Article
Chemistry, Multidisciplinary
Ryo Miyahara, Yosuke Taniguchi
Summary: The formation of unnatural base pairs within duplex DNA is important for DNA nanotechnology and biotechnology. In this study, the authors investigated the use of iso-2'-deoxyguanosine (iso-dG) as an unnatural base pair. They focused on pseudo-dC (psi dC) as a molecule that recognizes 2-hydroxy-2'-deoxyadenosine (2-OH-dA) in DNA. Through synthesis and analysis, the authors demonstrated that psi dC can form stable base pairs with 2-OH-dA, suggesting its potential applications in DNA manipulation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Physical
Shu R. Huang, Gabriela Novakova, Ales Marek, Frantisek Turecek
Summary: The study reports the targeted synthesis of gas-phase 9-methylene(1H)adenine cation radical and its unique collision-induced dissociation and UV-vis photodissociation action spectra. Computational analysis was performed to identify the global energy minimum of the cation radical and to explain the dissociation mechanisms. Additionally, a computational study of noncanonical isomers of 2'-deoxyadenosine cation radical was conducted to investigate their stability and ion-electron recombination energies.
JOURNAL OF PHYSICAL CHEMISTRY A
(2021)
Article
Chemistry, Organic
Yurino Oku, Misaki Kai, Saika Kobayashi, Ryuzi Katoh, Yoshio Saito
Summary: Two novel acyclic environment-sensitive fluorescent nucleosides ac37zA and an37zA were synthesized and their photophysical properties were investigated. Both ac37zA and an37zA showed dual fluorescence emission depending on molecular coplanarity. Oligodeoxynucleotide probes containing ac37zA clearly discriminate perfectly matched thymine in target DNA strands by strong charge transfer (CT) emission in the longer wavelength region and by strong quenching of emission from the twisted conformation in the mismatched case.
Article
Multidisciplinary Sciences
S. Sharmila Tagore, J. Swaminathan, D. Manikandan, S. Gomathi, N. Sabarinathan, M. Ramalingam, V. Sethuraman
Summary: In this study, the molecule of interest (R)-9-(2-hydroxy propyl)adenine (HPA) was investigated for its structural features using X-ray diffraction from single crystal. HPA exhibited very good second harmonic generation (SHG) activity due to its crystallization in a non-centro symmetric space group. The experimental results showed good agreement with theoretical predictions, confirming the accuracy of the analysis and studies conducted.
Article
Chemistry, Multidisciplinary
Claudia A. Blindauer, Antonin Holy, Astrid Sigel, Bert P. Operschall, Rolf Griesser, Helmut Sigel
Summary: HPMPA is an antiviral substance with interesting acid-base behavior. By measuring the chemical shifts of the protons in HPMPA, the protonation sites and acidity constants were determined. The phosphonate group is the most basic site, followed by the N1 position of adenine. The basicity of the adenine nitrogens decreases in the order N1 > N7 > N3.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Organic
Xiaoping Xue, Biqiong Hong, Jia Feng, Zhenhua Gu
Summary: An Oxone-mediated oxidative ring-opening reaction was reported for the synthesis of 2-hydroxy-2'-aroyl-1,1'-biaryls by cleaving a carbon-carbon bond of 4,5-disubstituted 9H-fluoren-9-ols. The reaction can be efficiently carried out by heating a mixture of fluoren-9-ols, Oxone, and 1,1,1,3,3,3-hexafluoroisopropanol at 60 degrees C for 4 hours. The proposed persulfate-involved ring-expansion processes were supported by DFT calculations.
