Inhibitory pattern recognition receptors

Bacterial protein domains with a novel Ig‐like fold target human CEACAM receptors

(2021) Nina M van Sorge et al.   EMBO JOURNAL

Coping with sterile inflammation: between risk and necessity

(2021) DiyaaElDin Ashour et al.   CARDIOVASCULAR RESEARCH

Small RNAs are modified with N-glycans and displayed on the surface of living cells

(2021) Ryan A. Flynn et al.   CELL

CD1a selectively captures endogenous cellular lipids that broadly block T cell response

(2021) Rachel N. Cotton et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recognition of S100 proteins by Signal Inhibitory Receptor on Leukocytes‐1 negatively regulates human neutrophils

(2021) Matevž Rumpret et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Signal inhibitory receptor on leukocytes‐1 recognizes bacterial and endogenous amphipathic α‐helical peptides

(2021) Matevž Rumpret et al.   FASEB JOURNAL

Sialoglycans and Siglecs Can Shape the Tumor Immune Microenvironment

(2020) Stephanie van de Wall et al.   TRENDS IN IMMUNOLOGY

Leukocyte Immunoglobulin-Like Receptors (LILRs) on Human Neutrophils: Modulators of Infection and Immunity

(2020) Alexander L. Lewis Marffy et al.   Frontiers in Immunology

CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells

(2020) Matthias Braun et al.   IMMUNITY

Emerging connectivity of programmed cell death pathways and its physiological implications

(2020) Sammy Bedoui et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolism-Associated Molecular Patterns (MAMPs)

(2020) Xu Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

(2020) David H. Peng et al.   Nature Communications

Not by structures alone: Can the immune system recognize microbial functions?

(2020) Gregor P. Greslehner   Studies in History and Philosophy of Science Part C-Studies in History and Philosophy of Biological and Biomedical Sciences

Dying under pressure: cellular characterisation and in vivo functions of cell death induced by compaction

(2019) Léo Valon et al.   BIOLOGY OF THE CELL

Fusobacterium nucleatum supresses anti-tumor immunity by activating CEACAM1

(2019) Chamutal Gur et al.   OncoImmunology

Fusobacterium spp. target human CEACAM1 via the trimeric autotransporter adhesin CbpF

(2019) Matthew L. Brewer et al.   Journal of Oral Microbiology

The immunoreceptor CD300a controls the intensity of inflammation and dysfunction in a model of Ag‐induced arthritis in mice

(2019) Bruno V. S. Valiate et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanical stress-induced cell death in breast cancer cells

(2019) Satomi Takao et al.   Biology Open

LAIR-1 Limits Neutrophilic Airway Inflammation

(2019) Kuldeep Kumawat et al.   Frontiers in Immunology

Uremic toxins are conditional danger- or homeostasis-associated molecular patterns

(2018) Rongshan Li   Frontiers in Bioscience-Landmark

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Expression of Siglec-8 is regulated by interleukin-5, and serum levels of soluble Siglec-8 may predict responsiveness of severe eosinophilic asthma to mepolizumab

(2018) Sayaka Arakawa et al.   ALLERGOLOGY INTERNATIONAL

Macrophage Clearance of Apoptotic Cells: A Critical Assessment

(2018) Siamon Gordon et al.   Frontiers in Immunology

Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient

(2018) Mickael Vourc’h et al.   Frontiers in Immunology

Pyroptosis versus necroptosis: similarities, differences, and crosstalk

(2018) Daniel Frank et al.   CELL DEATH AND DIFFERENTIATION

Viewing Siglecs through the lens of tumor immunology

(2017) Isabella Fraschilla et al.   IMMUNOLOGICAL REVIEWS

TIGIT and CD96: new checkpoint receptor targets for cancer immunotherapy

(2017) William C. Dougall et al.   IMMUNOLOGICAL REVIEWS

Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j

(2017) Sol Y. Nuñez et al.   JOURNAL OF IMMUNOLOGY

Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells

(2017) Esther Klaile et al.   mBio

IL-35, as a newly proposed homeostasis-associated molecular pattern, plays three major functions including anti-inflammatory initiator, effector, and blocker in cardiovascular diseases

(2017) Xinyuan Li et al.   CYTOKINE

Collagen binding to OSCAR: the odd couple

(2016) B. An et al.   BLOOD

OSCAR-collagen signaling in monocytes plays a proinflammatory role and may contribute to the pathogenesis of rheumatoid arthritis

(2016) Heidi S. Schultz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Carcinoembryonic antigen related cellular adhesion molecule 1 alleviates dextran sulfate sodium-induced ulcerative colitis in mice

(2016) Yu Jin et al.   LIFE SCIENCES

Lysophospholipid Receptors, as Novel Conditional Danger Receptors and Homeostatic Receptors Modulate Inflammation—Novel Paradigm and Therapeutic Potential

(2016) Xin Wang et al.   Journal of Cardiovascular Translational Research

Allele-specific recognition by LILRB3 and LILRA6 of a cytokeratin 8 - associated ligand on necrotic glandular epithelial cells

(2016) Des C. Jones et al.   Oncotarget

Helicobacter pylori exploits human CEACAMs via HopQ for adherence and translocation of CagA

