TLR2 and TLR4 in Autoimmune Diseases: a Comprehensive Review

Pathogenesis of type 1 diabetes: lessons from natural history studies of high-risk individuals

(2013) Natalie Nokoff et al.   Annals of the New York Academy of Sciences

Toll-Like Receptors’ Pathway Disturbances are Associated with Increased Susceptibility to Infections in Humans

(2013) Josias Brito Frazão et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Lipopolysaccharide Increases the Incidence of Collagen-Induced Arthritis in Mice Through Induction of Protease HTRA-1 Expression

(2013) Yuzhu Hou et al.   ARTHRITIS AND RHEUMATISM

CD14 and TLR4 mediate cytokine release promoted by electronegative LDL in monocytes

(2013) Montserrat Estruch et al.   ATHEROSCLEROSIS

Procyanidin dimer B2-mediated IRAK-M induction negatively regulates TLR4 signaling in macrophages

(2013) Nak-Yun Sung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of toll-like receptors in systemic sclerosis

(2013) Marzena Ciechomska et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

UXT plays dual opposing roles on SARM-induced apoptosis

(2013) Shalini Sethurathinam et al.   FEBS LETTERS

SHPS-1 and a synthetic peptide representing its ITIM inhibit the MyD88, but not TRIF, pathway of TLR signaling through activation of SHP and PI3K in THP-1 cells

(2013) Eun-Ju Kim et al.   INFLAMMATION RESEARCH

Total coumarins from Urtica dentata Hand prevent murine autoimmune diabetes via suppression of the TLR4-signaling pathways

(2013) Jun Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Autoantibody Induction by DNA-Containing Immune Complexes Requires HMGB1 with the TLR2/MicroRNA-155 Pathway

(2013) Z. Wen et al.   JOURNAL OF IMMUNOLOGY

Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs

(2013) D. Ori et al.   JOURNAL OF IMMUNOLOGY

TRIF-Mediated TLR3 and TLR4 Signaling Is Negatively Regulated by ADAM15

(2013) S. Ahmed et al.   JOURNAL OF IMMUNOLOGY

TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion

(2013) Ying Wang et al.   MEDIATORS OF INFLAMMATION

Molecular control of the NEMO family of ubiquitin-binding proteins

(2013) Kristopher Clark et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Surface expression and genotypes of Toll-like receptors 2 and 4 in patients with juvenile idiopathic arthritis and systemic lupus erythematosus

(2013) Martina Kirchner et al.   Pediatric Rheumatology

Toll-like receptors as therapeutic targets for autoimmune connective tissue diseases

(2013) Jing Li et al.   PHARMACOLOGY & THERAPEUTICS

Celastrol Inhibits Lipopolysaccharide-Stimulated Rheumatoid Fibroblast-Like Synoviocyte Invasion through Suppression of TLR4/NF-κB-Mediated Matrix Metalloproteinase-9 Expression

(2013) Guoqing Li et al.   PLoS One

E3 ligase WWP2 negatively regulates TLR3-mediated innate immune response by targeting TRIF for ubiquitination and degradation

(2013) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of high mobility group box chromosomal protein 1 in rheumatoid arthritis

(2013) Yu Chen et al.   RHEUMATOLOGY

Ubiquitin-Specific Protease 25 Regulates TLR4-Dependent Innate Immune Responses Through Deubiquitination of the Adaptor Protein TRAF3

(2013) B. Zhong et al.   Science Signaling

Bacterial lipopolysaccharides form procollagen-endotoxin complexes that trigger cartilage inflammation and degeneration: implications for the development of rheumatoid arthritis

(2013) Wolfgang Lorenz et al.   ARTHRITIS RESEARCH & THERAPY

Review of the pharmacoeconomics of early treatment of multiple sclerosis using interferon beta

(2013) Florian Castrop et al.   Neuropsychiatric Disease and Treatment

Reprogramming of Murine Macrophages through TLR2 Confers Viral Resistance via TRAF3-Mediated, Enhanced Interferon Production

(2013) Darren J. Perkins et al.   PLoS Pathogens

The Interferon-Signature of Sjögren’s Syndrome: How Unique Biomarkers Can Identify Underlying Inflammatory and Immunopathological Mechanisms of Specific Diseases

