Structure of a type IV CRISPR-Cas ribonucleoprotein complex

Cryo-EM structure of the RNA-guided ribonuclease Cas12g

(2021) Zhuang Li et al.   Nature Chemical Biology

A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity

(2020) Alexander J. Meeske et al.   SCIENCE

Structures of the Cmr-β Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas

(2020) Nicholas Sofos et al.   MOLECULAR CELL

Mechanisms for target recognition and cleavage by the Cas12i RNA-guided endonuclease

(2020) Heng Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the miniature type V-F CRISPR-Cas effector enzyme

(2020) Satoru N. Takeda et al.   MOLECULAR CELL

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

(2019) Ian M. Slaymaker et al.   Cell Reports

CasX enzymes comprise a distinct family of RNA-guided genome editors

(2019) Jun-Jie Liu et al.   NATURE

Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry

(2019) MaryClare F. Rollins et al.   MOLECULAR CELL

Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration

(2019) Sanne E. Klompe et al.   NATURE

CRISPR–Cas in mobile genetic elements: counter-defence and beyond

(2019) Guilhem Faure et al.   NATURE REVIEWS MICROBIOLOGY

Cryo-EM structures reveal coordinated domain motions that govern DNA cleavage by Cas9

(2019) Xing Zhu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis of Type IV CRISPR RNA biogenesis by a Cas6 endoribonuclease

(2019) Hannah N. Taylor et al.   RNA Biology

Structural basis of DNA targeting by a transposon-encoded CRISPR–Cas system

(2019) Tyler S. Halpin-Healy et al.   NATURE

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Type IV CRISPR–Cas systems are highly diverse and involved in competition between plasmids

(2019) Rafael Pinilla-Redondo et al.   NUCLEIC ACIDS RESEARCH

The Biology of CRISPR-Cas: Backward and Forward

(2018) Frank Hille et al.   CELL

Cas13d Is a Compact RNA-Targeting Type VI CRISPR Effector Positively Modulated by a WYL-Domain-Containing Accessory Protein

(2018) Winston X. Yan et al.   MOLECULAR CELL

Structure basis for RNA-guided DNA degradation by Cascade and Cas3

(2018) Yibei Xiao et al.   SCIENCE

Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference

(2018) Lilan You et al.   CELL

Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity

(2018) Ning Jia et al.   MOLECULAR CELL

Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum

(2018) Ahsen Özcan et al.   Nature Microbiology

Structure of the Cpf1 endonuclease R-loop complex after target DNA cleavage

(2017) Stefano Stella et al.   NATURE

DNA Targeting by a Minimal CRISPR RNA-Guided Cascade

(2016) Megan L. Hochstrasser et al.   MOLECULAR CELL

Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage

(2016) F. Jiang et al.   SCIENCE

Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning

(2015) D. W. Taylor et al.   SCIENCE

RNA Targeting by the Type III-A CRISPR-Cas Csm Complex of Thermus thermophilus

(2014) Raymond H.J. Staals et al.   MOLECULAR CELL

Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target

(2014) S. Mulepati et al.   SCIENCE

Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli

(2014) R. N. Jackson et al.   SCIENCE

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

(2014) M. Jinek et al.   SCIENCE