A Systematic Review of the Biological Effects of Cordycepin

Cordycepin exhibits a suppressive effect on T cells through inhibiting TCR signaling cascade in CFA-induced inflammation mice model

(2020) Xiaoli Wang et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Cordycepin Resensitizes T24R2 Cisplatin-Resistant Human Bladder Cancer Cells to Cisplatin by Inactivating Ets-1 Dependent MDR1 Transcription

(2020) Sang-Seok Oh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cordycepin inhibits cancer cell proliferation and angiogenesis through a DEK interaction via ERK signaling in cholangiocarcinoma

(2020) Tesi Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ERK/MAPK signalling pathway and tumorigenesis (Review)

(2020) Yan‑Jun Guo et al.   Experimental and Therapeutic Medicine

The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency

(2020) Chie-Hong Wang et al.   Scientific Reports

Microtubule-targeting agents and their impact on cancer treatment

(2020) Vladimír Čermák et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Chemical perturbations reveal that RUVBL2 regulates the circadian phase in mammals

(2020) Dapeng Ju et al.   Science Translational Medicine

Lost in Translation: Physiological Roles of Stored mRNAs in Seed Germination

(2020) Naoto Sano et al.   Plants-Basel

Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?

(2020) Hannah J. Smith et al.   DEVELOPMENTAL CELL

Cordycepin protects against acute pancreatitis by modulating NF-κB and NLRP3 inflammasome activation via AMPK

(2020) Jing Yang et al.   LIFE SCIENCES

Cordycepin Inhibits Human Gestational Choriocarcinoma Cell Growth by Disrupting Centrosome Homeostasis

(2020) Chia-Yih Wang et al.   Drug Design Development and Therapy

Cordycepin induces apoptosis in human tongue cancer cells in vitro and has antitumor effects in vivo

(2020) Qingwei Zheng et al.   ARCHIVES OF ORAL BIOLOGY

Cordycepin-loaded Nanoparticles from Cassava Starch Promote the Proliferation of Submandibular Gland Cells and Inhibit the Growth of Oral Squamous Carcinoma Cells

(2020) Palakorn Kaokaen et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Cordycepin enhances the chemosensitivity of esophageal cancer cells to cisplatin by inducing the activation of AMPK and suppressing the AKT signaling pathway

(2020) Ying Gao et al.   Cell Death & Disease

Combination of Cordycepin and Apatinib Synergistically Inhibits NSCLC Cells by Down-Regulating VEGF/PI3K/Akt Signaling Pathway

(2020) Xiaozhong Liao et al.   Frontiers in Oncology

Improvement of the multi-performance biocharacteristics of cordycepin using BiloNiosome-core/chitosan-shell hybrid nanocarriers

(2020) Warut Kengkittipat et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Cordycepin attenuates high-fat diet-induced non-alcoholic fatty liver disease via down-regulation of lipid metabolism and inflammatory responses

(2020) Xiaobao Gong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Screening Five Qi-Tonifying Herbs on M2 Phenotype Macrophages

(2019) Yi-Xin Jiang et al.   Evidence-based Complementary and Alternative Medicine

Cordycepin Suppresses Endothelial Cell Proliferation, Migration, Angiogenesis, and Tumor Growth by Regulating Focal Adhesion Kinase and p53

(2019) Yi-Ting Lin et al.   Cancers

Ethylene carbodiimide-fixed donor splenocytes combined with cordycepin induce long-term protection to mice cardiac allografts

(2019) Lai Xingqiang et al.   TRANSPLANT IMMUNOLOGY

Tricarboxylic acid cycle metabolites in the control of macrophage activation and effector phenotypes

(2019) Jordan T. Noe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cordycepin (3′-deoxyadenosine) and pentostatin (deoxycoformycin) against Trypanosoma cruzi

(2019) Guilherme M. do Carmo et al.   EXPERIMENTAL PARASITOLOGY

Fabrication of 3D calcium‐alginate scaffolds for human glioblastoma modeling and anticancer drug response evaluation

(2019) Nipha Chaicharoenaudomrung et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cordycepin suppresses cell proliferation and migration by targeting CLEC2 in human gastric cancer cells via Akt signaling pathway

(2019) Ying Wang et al.   LIFE SCIENCES

Cordycepin mitigates MPTP-induced Parkinson's disease through inhibiting TLR/NF-κB signaling pathway

(2019) Chunyan Cheng et al.   LIFE SCIENCES

Cordyceps militaris Improves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway

(2019) Tingli Sun et al.   Oxidative Medicine and Cellular Longevity

Cordycepin‐induced unfolded protein response‐dependent cell death, and AKT/MAPK‐mediated drug resistance in mouse testicular tumor cells

(2019) Ming‐Min Chang et al.   Cancer Medicine

The cordycepin derivative IMM-H007 improves endothelial dysfunction by suppressing vascular inflammation and promoting AMPK-dependent eNOS activation in high-fat diet-fed ApoE knockout mice

