Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

Elucidating the Triggers, Progression, and Effects of Alzheimer's Disease

(2018) Rodrigo Medeiros et al.   JOURNAL OF ALZHEIMERS DISEASE

Evolutional Aspects of Alzheimer's Disease Pathogenesis

(2018) Heiko Braak et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptotoxic Amyloid-β Oligomers: A Molecular Basis for the Cause, Diagnosis, and Treatment of Alzheimer's Disease?

(2018) William L. Klein   JOURNAL OF ALZHEIMERS DISEASE

TOC1: Characterization of a Selective Oligomeric Tau Antibody

(2018) Sarah M. Ward et al.   JOURNAL OF ALZHEIMERS DISEASE

Sources of Extracellular Tau and its Signaling

(2018) Jesús Avila et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential Incorporation of Tau Isoforms in Alzheimer's Disease

(2017) Marisol Espinoza et al.   JOURNAL OF ALZHEIMERS DISEASE

Lithium Treatment Arrests the Development of Neurofibrillary Tangles in Mutant Tau Transgenic Mice with Advanced Neurofibrillary Pathology

(2017) Karelle Leroy et al.   JOURNAL OF ALZHEIMERS DISEASE

PP2A Regulates Tau Phosphorylation Directly and also Indirectly via Activating GSK-3β

(2017) Wei Qian et al.   JOURNAL OF ALZHEIMERS DISEASE

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Calcium-Sensing Receptors of Human Neural Cells Play Crucial Roles in Alzheimer's Disease

(2016) Anna Chiarini et al.   Frontiers in Physiology

Molecular Mechanisms of Amyloid Oligomers Toxicity

(2016) Rakez Kayed et al.   JOURNAL OF ALZHEIMERS DISEASE

Calcimimetic and Calcilytic Drugs: Feats, Flops, and Futures

(2015) E. F. Nemeth et al.   CALCIFIED TISSUE INTERNATIONAL

Preventing the Spread of Alzheimer’s Disease Neuropathology: A Role for Calcilytics?

(2015) Anna Chiarini et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Calcium-Sensing Receptors of Human Astrocyte-Neuron Teams: Amyloid-β-Driven Mediators and Therapeutic Targets of Alzheimer’s Disease

(2014) I. Pra et al.   Current Neuropharmacology

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

The Aβ Peptides-Activated Calcium-Sensing Receptor Stimulates the Production and Secretion of Vascular Endothelial Growth Factor-A by Normoxic Adult Human Cortical Astrocytes

(2014) Ilaria Dal Prà et al.   NEUROMOLECULAR MEDICINE

Do Astrocytes Collaborate with Neurons in Spreading the “Infectious” Aβ and Tau Drivers of Alzheimer’s Disease?

(2014) Ilaria Dal Prà et al.   NEUROSCIENTIST

Intraneuronal tau aggregation precedes diffuse plaque deposition, but amyloid-β changes occur before increases of tau in cerebrospinal fluid

(2013) Heiko Braak et al.   ACTA NEUROPATHOLOGICA

The intersection of amyloid beta and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease

(2013) Johanna L. Crimins et al.   AGEING RESEARCH REVIEWS

Calcium-sensing receptor antagonist (calcilytic) NPS 2143 specifically blocks the increased secretion of endogenous Aβ42 prompted by exogenous fibrillary or soluble Aβ25–35 in human cortical astrocytes and neurons—Therapeutic relevance to Alzheimer's disease

(2013) Ubaldo Armato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

“Prion-Like” Templated Misfolding in Tauopathies

(2013) Florence Clavaguera et al.   BRAIN PATHOLOGY

Prostate-derived Sterile 20-like Kinases (PSKs/TAOKs) Phosphorylate Tau Protein and Are Activated in Tangle-bearing Neurons in Alzheimer Disease

(2013) Ignatius A. Tavares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Astrocytes and the evolution of the human brain

(2013) James M. Robertson   MEDICAL HYPOTHESES

Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease

(2013) Usman A Khan et al.   NATURE NEUROSCIENCE

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation and Propagation of Tau Oligomeric Seeds

(2013) Julia E. Gerson et al.   Frontiers in Neurology

The relationship between subcortical tau pathology and Alzheimer's disease

(2012) Johannes Attems et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The neurobiology of Alzheimer disease defined by neuroimaging

(2012) Joseph C. Masdeu et al.   CURRENT OPINION IN NEUROLOGY

Where, when, and in what form does sporadic Alzheimerʼs disease begin?

(2012) Heiko Braak et al.   CURRENT OPINION IN NEUROLOGY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

(2012) Cristian A. Lasagna-Reeves et al.   Scientific Reports

Hyperphosphorylated tau in young and middle-aged subjects

(2011) Adila Elobeid et al.   ACTA NEUROPATHOLOGICA

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Controlled Cortical Impact Traumatic Brain Injury in 3xTg-AD Mice Causes Acute Intra-Axonal Amyloid-  Accumulation and Independently Accelerates the Development of Tau Abnormalities

(2011) H. T. Tran et al.   JOURNAL OF NEUROSCIENCE

Functional implications of the association of tau with the plasma membrane

(2010) Amy M. Pooler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

Selective Vulnerability of Neurons in Layer II of the Entorhinal Cortex during Aging and Alzheimer's Disease

(2010) Alexis M. Stranahan et al.   NEURAL PLASTICITY

The role of tau in neurodegeneration

(2009) Tania F Gendron et al.   Molecular Neurodegeneration

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset?

(2009) L. T. Grinberg et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Biochemistry of Tau in Alzheimer’s disease and related neurological disorders

(2008) Nicolas Sergeant et al.   Expert Review of Proteomics

The amino terminus of tau inhibits kinesin-dependent axonal transport: Implications for filament toxicity

(2008) Nichole E. LaPointe et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death

(2003) Darren A. E. Cross et al.   JOURNAL OF NEUROCHEMISTRY