Article
Immunology
Shuwei Zheng, Ke Huang, Wenjie Xia, Jiahao Shi, Qiuli Liu, Xiaoran Zhang, Gang Li, Jieying Chen, Tao Wang, Xiaoyong Chen, Andy Peng Xiang
Summary: Activated T cells can rapidly adhere to MSCs, leading to a significant reduction in proinflammatory cytokine expression. MSCs rapidly suppress TCR signaling and downstream pathways in a cell-cell contact-dependent manner, partially through the ICAM-1/CD43 adhesion interaction.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Paul Shafer, Lauren M. Kelly, Valentina Hoyos
Summary: This article presents a review of the use of engineered T cells for cancer therapy. The mechanisms of T cell antigen recognition and signal transduction mediated through CARs and TCRs are discussed, along with the current classes of cancer antigens recognized by TCR T therapies and pre-clinical strategies for TCR discovery and enhancement. The current landscape of clinical trials for TCR T therapy is also reviewed, providing insights into the development of future engineered TCR approaches.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yuanyuan Liu, Shuai Chen, Simon Liu, Kevin L. Wallace, Marietta Zille, Jiewen Zhang, Jian Wang, Chao Jiang
Summary: Stroke is a severe and life-threatening disease that requires more research on new treatment strategies. Infiltrated T lymphocytes play a crucial role in post-stroke inflammation and have conflicting roles as therapeutic targets. Understanding the mechanisms of the adaptive immune response associated with T lymphocytes is essential for developing effective treatments.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Immunology
Mikiya Tsunoda, Hiroyasu Aoki, Haruka Shimizu, Shigeyuki Shichino, Kouji Matsushima, Satoshi Ueha
Summary: Temporal analysis of T cell receptor (TCR) repertoire is important for monitoring changes in antigen-specific T cells in cancer patients. However, lack of experimental models for temporal analysis within a homogeneous population limits understanding of the relationship between TCR repertoire changes and antitumor responses. Bilateral tumor model showed highly similar T-cell clones in bilateral tumors and different patterns in draining lymph nodes, suggesting independent induction of tumor-reactive T cell clones in each lymph node.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Matthew Clark, Charles J. Kroger, Qi Ke, Roland M. Tisch
Summary: TCR signaling plays a crucial role in the development of T cells and the formation of self-reactive T cells, particularly in type 1 diabetes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
John C. Charpentier, Philip D. King
Summary: Endocytosis, once primarily viewed as a means to neutralize pathogens or facilitate feeding, is now known to regulate a wide range of eukaryotic cell processes, including signal transduction, mitosis, lipid homeostasis, and directed migration. Various forms of endocytosis play important roles in regulating alpha beta and gamma delta T cell functions, such as T cell receptor signaling, antigen discovery by trogocytosis, and activated cell growth. This article examines the contribution of both clathrin-mediated and clathrin-independent mechanisms of endocytosis to T cell biology.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Medicine, Research & Experimental
Baiyi Yan, Yanchun Gong, Wei Meng, Huizhen Sun, Wenxi Li, Kaizhi Ding, Caixia Dang, Xiaofei Gao, Wei Sun, Chunhua Yuan, Songhua Wang, Li-Hua Yao
Summary: This study found that cordycepin, an extract from Cordyceps militaris, has a significant protective effect on glucotoxicity and lipotoxicity-induced damage in pancreatic islet cells. It improves cell viability, energy metabolism, and insulin synthesis and secretion. The mechanism may involve reducing ROS levels, increasing ATP content, causing membrane depolarization, balancing Ca2+ concentration, and inhibiting cell apoptosis through downregulation of the JNK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Aldo Borroto, Balbino Alarcon, Maria N. Navarro
Summary: T gamma delta 17 cells play a key role in inflammatory and autoimmune diseases. The role of TCR signaling in the generation and function of T gamma delta 17 cells is not fully understood. The intact CD3 epsilon-PRS sequence is required for optimal differentiation and pathogenic function of T gamma delta 17 cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
June Guha, Raj Chari
Summary: DLG1 plays a crucial role in regulating T cell activation by promoting TCR-MC formation even before immunological synapse formation. Additionally, DLG1 acts as a bridge between TCR-ζ chain and ZAP70 while inhibiting the binding of phosphatase SHP1 to TCR-ζ. These effects ultimately lead to dysregulation of T cell activation in DLG1-deficient T cells, impacting vaccine response strategies.
