Small RNAs are modified with N-glycans and displayed on the surface of living cells

Siglecs as Immune Cell Checkpoints in Disease

(2020) Shiteng Duan et al.   Annual Review of Immunology

Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells

(2020) Benjamin Schumann et al.   MOLECULAR CELL

Targeted glycan degradation potentiates the anticancer immune response in vivo

(2020) Melissa A. Gray et al.   Nature Chemical Biology

The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins

(2019) Stacy A. Malaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosylation in health and disease

(2019) Colin Reily et al.   Nature Reviews Nephrology

Ro60 and Y RNAs: structure, functions, and roles in autoimmunity

(2019) Marco Boccitto et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx

(2019) Leonhard Möckl et al.   DEVELOPMENTAL CELL

SIDT1 Localizes to Endolysosomes and Mediates Double-Stranded RNA Transport into the Cytoplasm

(2019) Tan A. Nguyen et al.   JOURNAL OF IMMUNOLOGY

Expanding APEX2 Substrates for Proximity-Dependent Labeling of Nucleic Acids and Proteins in Living Cells

(2019) Ying Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Atlas of Subcellular RNA Localization Revealed by APEX-Seq

(2019) Furqan M. Fazal et al.   CELL

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy

(2019) Amira A. Barkal et al.   NATURE

Artificial Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling

(2018) Wei Qin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Siglec genes confer resistance to systemic lupus erythematosus in humans and mice

(2018) Rhonda Flores et al.   Cellular & Molecular Immunology

Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells

(2018) Michal A. Stanczak et al.   JOURNAL OF CLINICAL INVESTIGATION

Biological functions of fucose in mammals

(2017) Michael Schneider et al.   GLYCOBIOLOGY

Viewing Siglecs through the lens of tumor immunology

(2017) Isabella Fraschilla et al.   IMMUNOLOGICAL REVIEWS

Biotinylation by antibody recognition—a method for proximity labeling

(2017) Daniel Z Bar et al.   NATURE METHODS

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

Lysosomal putative RNA transporter SIDT2 mediates direct uptake of RNA by lysosomes

(2016) Shu Aizawa et al.   Autophagy

The Muscular Dystrophy GeneTMEM5Encodes a Ribitol β1,4-Xylosyltransferase Required for the Functional Glycosylation of Dystroglycan

(2016) Hiroshi Manya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells

(2016) Cecilia Lopez-Sambrooks et al.   Nature Chemical Biology

irCLIP platform for efficient characterization of protein–RNA interactions

(2016) Brian J Zarnegar et al.   NATURE METHODS

Transcriptome-wide interrogation of RNA secondary structure in living cells with icSHAPE

(2016) Ryan A Flynn et al.   Nature Protocols

CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering

(2016) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

Precision glycocalyx editing as a strategy for cancer immunotherapy

(2016) Han Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglec-1 and -2 as potential biomarkers in autoimmune disease

(2016) Amanda J. Eakin et al.   Proteomics Clinical Applications

The emerging biology of RNA post-transcriptional modifications

(2016) Sigrid Nachtergaele et al.   RNA Biology

The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition

(2016) Jeremy L Praissman et al.   eLife

Functional roles of non-coding Y RNAs

(2015) Madzia P. Kowalski et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice

(2015) Jennifer Müller et al.   JOURNAL OF IMMUNOLOGY

Isotope-targeted glycoproteomics (IsoTaG): a mass-independent platform for intact N- and O-glycopeptide discovery and analysis

(2015) Christina M Woo et al.   NATURE METHODS

The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

(2015) Benedikt M. Beckmann et al.   Nature Communications

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

(2014) Thomas R. Cech et al.   CELL

Associations of genetic polymorphisms of Siglecs with human diseases

(2014) Takashi Angata   GLYCOBIOLOGY

Lectin Galactoside-binding Soluble 3 Binding Protein (LGALS3BP) Is a Tumor-associated Immunomodulatory Ligand for CD33-related Siglecs

(2014) Heinz Läubli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading

(2014) Keith T Gagnon et al.   Nature Protocols

Dissecting noncoding and pathogen RNA–protein interactomes

(2014) Ryan A. Flynn et al.   RNA

The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation

(2014) Tobias Willer et al.   eLife

B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan

(2014) Jeremy L Praissman et al.   eLife

Expression of an anti-RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN-I expression

(2013) Jin-Hwan Han et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

SGK196 Is a Glycosylation-Specific O-Mannose Kinase Required for Dystroglycan Function

(2013) T. Yoshida-Moriguchi et al.   SCIENCE

Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

(2013) H.-W. Rhee et al.   SCIENCE

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Autoantibodies associated with RNA are more enriched than anti-dsDNA antibodies in circulating immune complexes in SLE

(2012) E Åhlin et al.   LUPUS

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

Global metabolic inhibitors of sialyl- and fucosyltransferases remodel the glycome

(2012) Cory D Rillahan et al.   Nature Chemical Biology

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

Dystroglycan Function Requires Xylosyl- and Glucuronyltransferase Activities of LARGE

(2012) K.-i. Inamori et al.   SCIENCE

Metabolism of Diazirine-ModifiedN-Acetylmannosamine Analogues to Photo-Cross-Linking Sialosides

(2011) Michelle R. Bond et al.   BIOCONJUGATE CHEMISTRY

Oligosaccharyltransferase: the central enzyme of N-linked protein glycosylation

(2011) Elisabeth Mohorko et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Analysis of antibodies to RNA in patients with systemic lupus erythematosus and other autoimmune rheumatic diseases

(2010) F. BLANCO et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The eight human “canonical” ribonucleases: Molecular diversity, catalytic properties, and special biological actions of the enzyme proteins

(2010) Salvatore Sorrentino   FEBS LETTERS

Metabolic Labeling of Sialic Acids in Living Animals with Alkynyl Sugars

(2009) Pamela V. Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Centrality of RNA

(2009) Phillip A. Sharp   CELL

PD-1 signaling in primary T cells

(2009) James L. Riley   IMMUNOLOGICAL REVIEWS

A conserved motif of vertebrate Y RNAs essential for chromosomal DNA replication

(2009) T. J. Gardiner et al.   RNA

Novel endo- -N-acetylgalactosaminidases with broader substrate specificity

(2008) D. Koutsioulis et al.   GLYCOBIOLOGY

GtRNAdb: a database of transfer RNA genes detected in genomic sequence

(2008) P. P. Chan et al.   NUCLEIC ACIDS RESEARCH