(2019) Min-jie Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuroprotection of cordycepin in NMDA-induced excitotoxicity by modulating adenosine A1 receptors

(2019) Zhong-Si-Wei Dong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The protective effect of Cordycepin on diabetic nephropathy through autophagy induction in vivo and in vitro

(2019) Tao Cao et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Cordycepin ameliorates cardiac hypertrophy via activating the AMPKα pathway

(2019) Hui-Bo Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Cordycepin improves behavioral‐LTP and dendritic structure in hippocampal CA1 area of rats

(2019) Yuan‐Yuan Han et al.   JOURNAL OF NEUROCHEMISTRY

In vitro nociceptor neuroplasticity associated with in vivo opioid-induced hyperalgesia

(2019) Eugen V. Khomula et al.   JOURNAL OF NEUROSCIENCE

Cordycepin regulates body weight by inhibiting lipid droplet formation, promoting lipolysis and recruiting beige adipocytes

(2019) Hongyue Xu et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Cordycepin Inhibits Drug-resistance Non-small Cell Lung Cancer Progression by Activating AMPK Signaling Pathway

(2019) Chunli Wei et al.   PHARMACOLOGICAL RESEARCH

Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents

(2019) Ziwen Wang et al.   Nature Communications

Role and Therapeutic Targeting of the PI3K/Akt/mTOR Signaling Pathway in Skin Cancer: A Review of Current Status and Future Trends on Natural and Synthetic Agents Therapy

(2019) Chamcheu et al.   Cells

Coupled biosynthesis of cordycepin and pentostatin in Cordyceps militaris: implications for fungal biology and medicinal natural products

(2019) Peter A. D. Wellham et al.   Annals of Translational Medicine

Cordycepin alleviates hepatic lipid accumulation by inducing protective autophagy via PKA/mTOR pathway

(2019) Tianjiao Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A natural cordycepin/chitosan complex hydrogel with outstanding self-healable and wound healing properties

(2019) Ruru Song et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cordycepin induces apoptosis in human bladder cancer T24 cells through ROS-dependent inhibition of the PI3K/Akt signaling pathway

(2019) Sung Ok Kim et al.   BioScience Trends

The Inhibitory Effect of Cordycepin on the Proliferation of MCF-7 Breast Cancer Cells, and its Mechanism: An Investigation Using Network Pharmacology-Based Analysis

(2019) Lee et al.   Biomolecules

Cordycepin (3′-deoxyadenosine) promotes remyelination via suppression of neuroinflammation in a cuprizone-induced mouse model of demyelination

(2019) Yue Jia et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4

(2019) Zhongrong Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Cordycepin Enhances Radiosensitivity in Oral Squamous Carcinoma Cells by Inducing Autophagy and Apoptosis Through Cell Cycle Arrest

(2019) Ho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin

(2019) Jong Bong Lee et al.   Scientific Reports

Cordycepin Attenuates IFN-γ-Induced Macrophage IP-10 and Mig Expressions by Inhibiting STAT1 Activity in CFA-Induced Inflammation Mice Model

(2019) Rirong Yang et al.   INFLAMMATION

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

(2019) Fabian Hulpia et al.   Nature Communications

The inhibitory effect of Cordycepin on the proliferation of cisplatin-resistant A549 lung cancer cells

(2018) Seong Hyeok Cho et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cordycepin rescues lidocaine-induced neurotoxicity in dorsal root ganglion by interacting with inflammatory signaling pathway MMP3

(2018) Hongli Kan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress

(2018) Jiaji Lei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cordycepin alleviates lipopolysaccharide-induced acute lung injury via Nrf2/HO-1 pathway

(2018) Rui Qing et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Neuroprotective effects of cordycepin inhibit Aβ-induced apoptosis in hippocampal neurons

(2018) Hao Song et al.   NEUROTOXICOLOGY

Experimental and in silico analysis of cordycepin and its derivatives as endometrial cancer treatment

(2018) Pedro Fong et al.   ONCOLOGY RESEARCH

Phosphorylation of PI3K regulatory subunit p85 contributes to resistance against PI3K inhibitors in radioresistant head and neck cancer

(2018) Myung Woul Han et al.   ORAL ONCOLOGY

Effects of cordycepin on spontaneous alternation behavior and adenosine receptors expression in hippocampus

(2018) Zhi-Ping Cao et al.   PHYSIOLOGY & BEHAVIOR

TORC1 inhibition enhances immune function and reduces infections in the elderly

(2018) Joan B. Mannick et al.   Science Translational Medicine

Cordycepin induces apoptotic cell death of human brain cancer through the modulation of autophagy

(2018) Nipha Chaicharoenaudomrung et al.   TOXICOLOGY IN VITRO

β-catenin contributes to cordycepin-induced MGMT inhibition and reduction of temozolomide resistance in glioma cells by increasing intracellular reactive oxygen species

