeria monocytogenes Strains EGD, 10403S, and EGD-e Highlights Genomic Differences Underlying Variations in Pathogenicity

(2014) C. Becavin et al.   mBio

Natural Variation in the Promoter of the Gene Encoding the Mga Regulator Alters Host-Pathogen Interactions in Group A Streptococcus Carrier Strains

(2013) Anthony R. Flores et al.   INFECTION AND IMMUNITY

Evolution of community- and healthcare-associated methicillin-resistant Staphylococcus aureus

(2013) Anne-Catrin Uhlemann et al.   INFECTION GENETICS AND EVOLUTION

The two-component response regulator LiaR regulates cell wall stress responses, pili expression and virulence in group B Streptococcus

(2013) D. C. Klinzing et al.   MICROBIOLOGY-SGM

PTS phosphorylation of Mga modulates regulon expression and virulence in the group A streptococcus

(2013) Elise R. Hondorp et al.   MOLECULAR MICROBIOLOGY

Inactivation of the CovR/S Virulence Regulator Impairs Infection in an Improved Murine Model of Streptococcus pyogenes Naso-Pharyngeal Infection

(2013) Faraz M. Alam et al.   PLoS One

RocA Truncation Underpins Hyper-Encapsulation, Carriage Longevity and Transmissibility of Serotype M18 Group A Streptococci

(2013) Nicola N. Lynskey et al.   PLoS Pathogens

RivR Is a Negative Regulator of Virulence Factor Expression in Group A Streptococcus

(2012) Jeanette Treviño et al.   INFECTION AND IMMUNITY

The small regulatory RNA FasX controls pilus expression and adherence in the human bacterial pathogen group AStreptococcus

(2012) Zhuyun Liu et al.   MOLECULAR MICROBIOLOGY

Evolutionary dynamics of Staphylococcus aureus during progression from carriage to disease

(2012) B. C. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intraspecies Variation in the Emergence of Hyperinfectious Bacterial Strains in Nature

(2012) Douglas M. Heithoff et al.   PLoS Pathogens

Phage-Like Streptococcus pyogenes Chromosomal Islands (SpyCI) and Mutator Phenotypes: Control by Growth State and Rescue by a SpyCI-Encoded Promoter

(2012) Julie Scott et al.   Frontiers in Microbiology

Cysteine proteinase SpeB from Streptococcus pyogenes – a potent modifier of immunologically important host and bacterial proteins

(2011) Daniel C. Nelson et al.   BIOLOGICAL CHEMISTRY

Role of the Accessory Gene Regulatoragrin Community-Associated Methicillin-Resistant Staphylococcus aureus Pathogenesis

(2011) Gordon Y. C. Cheung et al.   INFECTION AND IMMUNITY

From transcription to activation: how group A streptococcus, the flesh-eating pathogen, regulates SpeB cysteine protease production

(2011) Ronan K. Carroll et al.   MOLECULAR MICROBIOLOGY

Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes

(2011) Tami D Lieberman et al.   NATURE GENETICS

Evolutionary dynamics of bacteria in a human host environment

(2011) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct signatures of diversifying selection revealed by genome analysis of respiratory tract and invasive bacterial populations

(2011) P. R. Shea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid Pneumococcal Evolution in Response to Clinical Interventions

(2011) N. J. Croucher et al.   SCIENCE

Genetic Switch to Hypervirulence Reduces Colonization Phenotypes of the Globally Disseminated Group AStreptococcusM1T1 Clone

(2010) Andrew Hollands et al.   JOURNAL OF INFECTIOUS DISEASES

The group A Streptococcus small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the ska mRNA transcript

(2010) Esmeralda Ramirez-Peña et al.   MOLECULAR MICROBIOLOGY

Prevalence of Streptococcal Pharyngitis and Streptococcal Carriage in Children: A Meta-analysis

(2010) N. Shaikh et al.   PEDIATRICS

Molecular complexity of successive bacterial epidemics deconvoluted by comparative pathogenomics

(2010) S. B. Beres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Frequent Mutations in Negative Regulators of Multiple Virulence Genes in Group A Streptococcal Toxic Shock Syndrome Isolates

(2010) Tadayoshi Ikebe et al.   PLoS Pathogens

Molecular Pathogenesis of Necrotizing Fasciitis

(2009) Randall J. Olsen et al.   Annual Review of Pathology-Mechanisms of Disease

CovS Simultaneously Activates and Inhibits the CovR-Mediated Repression of Distinct Subsets of Group A Streptococcus Virulence Factor-Encoding Genes

(2009) J. Trevino et al.   INFECTION AND IMMUNITY

A Genome-Wide Analysis of Small Regulatory RNAs in the Human Pathogen Group A Streptococcus

(2009) Nataly Perez et al.   PLoS One

The IL-8 Protease SpyCEP/ScpC of Group A Streptococcus Promotes Resistance to Neutrophil Killing

(2008) Annelies S. Zinkernagel et al.   Cell Host & Microbe

A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus

(2008) S. A. Shelburne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of group A Streptococcus virulence by a human antimicrobial peptide

(2008) I. Gryllos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Whole-genome comparison of disease and carriage strains provides insights into virulence evolution in Neisseria meningitidis

(2008) C. Schoen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The clinical consequences of strain diversity in Mycobacterium tuberculosis

(2008) Mark P. Nicol et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE