Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

(2021) Rachael E. Workman et al.   CELL

Type II toxin-antitoxin systems: evolution and revolutions

(2020) N. Fraikin et al.   JOURNAL OF BACTERIOLOGY

A Primary Physiological Role of Toxin/Antitoxin Systems Is Phage Inhibition

(2020) Sooyeon Song et al.   Frontiers in Microbiology

DNA targeting by subtype I-D CRISPR–Cas shows type I and type III features

(2020) Jinzhong Lin et al.   NUCLEIC ACIDS RESEARCH

Non-specific degradation of transcripts promotes plasmid clearance during type III-A CRISPR–Cas immunity

(2019) Jakob T. Rostøl et al.   Nature Microbiology

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

(2019) Alexander J. Meeske et al.   NATURE

Primed adaptation tolerates extensive structural and size variations of the CRISPR RNA guide in Haloarcula hispanica

(2019) Luyao Gong et al.   NUCLEIC ACIDS RESEARCH

Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence

(2019) Hannah K. Ratner et al.   MOLECULAR CELL

Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire

(2019) Eugene V. Koonin et al.   NATURE REVIEWS GENETICS

Translational coupling via termination-reinitiation in archaea and bacteria

(2019) Madeleine Huber et al.   Nature Communications

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

The Biology of CRISPR-Cas: Backward and Forward

(2018) Frank Hille et al.   CELL

Comparative genomics and evolution of trans-activating RNAs in Class 2 CRISPR-Cas systems

(2018) Guilhem Faure et al.   RNA Biology

Toxins targeting transfer RNAs: Translation inhibition by bacterial toxin-antitoxin systems

(2018) Lauren R. Walling et al.   Wiley Interdisciplinary Reviews-RNA

IntaRNA 2.0: enhanced and customizable prediction of RNA–RNA interactions

(2017) Martin Mann et al.   NUCLEIC ACIDS RESEARCH

Disentangling the effects of selection and loss bias on gene dynamics

(2017) Jaime Iranzo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coupling immunity and programmed cell suicide in prokaryotes: Life-or-death choices

(2016) Eugene V. Koonin et al.   BIOESSAYS

Toxin-antitoxin systems in bacterial growth arrest and persistence

(2016) Rebecca Page et al.   Nature Chemical Biology

DNA motifs determining the accuracy of repeat duplication during CRISPR adaptation inHaloarcula hispanica

(2016) Rui Wang et al.   NUCLEIC ACIDS RESEARCH

Widespread formation of alternative 3′ UTR isoforms via transcription termination in archaea

(2016) Daniel Dar et al.   Nature Microbiology

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile

(2015) Pierre Boudry et al.   mBio

A Novel DNA-Binding Protein, PhaR, Plays a Central Role in the Regulation of Polyhydroxyalkanoate Accumulation and Granule Formation in the Haloarchaeon Haloferax mediterranei

(2014) Shuangfeng Cai et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli

(2014) Hongtu Zhao et al.   NATURE

Haloarcula hispanica CRISPR authenticates PAM of a target sequence to prime discriminative adaptation

(2014) M. Li et al.   NUCLEIC ACIDS RESEARCH

Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression

(2014) Michelle L. Luo et al.   NUCLEIC ACIDS RESEARCH

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process

(2013) Ming Li et al.   NUCLEIC ACIDS RESEARCH

Cytotoxic Chromosomal Targeting by CRISPR/Cas Systems Can Reshape Bacterial Genomes and Expel or Remodel Pathogenicity Islands

(2013) Reuben B. Vercoe et al.   PLoS Genetics

Dealing with the Evolutionary Downside of CRISPR Immunity: Bacteria and Beneficial Plasmids

(2013) Wenyan Jiang et al.   PLoS Genetics

CRISPR Interference Can Prevent Natural Transformation and Virulence Acquisition during In Vivo Bacterial Infection

(2012) David Bikard et al.   Cell Host & Microbe

RNA-guided genetic silencing systems in bacteria and archaea

(2012) Blake Wiedenheft et al.   NATURE

ViennaRNA Package 2.0

(2011) Ronny Lorenz et al.   Algorithms for Molecular Biology

Development of pyrF-based gene knockout systems for genome-wide manipulation of the archaea Haloferax mediterranei and Haloarcula hispanica

(2011) Hailong Liu et al.   Journal of Genetics and Genomics

HMMER web server: interactive sequence similarity searching

(2011) R. D. Finn et al.   NUCLEIC ACIDS RESEARCH

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

(2011) E. Semenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved Strains and Plasmid Vectors for Conditional Overexpression of His-Tagged Proteins in Haloferax volcanii

(2010) T. Allers et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Self-targeting by CRISPR: gene regulation or autoimmunity?

(2010) Adi Stern et al.   TRENDS IN GENETICS

A novel mechanism for translation initiation operates in haloarchaea

(2009) Oliver Hering et al.   MOLECULAR MICROBIOLOGY

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

(2008) S. J. J. Brouns et al.   SCIENCE