(2018) Yiming Bi et al.   CANCER LETTERS

Lentiviral Vector-Mediated SHC3 Silencing Exacerbates Oxidative Stress Injury in Nigral Dopamine Neurons by Regulating the PI3K-AKT-FoxO Signaling Pathway in Rats with Parkinson’s Disease

(2018) Jian Gong et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Cordycepin downregulates Cdk-2 to interfere with cell cycle and increases apoptosis by generating ROS in cervical cancer cells: in vitro and in silico study

(2018) Mousumi Tania et al.   CURRENT CANCER DRUG TARGETS

Cordycepin modulates body weight by reducing prolactin via an adenosine A1 receptor

(2018) Yuan Li et al.   CURRENT PHARMACEUTICAL DESIGN

Cordycepin activates autophagy through AMPK phosphorylation to reduce abnormalities in Machado-Joseph disease models

(2018) Adriana Marcelo et al.   HUMAN MOLECULAR GENETICS

The PI3K/AKT pathway in obesity and type 2 diabetes

(2018) Xingjun Huang et al.   International Journal of Biological Sciences

Cardiac fibrosis: new insights into the pathogenesis

(2018) Zhen-Guo Ma et al.   International Journal of Biological Sciences

Cordycepin induces apoptosis in human pancreatic cancer cells via the mitochondrial-mediated intrinsic pathway and suppresses tumor growth in vivo

(2018) Yu Zhang et al.   OncoTargets and Therapy

AKT phosphorylation sites of Ser473 and Thr308 regulate AKT degradation

(2018) Yingze Wei et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro

(2018) Su-Bin Yu et al.   Evidence-based Complementary and Alternative Medicine

Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats

(2018) Yanan An et al.   Lipids in Health and Disease

Cordycepin induces Bax‑dependent apoptosis in colorectal cancer cells

(2018) Shang‑Ze Li et al.   Molecular Medicine Reports

Cordycepin Augments the Chemosensitivity of Human Glioma Cells to Temozolomide by Activating AMPK and Inhibiting the AKT Signaling Pathway

(2018) Yiming Bi et al.   MOLECULAR PHARMACEUTICS

Mu-opioid Receptor (MOR) Biased Agonists Induce Biphasic Dose-dependent Hyperalgesia and Analgesia, and Hyperalgesic Priming in the Rat

(2018) Dionéia Araldi et al.   NEUROSCIENCE

TGF‐β: Master regulator of inflammation and fibrosis

(2018) Alastair G. Stewart et al.   RESPIROLOGY

Cordycepin promotes browning of white adipose tissue through an AMP-activated protein kinase (AMPK)-dependent pathway

(2018) Guihong Qi et al.   Acta Pharmaceutica Sinica B

Cordycepin sensitizes breast cancer cells toward irradiation through elevating ROS production involving Nrf2

(2018) Jiali Dong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Systemic Morphine Produces Dose-dependent Nociceptor-mediated Biphasic Changes in Nociceptive Threshold and Neuroplasticity

(2018) Luiz F. Ferrari et al.   NEUROSCIENCE

Cordycepin, isolated from medicinal fungus Cordyceps sinensis, enhances radiosensitivity of oral cancer associated with modulation of DNA damage repair

(2018) Nai-Wen Su et al.   FOOD AND CHEMICAL TOXICOLOGY

Cordycepin diminishes thymic stromal lymphopoietin-induced interleukin-13 production

(2017) Myoung-schook Yoou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cordycepin negatively modulates lipopolysaccharide-induced cytokine production by up-regulation of heme oxygenase-1

(2017) Rui Qing et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cordycepin induces apoptosis in SGC-7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS

(2017) Moussa Ide Nasser et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Protective Effect of Cordycepin on Experimental Testicular Ischemia/Reperfusion Injury in Rats

(2017) Mehmet Hanifi Okur et al.   JOURNAL OF INVESTIGATIVE SURGERY

Cordycepin inhibits migration of human glioblastoma cells by affecting lysosomal degradation and protein phosphatase activation

(2017) Dueng-Yuan Hueng et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Higher Anti-Liver Fibrosis Effect of Cordyceps militaris-Fermented Product Cultured with Deep Ocean Water via Inhibiting Proinflammatory Factors and Fibrosis-Related Factors Expressions

(2017) Yu-Ping Hung et al.   Marine Drugs

The Protective Effect of Cordycepin on D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Injury

(2017) Jin Li et al.   MEDIATORS OF INFLAMMATION

Cordycepin confers neuroprotection in mice models of intracerebral hemorrhage via suppressing NLRP3 inflammasome activation

(2017) Yijun Cheng et al.   METABOLIC BRAIN DISEASE

Treatment with 3′-deoxyadenosine and deoxycoformycin in mice infected by Trypanosoma cruzi and its side effect on purinergic enzymes