Review
Biochemistry & Molecular Biology
Jiangping Li, Zhiwen Xiao, Donghui Wang, Lei Jia, Shihong Nie, Xingda Zeng, Wei Hu
Summary: Recent advancements in neoantigen research have accelerated the development of tumor immunotherapies, particularly for solid tumors, including adoptive cell therapies, cancer vaccines, and antibody-based therapies. The use of next-generation sequencing and bioinformatics technology enables the rapid identification and prediction of tumor-specific antigens, which not only provide new targets for personalized tumor immunotherapy but also serve as potential indicators for predicting tumor patient survival, prognosis, and immune checkpoint blockade response.
Article
Immunology
Ayush Madhok, Sajad Ahmad Bhat, Chinna Susan Philip, Shalini Kashipathi Sureshbabu, Shubhada Chiplunkar, Sanjeev Galande
Summary: The study elucidated the transcriptional changes in Vγ9Vδ2 T cells upon HDMAPP, IPP, and anti-CD3 treatments in combination with IL2 stimulation, as well as the impact of Notch signaling inhibition on these activation treatments. The results highlighted a transcriptional crosstalk between TCR signaling and Notch signaling in Vγ9Vδ2 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
George Elias, Pieter Meysman, Esther Bartholomeus, Nicolas De Neuter, Nina Keersmaekers, Arvid Suls, Hilde Jansens, Aisha Souquette, Hans De Reu, Marie-Paule Emonds, Evelien Smits, Eva Lion, Paul G. Thomas, Geert Mortier, Pierre Van Damme, Philippe Beutels, Kris Laukens, Viggo Van Tendeloo, Benson Ogunjimi
Summary: This study demonstrates the significant impact of preexisting memory CD4 T cell clones on vaccine-induced immunity to hepatitis B. The presence of these clones can predict the strength and timing of the immune response to vaccination.
Article
Oncology
Alaa Madi, Nina Weisshaar, Michael Buettner, Gernot Poschet, Sicong Ma, Jingxia Wu, Alessa Mieg, Marvin Hering, Yanan Ming, Kerstin Mohr, Nora ten Bosch, Guoliang Cui
Summary: CD8 agonism activates memory T cell metabolism and enhances the efficacy of memory T cell-based cancer immunotherapy.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Integrative & Complementary Medicine
Chang-Wen Ku, Tsung-Jung Ho, Chih-Yang Huang, Pei-Ming Chu, Hsiu-Chung Ou, Pei-Ling Hsieh
Summary: Cordycepin, the main bioactive chemical of Cordyceps sinensis, has potent anticancer, anti-oxidant and anti-inflammatory activities. In addition, its protective effects against atherosclerotic changes in vascular endothelial cells may be partially mediated by the PI3K/Akt/eNOS signaling pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Immunology
Lieve E. H. van der Donk, Louis S. Ates, Jet van der Spek, Laura M. Tukker, Teunis B. H. Geijtenbeek, Jeroen W. J. van Heijst
Summary: The interaction between T-cell antigen receptor (TCR) and its cognate peptide:MHC complexes triggers clustering of TCR:CD3 complexes and subsequent signal transduction. While the classic studies have shown a major role for Src family kinase Lck in TCR downregulation, the extent of this mechanism in primary human T cells remains unclear. Knockdown experiments in primary human T cells revealed redundancy in the contribution of individual tyrosine kinases to TCR downregulation, highlighting the need for further research to understand the complex signaling events controlling TCR downregulation and T cell activation.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Zhenghua Ren, Zhongzheng Lu, Lei Wang, Zeren Huo, Jianhua Cui, Tingting Zheng, Qing Dai, Cuiling Chen, Mengying Qin, Meihua Chen, Rirong Yang