Article
Chemistry, Applied
Rong Yang, Yang Xiao, Xue-bing Tao, Ming-jie Ma, Zhi-lin Wu, Li-fu Liao, Xi-lin Xiao, Chang-ming Nie
Summary: The novel receptor Uranyl-HTTDN showed high enantioselectivity towards chiral organophosphorus pesticides R/S-MAPs and R/S-APs by complexation with uranyl. This provides valuable theoretical reference and information for further experiments on the separation of COPs.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Engineering, Biomedical
William Marcondes Facchinatto, Joana Galante, Leticia Mesquita, Daniella Souza Silva, Danilo Martins dos Santos, Tiago Bueno Moraes, Sergio Paulo Campana-Filho, Luiz Alberto Colnago, Bruno Sarmento, Jose das Neves
Summary: This study explored the use of novel nanoparticles as carriers for clotrimazole, demonstrating good drug release properties and improved drug permeability in cell monolayer models.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Physical
Hisakazu Miyamoto, Hiroki Takahashi
Summary: The title compounds, 3-(p-phenylphenyl)-3-hydroxy-N-isopropyl-4,4-dimethylazetidin-2-one (2d) and 3-phenyl-3-hydroxy-N-isopropyl-4,4-dimethylazetidin-2-one (2a), were synthesized by photoreaction of N,N-diisopropyl(p-phenylphenyl)glyoxylamide 1d and N,N-diisopropylphenylglyoxylamide 1a, respectively, in solution. The formation of the compounds was confirmed by various spectroscopic techniques and X-ray diffraction. The crystal structures of compounds 2d and 2a belong to the orthorhombic and monoclinic systems, with space groups Pna2(1) and P2(1)/c, respectively.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Review
Chemistry, Organic
Mizzanoor Rahaman, M. Shahnawaz Ali, Khorshada Jahan, Jawad Bin Belayet, A. F. M. Towheedur Rahman, M. Mahmun Hossain
Summary: The discovery of 3-hydroxy-2-aryl acrylate has been a significant breakthrough, serving as a pivotal building block in the synthesis of bioactive compounds and essential drugs. This scaffold, with its electrophilic and nucleophilic centers, plays a crucial role in various chemical fields.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Medicinal
Victoria C. Yan, Cong-Dat Pham, Elliot S. Ballato, Kristine L. Yang, Kenisha Arthur, Sunada Khadka, Yasaman Barekatain, Prakriti Shrestha, Theresa Tran, Anton H. Poral, Mykia Washington, Sudhir Raghavan, Barbara Czako, Federica Pisaneschi, Yu-Hsi Lin, Nikunj Satani, Naima Hammoudi, Jeffrey J. Ackroyd, Dimitra K. Georgiou, Steven W. Millward, Florian L. Muller
Summary: This study aimed to improve the treatment efficacy for cancers with homozygous deletion of enolase 1 (ENO1) by identifying potential non-esterase prodrugs. The findings showed that phosphonoamidate esters were efficiently bioactivated, while McGuigan prodrugs failed to achieve the same effect. In addition, cycloSal and lipid prodrugs demonstrated good inhibitory activity and stability at the cellular level.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Vijaya C. Lakshmi, Naresh Kumar Katari, Giri M. Prasad, Nagaraju Kerru, Vijay Kumar Rekulapally, Sreekantha B. Jonnalagadda
Summary: An efficient protocol for synthesis of Erythro (+/-) and Threo (+/-) is described, with excellent yields achieved through simple reduction and inversion method. The method is cost-effective, high-yielding, and suitable for large-scale synthesis.
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Xiao-Xiao Yu, Peng Zhao, You Zhou, Chun Huang, Li-Sheng Wang, Yan-Dong Wu, An-Xin Wu
Summary: The novel iodine promoted cyclization reaction provides a straightforward method for constructing 2-hydroxy-pyrrol-3(2H)-ones from enaminones and aryl methyl ketones. This strategy yields structurally diverse 2-hydroxy-pyrrol-3(2H)-ones rings in high yields and efficiently constructs a quarternary alcohol. Product purification is simplified by washing with CH2Cl2 solvent, showcasing an example of group-assisted purification chemistry.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Abinash Pradhan, Saroj L. Samal
Summary: Antimony substitution in (EA)(3)Bi2-2x Sb2x I9 caused a structural transition from the 0D hexagonal phase containing isolated [M2I9](3-) (M = Bi/Sb) units to the orthorhombic phase containing infinite 1D chains of [(Bi/Sb)(2)I-9 (3-)]. The exploration of these new phases and understanding their properties is crucial in the development of materials for solar cell applications.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Hiroki Mandai, Ryuhei Shiomoto, Kazuki Fujii, Koichi Mitsudo, Seiji Suga
Summary: An efficient acylative kinetic resolution method for 3-hydroxy-3-substituted 2-oxindoles has been developed using a chiral DMAP derivative. The catalyst showed high efficiency with a wide range of substrates and could achieve high resolution within a short reaction time.