(2017) Guilherme M. do Carmo et al.   MICROBIAL PATHOGENESIS

Metronomic Cordycepin Therapy Prolongs Survival of Oral Cancer-Bearing Mice and Inhibits Epithelial-Mesenchymal Transition

(2017) Nai-Wen Su et al.   MOLECULES

A new ribonucleotide from Cordyceps militaris

(2017) Jinfeng Sun et al.   NATURAL PRODUCT RESEARCH

Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression

(2017) In-Hu Hwang et al.   PLoS One

Effects of N-Nitrosodiethylamine, a Potent Carcinogen, on Sexual Development, Gametogenesis, and Oocyte Maturation

(2017) Reshma Nair U et al.   Sexual Development

Cordycepin induces apoptosis in human bladder cancer cells via activation of A3 adenosine receptors

(2017) Hong-Li Cao et al.   TUMOR BIOLOGY

Cordycepin inhibits vascular adhesion molecule expression in TNF-α-stimulated vascular muscle cells

(2017) Li-Jie Yan et al.   Experimental and Therapeutic Medicine

Cordycepin induces apoptosis of human acute monocytic leukemia cells via downregulation of the ERK/Akt signaling pathway

(2017) Yue Wang et al.   Experimental and Therapeutic Medicine

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

(2017) Toby A. Dite et al.   Nature Communications

Cordycepin and a preparation from Cordyceps militaris inhibit malignant transformation and proliferation by decreasing EGFR and IL-17RA signaling in a murine oral cancer model

(2017) Peng-Yang Hsu et al.   Oncotarget

Cordycepin stimulates autophagy in macrophages and prevents atherosclerotic plaque formation in ApoE-/- mice

(2017) Xin Li et al.   Oncotarget

The inhibition of cordycepin on cancer stemness in TGF-beta induced chemo-resistant ovarian cancer cell

(2017) Chia-Woei Wang et al.   Oncotarget

Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinoma

(2017) Jong Cheon Joo et al.   Oncotarget

Cordycepin disrupts leukemia association with mesenchymal stromal cells and eliminates leukemia stem cell activity

(2017) Shu-Man Liang et al.   Scientific Reports

Cordycepin Affects Multiple Apoptotic Pathways to Mediate Hepatocellular Carcinoma Cell Death

(2016) Yulin Zhou et al.   Anti-Cancer Agents in Medicinal Chemistry

Cordycepin Suppresses Thymic Stromal Lymphopoietin Expression via Blocking Caspase-1 and Receptor-Interacting Protein 2 Signaling Pathways in Mast Cells

(2016) Myoung-schook Yoou et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Cordycepin protects PC12 cells against 6-hydroxydopamine induced neurotoxicity via its antioxidant properties

(2016) Opeyemi J. Olatunji et al.   BIOMEDICINE & PHARMACOTHERAPY

Cordycepin inhibits chondrocyte hypertrophy of mesenchymal stem cells through PI3K/Bapx1 and Notch signaling pathway

(2016) Zhen Cao et al.   BMB Reports

Cordycepin enhances Epstein–Barr virus lytic infection and Epstein–Barr virus-positive tumor treatment efficacy by doxorubicin

(2016) Yinping Du et al.   CANCER LETTERS

The Effects of Polyadenylation Status on MPFs During In Vitro Porcine Oocyte Maturation

(2016) Huiyu Liu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The anti-tumor effects of cordycepin-loaded liposomes on the growth of hepatoma 22 tumors in mice and human hepatoma BEL-7402 cells in culture

(2016) Peng-Kai Wu et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Cordycepin increases radiosensitivity in cervical cancer cells by overriding or prolonging radiation-induced G2/M arrest

(2016) Da Bin Seong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Apoptotic Effects of Cordycepin Through the Extrinsic Pathway and p38 MAPK Activation in Human Glioblastoma U87MG Cells

(2016) Ji-Sue Baik et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

The effects of cordycepin on the cell proliferation, migration and apoptosis in human lung cancer cell lines A549 and NCI-H460

(2016) Xiandong Tao et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships

(2016) András Zeke et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Regulation of Poly(A) Tail and Translation during the Somatic Cell Cycle

(2016) Jong-Eun Park et al.   MOLECULAR CELL

SDF1-CXCR4 Signaling Contributes to the Transition from Acute to Chronic Pain State

(2016) Fei Yang et al.   MOLECULAR NEUROBIOLOGY

Cordycepin Induces Apoptosis and Inhibits Proliferation of Human Lung Cancer Cell Line H1975 via Inhibiting the Phosphorylation of EGFR

(2016) Zheng Wang et al.   MOLECULES

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Gi-protein–coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming

(2016) Dioneia Araldi et al.   PAIN

The Gene Expression Status of the PI3K/AKT/mTOR Pathway in Gastric Cancer Tissues and Cell Lines

