Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial

(2018) Victor Kande Betu Ku Mesu et al.   LANCET

Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity

(2018) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Human African trypanosomiasis

(2017) Philippe Büscher et al.   LANCET

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

(2016) Jadd Shelton et al.   CHEMICAL REVIEWS

Approved Antiviral Drugs over the Past 50 Years

(2016) Erik De Clercq et al.   CLINICAL MICROBIOLOGY REVIEWS

Trypanosoma bruceiMethylthioadenosine Phosphorylase Protects the Parasite from the Antitrypanosomal Effect of Deoxyadenosine

(2016) Munender Vodnala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current status on prevention and treatment of canine leishmaniasis

(2016) Rosa M. Reguera et al.   VETERINARY PARASITOLOGY

Characterization of a Novel Endoplasmic Reticulum Protein Involved in Tubercidin Resistance in Leishmania major

(2016) Juliana Ide Aoki et al.   PLoS Neglected Tropical Diseases

Reduced Mitochondrial Membrane Potential Is a Late Adaptation of Trypanosoma brucei brucei to Isometamidium Preceded by Mutations in the γ Subunit of the F1Fo-ATPase

(2016) Anthonius A. Eze et al.   PLoS Neglected Tropical Diseases

Stability of Reference Genes for Messenger RNA Quantification by Real-Time PCR in Mouse Dextran Sodium Sulfate Experimental Colitis

(2016) Nour Eissa et al.   PLoS One

Nitroheterocyclic drug resistance mechanisms inTrypanosoma brucei

(2015) Susan Wyllie et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Functional analysis of drug resistance-associated mutations in theTrypanosoma bruceiadenosine transporter 1 (TbAT1) and the proposal of a structural model for the protein

(2015) Jane C. Munday et al.   MOLECULAR MICROBIOLOGY

GMP synthase is essential for viability and infectivity ofTrypanosoma bruceidespite a redundant purine salvage pathway

(2015) Qiong Li et al.   MOLECULAR MICROBIOLOGY

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

(2015) Imanol Peña et al.   Scientific Reports

Diagnosis of Trypanosomatid Infections

(2014) Pablo González-Andrade et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

A Panel of Trypanosoma brucei Strains Tagged with Blue and Red-Shifted Luciferases for Bioluminescent Imaging in Murine Infection Models

(2014) Nick Van Reet et al.   PLoS Neglected Tropical Diseases

Inhibition of Isoleucyl-tRNA Synthetase as a Potential Treatment for Human African Trypanosomiasis

(2013) Igor Cestari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure–Activity Relationships of Synthetic Cordycepin Analogues as Experimental Therapeutics for African Trypanosomiasis

(2013) Suman K. Vodnala et al.   JOURNAL OF MEDICINAL CHEMISTRY

A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis

(2013) Peter Babokhov et al.   Pathogens and Global Health

Clinical features, diagnosis, and treatment of human African trypanosomiasis (sleeping sickness)

(2012) Peter GE Kennedy   LANCET NEUROLOGY

Development of novel drugs for human African trypanosomiasis

(2011) Reto Brun et al.   Future Microbiology

Evaluation of Nucleoside Hydrolase Inhibitors for Treatment of African Trypanosomiasis

(2010) M. Berg et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis

(2010) A. Y. Sokolova et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?

(2010) M. Berg et al.   CURRENT MEDICINAL CHEMISTRY

Selection of reference genes for mRNA quantification in Trypanosoma brucei

(2010) Martin Brenndörfer et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters

(2010) Gabriela Schumann Burkard et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Predictive Computational Models of Substrate Binding by a Nucleoside Transporter

(2009) Catharine J. Collar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preclinical Assessment of the Treatment of Second-Stage African Trypanosomiasis with Cordycepin and Deoxycoformycin

(2009) Suman K. Vodnala et al.   PLoS Neglected Tropical Diseases

The continuing problem of human African trypanosomiasis (sleeping sickness)

(2008) Peter G. E. Kennedy   ANNALS OF NEUROLOGY