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2015)
Article
Immunology
Shaochun Yuan, Tingting Zheng, Peiyi Li, Rirong Yang, Jie Ruan, Shengfeng Huang, Zhenxin Wu, Anlong Xu
JOURNAL OF IMMUNOLOGY
(2015)
Article
Immunology
Jian Peng, Xin Tao, Rui Li, Jingru Hu, Jie Ruan, Ruihua Wang, Manyi Yang, Rirong Yang, Xiangru Dong, Shangwu Chen, Anlong Xu, Shaochun Yuan
JOURNAL OF IMMUNOLOGY
(2015)
Article
Medicine, General & Internal
Zhe Guo, Jing-Hang Jiang, Jun Zhang, Hao-Jie Yang, Fu-Quan Yang, Ya-Peng Qi, Yan-Ping Zhong, Jie Su, Ri-Rong Yang, Le-Qun Li, Bang-De Xiang
Article
Gastroenterology & Hepatology
Jing-Hang Jiang, Zhe Guo, Hao-Feng Lu, Xiao-Bo Wang, Hao-Jie Yang, Fu-Quan Yang, Si-Yang Bao, Jian-Hong Zhong, Le-Qun Li, Ri-Rong Yang, Bang-De Xiang
WORLD JOURNAL OF GASTROENTEROLOGY
(2015)
Article
Oncology
Jinghang Jiang, Peipei Yang, Zhe Guo, Rirong Yang, Haojie Yang, Fuquan Yang, Lequn Li, Bangde Xiang
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2016)
Article
Oncology
Zhe Guo, Jing-Hang Jiang, Jun Zhang, Hao-Jie Yang, Yan-Ping Zhong, Jie Su, Ri-Rong Yang, Le-Qun Li, Bang-De Xiang
Article
Oncology
Shicong Tang, Hong Pan, Wei Wei, Huawei Yang, Jianlun Liu, Rirong Yang
Article
Oncology
Shicong Tang, Rirong Yang, Xin Zhou, Hong Pan, Jianlun Liu
Review
Immunology
Yingting Zhang, Ryan Springfield, Siyang Chen, Xin Li, Xiaotian Feng, Rosa Moshirian, Rirong Yang, Weiming Yuan
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Urology & Nephrology
Zhenyuan Yu, Jinling Liao, Yang Chen, Chunlin Zou, Haiying Zhang, Jiwen Cheng, Deyun Liu, Tianyu Li, Qingyun Zhang, Jiaping Li, Xiaobo Yang, Yu Ye, Zhiguang Huang, Xinyang Long, Rirong Yang, Zengnan Mo
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2019)
Article
Cell Biology
Rirong Yang, Xiaoli Wang, Deshuang Xi, Jian Mo, Ke Wang, Shunrong Luo, Jiao Wei, Zhenghua Ren, Hui Pang, Yu Luo
Article
Pathology
Bei Zhong, Jun Dong, Rong Zhang, Menghua He, Wuyi Zeng, Jiayi Pan, Jiashan He, Ailin Tao, Rirong Yang, Bishi Fu, Samuel W. French, Hui Liu
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2020)
Article
Oncology
Yun Liu, Wenyu Feng, Yan Dai, Mengying Bao, Zhenchao Yuan, Mingwei He, Zhaojie Qin, Shijie Liao, Juliang He, Qian Huang, Zhenyuan Yu, Yanyu Zeng, Binqian Guo, Rong Huang, Rirong Yang, Yonghua Jiang, Jinling Liao, Zengming Xiao, Xinli Zhan, Chengsen Lin, Jiake Xu, Yu Ye, Jie Ma, Qingjun Wei, Zengnan Mo
Summary: This study identified different cellular subtypes and key transcription factors associated with survival prognosis in osteosarcoma (OS) through single-cell RNA sequencing. Moreover, it revealed the mechanisms by which osteoblastic OS cells regulate osteolysis and angiogenesis, impacting survival prognosis. Furthermore, the study highlighted the potential of immunotherapy targeting CD8(+) T cells and macrophages for OS treatment.
FRONTIERS IN ONCOLOGY
(2021)