(2016) Ismael Riquelme et al.   PATHOLOGY & ONCOLOGY RESEARCH

Pain regulation by non-neuronal cells and inflammation

(2016) R.-R. Ji et al.   SCIENCE

Evolving Lessons on the Complex Role of AMPK in Normal Physiology and Cancer

(2016) Biplab Dasgupta et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

JNK and p38 mitogen-activated protein kinase pathways contribute to porcine epidemic diarrhea virus infection

(2016) Changhee Lee et al.   VIRUS RESEARCH

Transforming growth factor beta (TGF-β) isoforms in wound healing and fibrosis

(2016) Michael K. Lichtman et al.   WOUND REPAIR AND REGENERATION

Cordycepin induces apoptosis in human liver cancer HepG2 cells through extrinsic and intrinsic signaling pathways

(2016) Le-Wen Shao et al.   Oncology Letters

Cordycepin Prevents Bone Loss through Inhibiting Osteoclastogenesis by Scavenging ROS Generation

(2016) Ce Dou et al.   Nutrients

Photo-crosslinked HAMA hydrogel with cordycepin encapsulated chitosan microspheres for osteoarthritis treatment

(2016) Chen Xia et al.   Oncotarget

Cordycepin induces autophagy-mediated c-FLIPL degradation and leads to apoptosis in human non-small cell lung cancer cells

(2016) Xinghui Yu et al.   Oncotarget

Antimetastatic effects of cordycepin mediated by the inhibition of mitochondrial activity and estrogen-related receptor α in human ovarian carcinoma cells

(2016) Chia-Woei Wang et al.   Oncotarget

c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease

(2016) Ramon Yarza et al.   Frontiers in Pharmacology

Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc

(2016) Yan Li et al.   PeerJ

Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells

(2015) Kenta Imamura et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Preparation, spectroscopy and molecular modelling studies of the inclusion complex of cordycepin with cyclodextrins

(2015) Jian-Qiang Zhang et al.   CARBOHYDRATE RESEARCH

Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells

(2015) Yuanhong Liao et al.   CELL CYCLE

Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process

(2015) Xiaofeng Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cordycepin protected against the TNF-α-induced inhibition of osteogenic differentiation of human adipose-derived mesenchymal stem cells

(2015) Jianping Yang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

3’-Deoxyadenosine (Cordycepin) Produces a Rapid and Robust Antidepressant Effect via Enhancing Prefrontal AMPA Receptor Signaling Pathway

(2015) Bai Li et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT

(2015) Kyung-Jun Jang et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cordyceps militarisMushroom and Cordycepin Inhibit RANKL-Induced Osteoclast Differentiation

(2015) Jinhee Kim et al.   JOURNAL OF MEDICINAL FOOD

N6-(2-Hydroxyethyl)adenosine in the Medicinal Mushroom Cordyceps cicadae Attenuates Lipopolysaccharide-Stimulated Pro-inflammatory Responses by Suppressing TLR4-Mediated NF-κB Signaling Pathways

(2015) Meng-Ying Lu et al.   JOURNAL OF NATURAL PRODUCTS

Distinct Terminal and Cell Body Mechanisms in the Nociceptor Mediate Hyperalgesic Priming

(2015) Luiz F. Ferrari et al.   JOURNAL OF NEUROSCIENCE

Dose finding of 3′deoxyadenosine and deoxycoformycin for the treatment of Trypanosoma evansi infection: An effective and nontoxic dose

(2015) Luciana Dalla Rosa et al.   MICROBIAL PATHOGENESIS

Synergistic effect of HMGB1 knockdown and cordycepin in the K562 human chronic myeloid leukemia cell line

(2015) XI CHEN et al.   Molecular Medicine Reports

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Cordycepin from Cordyceps militaris prevents hyperglycemia in alloxan-induced diabetic mice

(2015) Li Ma et al.   NUTRITION RESEARCH

A direct protein kinase B-targeted anti inflammatory activity of cordycepin from artificially cultured fruit body of Cordyceps militaris

(2015) JaeYoul Cho et al.   Pharmacognosy Magazine

Apoptotic Effects of the Extracts ofCordyceps militarisvia Erk Phosphorylation in a Renal Cell Carcinoma Cell Line

(2015) Kazuhiro Yamamoto et al.   PHYTOTHERAPY RESEARCH

Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE(2)-M17 cells

(2015) YIFAN LI et al.   Oncology Letters

Cordycepin prevents oxidative stress-induced inhibition of osteogenesis

(2015) Feng Wang et al.   Oncotarget

Cordycepin (3’-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b

(2015) Pu Zhang et al.   Oncotarget

Cordycepin induced MA-10 mouse Leydig tumor cell apoptosis by regulating p38 MAPKs and PI3K/AKT signaling pathways

(2015) Bo-Syong Pan et al.   Scientific Reports

Detection and Differentiation of Threonine- and Tyrosine-Monophosphorylated Forms of ERK1/2 by Capillary Isoelectric Focusing-Immunoassay