Article
Infectious Diseases
Daiane Heidrich, Valeriano Antonio Corbellini, Sandra Denise Camargo Mendes, Elissa Kerli Fernandes, Leticia Lazzarotto, Amanda Carvalho Ribeiro, Regis Adriel Zanette, Maria Lucia Scroferneker
Article
Infectious Diseases
Carla Weiblena, Regis Adriel Zanette, Tatiana Correa Ribeirob, Carlos Eduardo Pereira dos Santos, Lara Baccarin Ianiski, Daniela Isabel Brayer Pereira, Janio Morais Santuriob, Sonia de Avila Botton
Article
Biochemistry & Molecular Biology
Carine de Freitas Souzs, Matheus Dellamea Baldissera, Bernardo Baldisserotto, Tiago G. Petrolli, Eduardo Micotti da Gloria, Regis A. Zanette, Aleksandro S. Da Silva
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2020)
Article
Mycology
E. S. Loreto, J. S. M. Tondolo, F. P. K. de Jesus, A. M. Engelmann, C. M. de Andrade, J. M. Santurio, R. A. Zanette, G. D. Kommers, T. M. Silva, S. H. Alves
JOURNAL DE MYCOLOGIE MEDICALE
(2020)
Article
Dermatology
Carla Weiblen, Lizandra Jaqueline Robe, Maria Isabel de Azevedo, Lara Baccarin Ianiski, Paula Cristina Stibbe, Tatiana Correa Ribeiro, Regis Adriel Zanette, Daniela Isabel Brayer Pereira, Janio Morais Santurio, Sonia de Avila Botton
Article
Infectious Diseases
Daiane Flores Dalla Lana, Tais Fernanda Andrzejewski Kaminski, Stefania Neiva Lavorato, Simone Merkel, Regis Adriel Zanette, Priscila Dalle da Rosa, Keli Jaqueline Staudt, Bibiana Verlindo de Araujo, Barbara Costa, Priscilla Maciel Quatrin, Luana Candice Genz Bazana, Felipe Alves Ferreira, Cassia Ferreira Braz Caurio, Saulo Fernandes de Andrade, Ricardo Jose Alves, Alexandre Meneghello Fuentefria
Article
Biotechnology & Applied Microbiology
B. Pippi, A. R. Joaquim, S. Merkel, R. A. Zanette, M. E. M. Nunes, D. G. da Costa Silva, L. E. Schimith, M. L. Teixeira, J. L. Franco, S. Fernandes de Andrade, A. M. Fuentefria
Summary: The study evaluated the antifungal activity and toxicology parameters of 8-hydroxyquinoline derivatives PH151 and PH153 using alternative animal models. The compounds showed potential for treating systemic candidiasis with low toxicity and were suitable for further development as new drug candidates.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Infectious Diseases
Alessandra Helena da Silva Hellwig, Danielle Machado Pagani, Iasmin da Silva Rios, Amanda Carvalho Ribeiro, Regis A. Zanette, Maria Lucia Scroferneker
Summary: The growth of S. brasiliensis isolates was more affected by iron availability compared to S. schenckii, while both fungal species conidia became more prone to oxidative stress when exposed to iron in culture medium. However, the combination of itraconazole and deferasirox only resulted in synergism against a minority of S. schenckii isolates.
