Molecular imaging in Alzheimer's disease: new perspectives on biomarkers for early diagnosis and drug development

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Guy M. McKhann et al.   Alzheimers & Dementia

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

(2011) Victor L. Villemagne et al.   ANNALS OF NEUROLOGY

Association Between In Vivo Fluorine 18–Labeled Flutemetamol Amyloid Positron Emission Tomography Imaging and In Vivo Cerebral Cortical Histopathology

(2011) David A. Wolk   ARCHIVES OF NEUROLOGY

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

(2011) M. T. Fodero-Tavoletti et al.   BRAIN

In Vivo Human Amyloid Imaging

(2011) J. Sojkova et al.   Current Alzheimer Research

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Clinical amyloid imaging in Alzheimer's disease

(2011) Karl Herholz et al.   LANCET NEUROLOGY

The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core

(2010) William J. Jagust et al.   Alzheimers & Dementia

18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: A phase 2 trial

(2010) Rik Vandenberghe et al.   ANNALS OF NEUROLOGY

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer’s disease

(2010) Ahmadul Kadir et al.   BRAIN

Increased metabolic vulnerability in early-onset Alzheimer’s disease is not related to amyloid burden

(2010) Gil D. Rabinovici et al.   BRAIN

Nicotinic Acetylcholine Receptor Interaction with β -Amyloid: Molecular, Cellular, and Physiological Consequences

(2010) H. Parri et al.   Current Alzheimer Research

High PIB Retention in Alzheimers Disease is an Early Event with Complex Relationship with CSF Biomarkers and Functional Parameters

(2010) A. Forsberg et al.   Current Alzheimer Research

Pittsburgh Compound-B and Alzheimer’s Disease Biomarkers in CSF, Plasma and Urine: An Exploratory Study

(2010) M. Degerman Gunnarsson et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

In Vivo Imaging of Amyloid Deposition in Alzheimer Disease Using the Radioligand 18F-AV-45 (Flobetapir F 18)

(2010) D. F. Wong et al.   JOURNAL OF NUCLEAR MEDICINE

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

(2010) Juha O Rinne et al.   LANCET NEUROLOGY

Alzheimer's disease: clinical trials and drug development

(2010) Francesca Mangialasche et al.   LANCET NEUROLOGY

The use of PET in Alzheimer disease

(2010) Agneta Nordberg et al.   Nature Reviews Neurology

3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects

(2010) Liana G. Apostolova et al.   NEUROBIOLOGY OF AGING

Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease

(2010) Ahmadul Kadir et al.   NEUROBIOLOGY OF AGING

Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy

(2010) Elina Zotova et al.   Alzheimers Research & Therapy

Amyloid imaging in mild cognitive impairment subtypes

(2009) David A. Wolk et al.   ANNALS OF NEUROLOGY

Pittsburgh Compound B Imaging and Prediction of Progression From Cognitive Normality to Symptomatic Alzheimer Disease

(2009) John C. Morris et al.   ARCHIVES OF NEUROLOGY

Carbon 11–Labeled Pittsburgh Compound B and Carbon 11–Labeled (R)-PK11195 Positron Emission Tomographic Imaging in Alzheimer Disease

(2009) Clayton A. Wiley et al.   ARCHIVES OF NEUROLOGY

Beta Amyloid in Alzheimer's Disease: Increased Deposition in Brain Is Reflected in Reduced Concentration in Cerebrospinal Fluid

(2009) Timo Grimmer et al.   BIOLOGICAL PSYCHIATRY

Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease

(2009) Clifford R. Jack et al.   BRAIN

Cerebrospinal fluid tau and ptau181increase with cortical amyloid deposition in cognitively normal individuals: Implications for future clinical trials of Alzheimer's disease

(2009) Anne M. Fagan et al.   EMBO Molecular Medicine

Activated astrocytes: a therapeutic target in Alzheimer’s disease?

(2009) Stacey Fuller et al.   Expert Review of Neurotherapeutics

Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer’s disease pathologies

(2009) Paul W. Thompson et al.   JOURNAL OF NEUROCHEMISTRY

Relationship of Cerebrospinal Fluid Markers to 11C-PiB and 18F-FDDNP Binding

(2009) N. Tolboom et al.   JOURNAL OF NUCLEAR MEDICINE

Comparison of 18F-FDG and PiB PET in Cognitive Impairment

(2009) V. J. Lowe et al.   JOURNAL OF NUCLEAR MEDICINE

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls

(2009) N. M. Scheinin et al.   NEUROLOGY

Relationships between biomarkers in aging and dementia

(2009) W. J. Jagust et al.   NEUROLOGY

Conversion of amyloid positive and negative MCI to AD over 3 years: An 11C-PIB PET study

(2009) A. Okello et al.   NEUROLOGY

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Cognitive reserve☆

(2009) Yaakov Stern   NEUROPSYCHOLOGIA

Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease

(2008) Ahmadul Kadir et al.   ANNALS OF NEUROLOGY

Assessment of β-Amyloid in a Frontal Cortical Brain Biopsy Specimen and by Positron Emission Tomography With Carbon 11–Labeled Pittsburgh Compound B

(2008) Ville Leinonen   ARCHIVES OF NEUROLOGY

Increased Binding of Peripheral Benzodiazepine Receptor in Alzheimer's Disease Measured by Positron Emission Tomography with [11C]DAA1106

(2008) Fumihiko Yasuno et al.   BIOLOGICAL PSYCHIATRY

Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease

(2008) Milos D. Ikonomovic et al.   BRAIN

PET Amyloid Ligand [11C]PIB Uptake and Cerebrospinal Fluid β-Amyloid in Mild Cognitive Impairment

(2008) J. Koivunen et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Neuropathology and Cognitive Impairment in Alzheimer Disease: A Complex but Coherent Relationship

(2008) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Imaging of amyloid β in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism

(2008) Christopher C Rowe et al.   LANCET NEUROLOGY

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

[11C]PIB-amyloid binding and levels of Aβ40 and Aβ42 in postmortem brain tissue from Alzheimer patients

(2008) Marie M. Svedberg et al.   NEUROCHEMISTRY INTERNATIONAL

PET imaging of amyloid deposition in patients with mild cognitive impairment

(2007) Anton Forsberg et al.   NEUROBIOLOGY OF AGING

Inhibition of acetylcholinesterase in CSF versus brain assessed by 11C-PMP PET in AD patients treated with galantamine

(2006) T. Darreh-Shori et al.   NEUROBIOLOGY OF AGING