(2015) Inga Kraus et al.   Scientific Reports

Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity

(2015) Pornanong Aramwit et al.   Nanoscale Research Letters

Effects of Cordycepin on the Microglia-Overactivation-Induced Impairments of Growth and Development of Hippocampal Cultured Neurons

(2015) Jie Peng et al.   PLoS One

Cordycepin Suppresses Integrin/FAK Signaling and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma

(2014) Wen-Ling Yao et al.   Anti-Cancer Agents in Medicinal Chemistry

Insulin inhibits AMPK activity and phosphorylates AMPK Ser485/491 through Akt in hepatocytes, myotubes and incubated rat skeletal muscle

(2014) Rudy J. Valentine et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway

(2014) Ying Chen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Involvement of autophagy in cordycepin-induced apoptosis in human prostate carcinoma LNCaP cells

(2014) Hye Hyeon Lee et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Antidepressant-Like Effects of Cordycepin in a Mice Model of Chronic Unpredictable Mild Stress

(2014) Zhang Tianzhu et al.   Evidence-based Complementary and Alternative Medicine

Cordycepin (3′-deoxyadenosine) Down-Regulates the Proinflammatory Cytokines in Inflammation-Induced Osteoporosis Model

(2014) Da-wei Zhang et al.   INFLAMMATION

The Effects of Cordycepin on Ovalbumin-Induced Allergic Inflammation by Strengthening Treg Response and Suppressing Th17 Responses in Ovalbumin-Sensitized Mice

(2014) Zhang Tianzhu et al.   INFLAMMATION

Cordycepin Inhibits Lipopolysaccharide (LPS)-Induced Tumor Necrosis Factor (TNF)-α Production via Activating AMP-Activated Protein Kinase (AMPK) Signaling

(2014) Jian-Li Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cordycepin Down-Regulates Multiple Drug Resistant (MDR)/HIF-1α through Regulating AMPK/mTORC1 Signaling in GBC-SD Gallbladder Cancer Cells

(2014) Wei-Ding Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cordycepin Induces S Phase Arrest and Apoptosis in Human Gallbladder Cancer Cells

(2014) Xu-An Wang et al.   MOLECULES

The neuroprotective effects of cordycepin inhibit glutamate-induced oxidative and ER stress-associated apoptosis in hippocampal HT22 cells

(2014) Mei Ling Jin et al.   NEUROTOXICOLOGY

Effects of cordycepin on HepG2 and EA.hy926 cells: Potential antiproliferative, antimetastatic and anti-angiogenic effects on hepatocellular carcinoma

(2014) HAISHENG LU et al.   Oncology Letters

Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways

(2014) Yung Hyun Choi et al.   Drug Design Development and Therapy

Cordycepin-mediated transcriptional regulation of human GD3 synthase (hST8Sia I) in human neuroblastoma SK-N-BE(2)-C cells

(2013) J.-S. Baik et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Cordycepin, 3′-Deoxyadenosine, Prevents Rat Hearts from Ischemia/Reperfusion Injury Via Activation of Akt/GSK-3β/p70S6K Signaling Pathway and HO-1 Expression

(2013) Eun-Seok Park et al.   Cardiovascular Toxicology

Effects of cordycepin on Y-maze learning task in mice

(2013) Zhao-Lin Cai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cordycepin Increases Nonrapid Eye Movement Sleep via Adenosine Receptors in Rats

(2013) Zhenzhen Hu et al.   Evidence-based Complementary and Alternative Medicine

Influence of treatment with 3′-deoxyadenosine associated deoxycoformycin on hematological parameters and activity of adenosine deaminase in infected mice with Trypanosoma evansi

(2013) Luciana Dalla Rosa et al.   EXPERIMENTAL PARASITOLOGY

Anti-cancer effect and apoptosis induction of cordycepin through DR3 pathway in the human colonic cancer cell HT-29

(2013) Seung Yuan Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species-mediated mitochondrial death pathway

(2013) HYE HYEON LEE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cordycepin prevented IL-β-induced expression of inflammatory mediators in human osteoarthritis chondrocytes

(2013) Xiaozhou Ying et al.   INTERNATIONAL ORTHOPAEDICS

Cordycepin activates AMP-activated protein kinase (AMPK)viainteraction with the γ1 subunit

(2013) Chongming Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Structure–Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis

(2013) Suman K. Vodnala et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of Cordycepin on the Expression of the Inflammatory Cytokines TNF-alpha, IL-6, and IL-17A in C57BL/6 Mice

(2013) Min Jeong Seo   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Peripheral Administration of Translation Inhibitors Reverses Increased Hyperalgesia in a Model of Chronic Pain in the Rat

(2013) Luiz F. Ferrari et al.   JOURNAL OF PAIN

Suppression of T-cell activation in vitro and in vivo by cordycepin from Cordyceps militaris