Article
Microbiology
Alexandre Ehrhardt, Jessica Zolim Andreatto Mandelli, Vanessa Bergamo, William Lopes, Ricardo Keitel Donato, Regis A. Zanette, Alexandre Meneghello Fuentefria
Summary: Researchers successfully developed a new biomaterial with antifungal biofilm activity by modifying a commercially available glass ionomer cement with a specific component. The modified cement showed strong antibiofilm activity against multiple drug-resistant Candida species, while maintaining its original micromechanical and hypoallergenic properties, making it a promising candidate for dental applications.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2021)
Review
Parasitology
Beni Jequicene Mussengue Chauque, Thaisla Cristiane Borella da Silva, Denise Leal dos Santos, Guilherme Brittes Benitez, Leosvilda Gomes Henriques Chauque, Antonio Domingues Benetti, Regis Adriel Zanette, Marilise Brittes Rott
Summary: The ubiquitous free-living amoebae (FLA) are microorganisms of significant medical, sanitary, and ecological importance. However, their characterization within solid matrices such as soil, dust, sediment, mud, sludge, and compost remain to be systematized. In this study, a systematic review with meta-analysis was conducted to explore the global distribution of FLA in solid matrices. The analysis of 104 out of 4,414 scientific articles revealed that FLA prevalence in solid matrices was 55.13% globally. Soil had the highest prevalence (72.40%), followed by sediment (57.91%), mud (52.90%), dust (48.60%), and sewage sludge (40.19%). Acanthamoeba spp. (52.23%) and Hartmanella/Vermamoeba spp. (36.06%) were the most prevalent FLA species.
Article
Dermatology
Barbara da Costa, Bruna Pippi, Simone Merkel, Giovanna Agostinetto, Regis A. Zanette, Alexandre M. Fuentefria
Summary: This study validates Drosophila melanogaster flies as a suitable model to study dermatophytic infections. It shows that wild-type flies are resistant to infection, while Toll-deficient flies are susceptible. Antifungal drugs can protect flies from infection, except for one specific fungus.
Article
Veterinary Sciences
Diorges H. Setim, Carlos Bondan, Caroline C. Cortese, Jessica C. Peretti, Fernanda L. Facioli, Ricardo Zanella, Marcio M. Costa, Adriana C. da Motta
Summary: This study aimed to verify the presence of bovine paratuberculosis in commercial dairy herds in different mesoregions of RS, Brazil. Indirect ELISA tests and PCR were performed on milk and fecal samples, respectively. The results indicated that paratuberculosis is likely endemic in the northwest and northeast mesoregions.
PESQUISA VETERINARIA BRASILEIRA
(2023)
Article
Veterinary Sciences
J. H. Silva, L. V. Q. Contreras, C. F. Ponath, C. Bondan, M. C. Machado, F. Gonzalez
Summary: The study aimed to investigate the impact of pre and postpartum DCAD on serum calcium, phosphorus, and magnesium levels in peripartum Holstein cows. Blood samples were collected from 56 cows (18 primiparous and 38 multiparous) on different days relative to parturition to analyze mineral levels, while diet and urine samples were also collected. Prepartum DCAD showed a positive correlation with total and corrected calcium levels at day-7, and a negative correlation with magnesium levels at day-7. However, prepartum DCAD did not significantly affect phosphorus levels. Postpartum DCAD did not have any correlation with serum mineral levels. The study highlights the importance of considering parity and time period when evaluating mineral levels in Holstein cows during the transition period.
ARQUIVO BRASILEIRO DE MEDICINA VETERINARIA E ZOOTECNIA
(2023)
Article
Biotechnology & Applied Microbiology
Bruna Pippi, Regis A. Zanette, Angelica R. Joaquim, Maria E. Krummenauer, Simone Merkel, Paula Reginatto, Marilene H. Vainstein, Saulo F. Andrade, Alexandre M. Fuentefria, Juliana S. M. Tondolo, Erico S. Loreto, Janio M. Santurio
Summary: This study evaluates the antimicrobial activity of three 8-hydroxyquinoline derivatives against Pythium insidiosum and determines their pharmacodynamic characteristics. Results show that Clioquinol, PH151, and PH153 are active against all isolates, with MIC values ranging from 0.25 to 2 μg/mL. They also exhibit a time- and dose-dependent antimicrobial effect, damaging the P. insidiosum cell wall. These findings reinforce the potential of 8-hydroxyquinoline derivatives as new drugs for treating pythiosis.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Andrielli Trentim Pereira, Ana Paula Maurique Pereira, Inazio Manassi Conceicao da Brandolt, Ricardo Pozzobon, Marcio Machado Costae, Bruno Leite dos Anjos, Saulo Pavarini
SEMINA-CIENCIAS AGRARIAS
(2020)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)