(2016) Verena Königer et al.   Nature Microbiology

Immunomodulatory activity of extracellular Hsp70 mediated via paired receptors Siglec-5 and Siglec-14

(2015) J. J. Fong et al.   EMBO JOURNAL

Binding of the Fap2 Protein of Fusobacterium nucleatum to Human Inhibitory Receptor TIGIT Protects Tumors from Immune Cell Attack

(2015) Chamutal Gur et al.   IMMUNITY

The Biology and Disease Relevance of CD300a, an Inhibitory Receptor for Phosphatidylserine and Phosphatidylethanolamine

(2015) Olatz Zenarruzabeitia et al.   JOURNAL OF IMMUNOLOGY

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

An Apoptotic ‘Eat Me’ Signal: Phosphatidylserine Exposure

(2015) Katsumori Segawa et al.   TRENDS IN CELL BIOLOGY

Bacterial Immune Evasion through Manipulation of Host Inhibitory Immune Signaling

(2015) Kristof Van Avondt et al.   PLoS Pathogens

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

CEACAM1 regulates TIM-3-mediated tolerance and exhaustion

(2014) Yu-Hwa Huang et al.   NATURE

Group B Streptococcus Engages an Inhibitory Siglec through Sialic Acid Mimicry to Blunt Innate Immune and Inflammatory Responses In Vivo

(2014) Yung-Chi Chang et al.   PLoS Pathogens

Induction of Siglec-G by RNA Viruses Inhibits the Innate Immune Response by Promoting RIG-I Degradation

(2013) Weilin Chen et al.   CELL

TLR2 and TLR4 in Autoimmune Diseases: a Comprehensive Review

(2013) Yu Liu et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Signal inhibitory receptor on leukocytes-1 (SIRL-1) negatively regulates the oxidative burst in human phagocytes

(2013) Tessa A. M. Steevels et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

S100A9 protein is a novel ligand for the CD85j receptor and its interaction is implicated in the control of HIV-1 replication by NK cells

(2013) Vincent Arnold et al.   Retrovirology

Human CD300a binds to phosphatidylethanolamine and phosphatidylserine, and modulates the phagocytosis of dead cells

(2012) V. R. Simhadri et al.   BLOOD

Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor

(2012) Chigusa Nakahashi-Oda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibitory Receptor Paired Ig-like Receptor B Is Exploited by Staphylococcus aureus for Virulence

(2012) M. Nakayama et al.   JOURNAL OF IMMUNOLOGY

Balancing pro- and anti-inflammatory TLR4 signaling

(2012) Sabine Siegemund et al.   NATURE IMMUNOLOGY

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Defining the subcellular sites of innate immune signal transduction

(2012) Jonathan C. Kagan   TRENDS IN IMMUNOLOGY

The danger theory: 20 years later

(2012) Thomas Pradeu et al.   Frontiers in Immunology

Resolution-associated molecular patterns (RAMP): RAMParts defending immunological homeostasis?

(2011) A. M. Shields et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Epitope mapping, expression and post-translational modifications of two isoforms of CD33 (CD33M and CD33m) on lymphoid and myeloid human cells

(2011) A. B. Perez-Oliva et al.   GLYCOBIOLOGY

OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice

(2011) Alexander David Barrow et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Mouse CD300f (CMRF-35-Like Molecule-1) Recognizes Outer Membrane-Exposed Phosphatidylserine and Can Promote Phagocytosis

(2011) S.-C. Choi et al.   JOURNAL OF IMMUNOLOGY

Systemic features of immune recognition in the gut

(2011) Bartlomiej Swiatczak et al.   MICROBES AND INFECTION

Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR-1

(2011) Tomasz P. Rygiel et al.   MOLECULAR IMMUNOLOGY

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

(2011) Guo-Yun Chen et al.   NATURE BIOTECHNOLOGY

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Human Formyl Peptide Receptor 2 Senses Highly Pathogenic Staphylococcus aureus

(2010) Dorothee Kretschmer et al.   Cell Host & Microbe

Find-me and eat-me signals in apoptotic cell clearance: progress and conundrums

(2010) Kodi S. Ravichandran   JOURNAL OF EXPERIMENTAL MEDICINE

CD22 x Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity

(2010) J. Jellusova et al.   JOURNAL OF IMMUNOLOGY

Approaching the Asymptote: 20 Years Later

(2009) Ruslan Medzhitov   IMMUNITY

Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III

(2009) Robert Jan Lebbink et al.   MATRIX BIOLOGY

IMMUNOLOGY: Dangers In and Out

(2009) M. E. Bianchi et al.   SCIENCE

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

CD300a/c regulate type I interferon and TNF-  secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands

(2008) X. Ju et al.   BLOOD

The Moraxella adhesin UspA1 binds to its human CEACAM1 receptor by a deformable trimeric coiled-coil

(2008) Rebecca Conners et al.   EMBO JOURNAL

Negative signaling by inhibitory receptors: the NK cell paradigm

(2008) Eric O. Long   IMMUNOLOGICAL REVIEWS

The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells

(2008) Xin Yu et al.   NATURE IMMUNOLOGY

The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells

(2007) N. T. Young et al.   BLOOD

The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcγRIIa) mediated signaling

(2007) Yelina Alvarez et al.   MOLECULAR IMMUNOLOGY