(2013) Ying Xiong et al.   JOURNAL OF SURGICAL RESEARCH

Blockade of Smad signaling by 3′-deoxyadenosine: a mechanism for its anti-fibrotic potential

(2013) Liubao Gu et al.   LABORATORY INVESTIGATION

Cordycepin (3′-deoxyadenosine) pentostatin (deoxycoformycin) combination treatment of mice experimentally infected with Trypanosoma evansi

(2013) LUCIANA DALLA ROSA et al.   PARASITOLOGY

Cordycepin Regulates GSK-3β/β-Catenin Signaling in Human Leukemia Cells

(2013) Bor-Sheng Ko et al.   PLoS One

OPTIMIZATION OF FERMENTATION CONDITIONS AND PURIFICATION OF CORDYCEPIN FROMCordyceps militaris

(2013) Tang Jiapeng et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Intervention in Genotoxic Stress–Induced Senescence by Cordycepin Through Activation of eIF2α and Suppression of Sp1

(2013) Liubao Gu et al.   TOXICOLOGICAL SCIENCES

Effects of Korean Red Ginseng extract on tissue plasminogen activator and plasminogen activator inhibitor-1 expression in cultured rat primary astrocytes

(2013) Hyun Myung Ko et al.   Journal of Ginseng Research

Specificity factors in cytoplasmic polyadenylation

(2013) Amanda Charlesworth et al.   Wiley Interdisciplinary Reviews-RNA

Blockade of adipocyte differentiation by cordycepin

(2012) Shuhei Takahashi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cordycepin as a sensitizer to tumour necrosis factor (TNF)-α-induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-κB

(2012) M. Kadomatsu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Ras/ERK1 pathway regulation of p27KIP1-mediated G1-phase cell-cycle arrest in cordycepin-induced inhibition of the proliferation of vascular smooth muscle cells

(2012) Su-Mi Jung et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cordycepin (3′-deoxyadenosine) attenuates age-related oxidative stress and ameliorates antioxidant capacity in rats

(2012) Thiyagarajan Ramesh et al.   EXPERIMENTAL GERONTOLOGY

Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination

(2012) Zhenghua Ren et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cordycepin Stimulated Steroidogenesis in MA-10 Mouse Leydig Tumor Cells through the Protein Kinase C Pathway

(2012) Hsiang-Yin Pao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Protective roles of Cordyceps on lung fibrosis in cellular and rat models

(2012) Mengli Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effect of Cordycepin Purified from Cordyceps militaris on Th1 and Th2 Cytokines in Mouse Splenocytes

(2012) Min-Ho Jeong   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Inflammation in Diabetic Nephropathy

(2012) Andy K. H. Lim et al.   MEDIATORS OF INFLAMMATION

Effect of Long-term Administration of Cordycepin from Cordyceps militaris on Testicular Function in Middle-aged Rats

(2012) Sang-Hyun Sohn et al.   PLANTA MEDICA

Inhibition of polyadenylation reduces inflammatory gene induction

(2012) A. Kondrashov et al.   RNA

Susceptibility of Trypanosoma evansi to cordycepin

(2011) Aleksandro S. Da Silva et al.   BIOMEDICINE & PHARMACOTHERAPY

Thein Vivoandin VitroStimulatory Effects of Cordycepin on Mouse Leydig Cell Steroidogenesis

(2011) Sew-Fen LEU et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3′-deoxyadenosine

(2011) M Kitamura et al.   CELL DEATH AND DIFFERENTIATION

Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro

(2011) Zhenyong Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Effect of Cordycepin on Steroidogenesis and Apoptosis in MA-10 Mouse Leydig Tumor Cells

(2011) Bo-Syong Pan et al.   Evidence-based Complementary and Alternative Medicine

AMP-activated protein kinase--an energy sensor that regulates all aspects of cell function

(2011) D. G. Hardie   GENES & DEVELOPMENT

Cordycepin (3′-Deoxyadenosine), an Inhibitor of mRNA Polyadenylation, Suppresses Proliferation and Activates Apoptosis in Human Epithelial Endometriotic Cells in vitro

(2011) Patrick Imesch et al.   GYNECOLOGIC AND OBSTETRIC INVESTIGATION

Beneficial effects of cordycepin on metabolic profiles of liver and plasma from hyperlipidemic hamsters

(2011) Yang Sun et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Phenylsulfanylation of 3′,4′-Unsaturated Adenosine Employing Thiophenol-N-Iodosuccinimide Leads to 4′-Phenylsulfanylcordycepin: Synthesis of 4′-Substituted Cordycepins on the Basis of Substitution of the Phenylsulfanyl Leaving Group

(2011) Yutaka Kubota et al.   JOURNAL OF ORGANIC CHEMISTRY

Cordycepin Inhibits Renal Interstitial Myofibroblast Activation Probably by Inducing Hepatocyte Growth Factor Expression

