Article
Oncology
Cheng Wang, Wencheng Zhang, Wenjing Xu, Zhaoyu Liu, Kai Huang
Summary: This study found that hepatic AMPK alpha 1 plays an essential role in maintaining iron homeostasis by regulating hepcidin through its interaction with PHD2. This discovery provides a new potential approach for treating iron disturbances in chronic diseases.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Shan-Qi Mou, Zi-Ying Zhou, Hong Feng, Nan Zhang, Zheng Lin, Xiahenazi Aiyasiding, Wen-Jing Li, Wen Ding, Hai-Han Liao, Zhou-Yan Bian, Qi-Zhu Tang
Summary: LIQ administration attenuates LPS-induced cardiac dysfunction and reduces mortality by regulating AMPK alpha 2 dependent signaling pathway, thereby reducing inflammation, oxidative stress, apoptosis, and metabolic alterations.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu-Hsu Chen, Kuang-Kai Hsueh, Pei-Wen Chu, Shau-Kwaun Chen
Summary: AMP-activated protein kinase (AMPK) is a critical metabolic regulator that affects immune cell functions such as macrophages and osteoclasts. AMPK plays a key role in promoting anti-inflammatory responses in macrophages and negatively regulating osteoclastogenesis.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kaitlin R. Morrison, Tingting Wang, Kuan Yoow Chan, Eleanor W. Trotter, Ari Gillespie, Michael Z. Michael, Jonathan S. Oakhill, Iain M. Hagan, Janni Petersen
Summary: The expression and activity of AMPK alpha 1 catalytic subunit are significantly associated with poor prognosis in colorectal cancer patients. By attenuating mTOR control of AMPK alpha 1, a mutant colorectal cancer cell line with elevated AMPK alpha 1 signaling was generated. This elevated signaling confers hypersensitivity to metformin-induced growth inhibition, suggesting a potential role for metformin in colorectal cancer therapy.
Review
Biochemistry & Molecular Biology
Ashley J. Ovens, John W. Scott, Christopher G. Langendorf, Bruce E. Kemp, Jonathan S. Oakhill, William J. Smiles
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in adaptive responses to exercise, and its post-translational modifications extensively influence its activity, subcellular localization, nutrient interactions, and protein stability. Areas for further research include novel regulatory modifications of AMPK and improving characterization of these modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Mingzhu Pan, Jiahuan Liu, Dong Huang, Yanlin Guo, Kai Luo, Mengxi Yang, Weihua Gao, Qiaoqing Xu, Wenbing Zhang, Kangsen Mai
Summary: This study characterized the foxo3 in turbot and investigated its functions in liver inflammation through both in vitro and in vivo experiments. The results suggest that FoxO3 may modulate LPS-activated hepatic inflammation in turbot by decreasing proinflammatory cytokines, levels of liver enzymes, and activating specific pathways, providing valuable insights for immune regulation and potential therapies for liver inflammation in fish.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Emilia Przygrodzka, Corrine F. Monaco, Michele R. Plewes, Guojuan Li, Jennifer R. Wood, Andrea S. Cupp, John S. Davis
Summary: The study revealed that in bovine luteal cells, autophagy pathway activated by AMPK was increased during PGF2α-induced luteolysis, while the LH/PKA signaling pathway inhibited autophagy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xuechen Li, Zhengbing Zhuge, Lucas Rannier R. A. Carvalho, Valdir A. Braga, Ricardo Barbosa Lucena, Shuijie Li, Tomas A. Schiffer, Huirong Han, Eddie Weitzberg, Jon O. Lundberg, Mattias Carlstrom
Summary: The study indicates that treatment with inorganic nitrate and nitrite can attenuate the development of kidney fibrosis by targeting oxidative stress and lipid metabolism. Mechanisms include modulation of AMPK and AKT-PGC1α pathways.
Article
Cell Biology
Malgorzata Tokarska-Schlattner, Laurence Kay, Pascale Perret, Raffaella Isola, Stephane Attia, Frederic Lamarche, Cindy Tellier, Cecile Cottet-Rousselle, Amjad Uneisi, Isabelle Hininger-Favier, Marc Foretz, Herve Dubouchaud, Catherine Ghezzi, Christian Zuppinger, Benoit Viollet, Uwe Schlattner
Summary: AMPK, a key regulator of energy homeostasis, plays important roles in maintaining cardiac function under increased workload conditions. Deletion of AMPK genes in cardiomyocytes did not affect heart function under physiological conditions, but led to alterations in response to increased workload. AMPK deletion also resulted in decreased basal metabolic rate and locomotor activity, along with changes in cardiac mitochondrial function and bioenergetics.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Min Zhang, Li Wei, Saiyang Xie, Yun Xing, Wenke Shi, Xiaofeng Zeng, Si Chen, Shasha Wang, Wei Deng, Qizhu Tang
Summary: Lithospermic acid (LA) pretreatment protects against myocardial ischemia-reperfusion injury by activating eNOS and Nrf2/HO-1 signaling, reducing infarct size and improving cardiac function.
LA ameliorates oxidative stress and cardiomyocyte apoptosis, playing a crucial role in heart function and pathology.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Xin Wang, Xueyan Zhou, Beth Uberseder, Jingyun Lee, Caitlin S. Latimer, Cristina M. Furdui, C. Dirk Keene, Thomas J. Montine, Thomas C. Register, Suzanne Craft, Carol A. Shively, Tao Ma
Summary: The study on NHP model demonstrated an increased activity of AMPK alpha 2 in AD-like neuropathology, unrelated to AMPK alpha 1; CSF Abeta(42) showed a negative correlation with cerebral amyloid plaque density; A beta plaque burden correlated with brain A beta measurement levels.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Immunology
Kuluvar Gouthannchandra, Heggar Venkataramana Sudeep, Siddappa Chandrappa, Amrith Raj, Puttaswamy Naveen, Kodimule Shyamaprasad
Summary: In this study, bisdemethoxycurcumin (BDMC) was enriched to 70% and named as REVERC3 for the first time, showing significant anti-inflammatory activity in comparison to regular turmeric extract. The results demonstrated that REVERC3 effectively inhibited inflammation processes in both in vitro and in vivo models.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
S-M Ju, J. S. Bae, B-H Jeon
Summary: The study found that cisplatin induces apoptotic cell death through ROS-mediated p53 activation, which is associated with AMPK activation. AMPK inhibitor can suppress cisplatin-induced p53 activation, while ROS scavenger can also diminish p53 and AMPK activation. Additionally, cisplatin induces phosphorylation of eIF2 alpha, which attenuates p53 activation, but does not affect the expression levels of total p53, cleaved caspase-3 and PARP.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jae Eun Park, Ji Sook Han
Summary: In this study, we investigated the effects of HM-chromanone on glucose production in hepatocytes. HM-chromanone was found to inhibit hepatic glucose production, increase glycogen synthesis, and suppress the expression of genes involved in glucose production. These effects were mediated by the activation of AMPK and the phosphorylation of key proteins involved in glucose metabolism.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Young Eun Kim, Seon-Been Bak, Min-Jin Kim, Su-Jin Bae, Won-Yung Lee, Young Woo Kim
Summary: This study demonstrates the protective effects of forsythiaside A (FA) against oxidative stress, attenuating cell damage caused by reactive oxygen species (ROS) through the activation of AMP-activated protein kinase (AMPK) and the modulation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)