(2011) Li Li et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

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(2011) Hogyoung Kim et al.   MOLECULAR MEDICINE

Cordycepin-induced apoptosis and autophagy in breast cancer cells are independent of the estrogen receptor

(2011) Sunga Choi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells

(2011) Jin-Woo Jeong et al.   TOXICOLOGY IN VITRO

MLH1-deficient HCT116 colon tumor cells exhibit resistance to the cytostatic and cytotoxic effect of the poly(A) polymerase inhibitor cordycepin (3′-deoxyadenosine) in vitro

(2011) PATRICK IMESCH et al.   Oncology Letters

Improvement on Lipid Metabolic Disorder by 3′-Deoxyadenosine in High-Fat-Diet-Induced Fatty Mice

(2010) Ya-Jing Niu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans

(2010) Marie-Soleil Gauthier et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Research Article: Binding of Cordycepin Monophosphate to AMP-Activated Protein Kinase and its Effect on AMP-Activated Protein Kinase Activation

(2010) Zhanli Wang et al.   Chemical Biology & Drug Design

Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells

(2010) Jin-Woo Jeong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cordycepin Induces Apoptosis of CGTH W-2 Thyroid Carcinoma Cells through the Calcium−Calpain−Caspase 7-PARP Pathway

(2010) Ying Chen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pharmacokinetics of Adenosine and Cordycepin, a Bioactive Constituent ofCordyceps sinensisin Rat

(2010) Yung-Jen Tsai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Cordycepin Prevents Hyperlipidemia in Hamsters Fed a High-Fat Diet via Activation of AMP-Activated Protein Kinase

(2010) Peng Guo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Cordycepin induces apoptosis by enhancing JNK and p38 kinase activity and increasing the protein expression of Bcl-2 pro-apoptotic molecules

(2010) Wei He et al.   Journal of Zhejiang University-SCIENCE B

The role of cytoplasmic polyadenylation element sequence on mRNA abundance during porcine embryogenesis and parthenogenetic development

(2010) Kyle B. Dobbs et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control

(2010) Isabel Novoa et al.   NATURE CELL BIOLOGY

Cordycepin suppresses TNF-alpha-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells

(2010) Eo-Jin Lee et al.   PHYTOTHERAPY RESEARCH

Role of Cordycepin and Adenosine on the Phenotypic Switch of Macrophages via Induced Anti-inflammatory Cytokines

(2010) Seulmee Shin et al.   Immune Network

Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-Jun N-terminal kinase activation in human bladder cancer cells

(2009) Se-Jung Lee et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Cordycepin Induced MA-10 Mouse Leydig Tumor Cell Apoptosis through Caspase-9 Pathway

(2009) Chun-Yi Jen et al.   Evidence-based Complementary and Alternative Medicine

c-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells

(2009) Se-Jung Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Cordycepin Inhibits Protein Synthesis and Cell Adhesion through Effects on Signal Transduction

(2009) Ying Ying Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cordycepin Attenuates Neointimal Formation by Inhibiting Reactive Oxygen Species–Mediated Responses in Vascular Smooth Muscle Cells in Rats

(2009) Kyung-Jong Won et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Proteomic detection of changes in protein expression induced by cordycepin in human hepatocellular carcinoma BEL-7402 cells

(2009) P. Shi et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Involvement of polyadenylation status on maternal gene expression during in vitro maturation of porcine oocytes

(2009) Ding-Xiao Zhang et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

Cordycepin interferes with 3' end formation in yeast independently of its potential to terminate RNA chain elongation

(2009) S. Holbein et al.   RNA

Preclinical Assessment of the Treatment of Second-Stage African Trypanosomiasis with Cordycepin and Deoxycoformycin

(2009) Suman K. Vodnala et al.   PLoS Neglected Tropical Diseases

Cordycepin Suppresses Expression of Diabetes Regulating Genes by Inhibition of Lipopolysaccharide-induced Inflammation in Macrophages

(2009) Seulmee Shin et al.   Immune Network

Cordycepin is an Immunoregulatory Active Ingredient of Cordyceps sinensis

(2008) Xiaoxia Zhou et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Cordycepin inhibits vascular smooth muscle cell proliferation

(2008) Woochul Chang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A Molecular Circuit Composed of CPEB-1 and c-Jun Controls Growth Hormone-Mediated Synaptic Plasticity in the Mouse Hippocampus

(2008) N. R. Zearfoss et al.   JOURNAL OF NEUROSCIENCE

A Phytochemically Characterized Extract of Cordyceps militaris and Cordycepin Protect Hippocampal Neurons from Ischemic Injury in Gerbils

(2008) In Hwang et al.   PLANTA MEDICA

Cordycepin inhibits IL-1 -induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts

(2008) E.-M. Noh et al.   RHEUMATOLOGY