(2013) Cuong Quoc Nguyen et al.   Frontiers in Immunology

Toll-Like Receptor 4 Signaling Augments Transforming Growth Factor-β Responses

(2012) Swati Bhattacharyya et al.   AMERICAN JOURNAL OF PATHOLOGY

TLR4 regulates cardiac lipid accumulation and diabetic heart disease in the nonobese diabetic mouse model of type 1 diabetes

(2012) Baojun Dong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Regulation of Toll-like receptor signaling pathways in innate immune responses

(2012) Cheng Qian et al.   Annals of the New York Academy of Sciences

SNAPIN: an endogenous toll-like receptor ligand in rheumatoid arthritis

(2012) Bo Shi et al.   ANNALS OF THE RHEUMATIC DISEASES

Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis

(2012) Qi-Quan Huang et al.   ARTHRITIS AND RHEUMATISM

Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis

(2012) Patrizia Fuschiotti et al.   ARTHRITIS AND RHEUMATISM

Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes

(2012) Giuseppe M. Campo et al.   BIOFACTORS

Adaptors in Toll-Like Receptor Signaling and their Potential as Therapeutic Targets

(2012) Thomas Ve et al.   CURRENT DRUG TARGETS

Toll-like receptor 4 on islet β cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes

(2012) Min Li et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Pathogenesis of lupus-like nephritis through autoimmune antibody produced by CD180-negative B lymphocytes in NZBWF1 mouse

(2012) Kazuko Fujita et al.   IMMUNOLOGY LETTERS

Lack of association of TLR4 polymorphisms with susceptibility to rheumatoid arthritis and ankylosing spondylitis: A meta-analysis

(2012) Wang-Dong Xu et al.   JOINT BONE SPINE

Structural Analyses of Human Toll-like Receptor 4 Polymorphisms D299G and T399I

(2012) Umeharu Ohto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1

(2012) Meng Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNAs and Toll-like Receptor/Interleukin-1 Receptor Signaling

(2012) Anthony Virtue et al.   Journal of Hematology & Oncology

Gadolinium Compounds Signaling through TLR 4 and TLR 7 in Normal Human Macrophages: Establishment of a Proinflammatory Phenotype and Implications for the Pathogenesis of Nephrogenic Systemic Fibrosis

(2012) P. J. Wermuth et al.   JOURNAL OF IMMUNOLOGY

Leishmania donovani Exploits Host Deubiquitinating Enzyme A20, a Negative Regulator of TLR Signaling, To Subvert Host Immune Response

(2012) S. Srivastav et al.   JOURNAL OF IMMUNOLOGY

PINK1 positively regulates IL-1β-mediated signaling through Tollip and IRAK1 modulation

(2012) Hyun Jung Lee et al.   Journal of Neuroinflammation

Systemic Lupus Erythematosus

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation

(2012) J. M. Reynolds et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population

(2012) Hongju Yang et al.   RHEUMATOLOGY INTERNATIONAL

HMGB1 Promotes the Differentiation of Th17 via Up-Regulating TLR2 and IL-23 of CD14+Monocytes from Patients with Rheumatoid Arthritis

(2012) Z. He et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

TLR2 ligation induces the production of IL-23/IL-17 via IL-6, STAT3 and NF-kB pathway in patients with primary Sjogren's syndrome

(2012) Seung-Ki Kwok et al.   ARTHRITIS RESEARCH & THERAPY

Implication of the toll-like receptor 4 pathway in the response to interferon-β in multiple sclerosis

(2011) Marta F. Bustamante et al.   ANNALS OF NEUROLOGY

Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy

(2011) Sridevi Devaraj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study

(2011) Marieke Emonts et al.   BMC Medical Genetics

Altered IL-10 and TNF-α production in peripheral blood mononuclear cells of systemic lupus erythematosus patients after Toll-like receptor 2, 4, or 9 activation

(2011) Jeng-Ting Tsao et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or I B  Deficiency

(2011) C. Picard et al.   CLINICAL MICROBIOLOGY REVIEWS

Activation of the type I interferon pathway in primary Sjögrenʼs syndrome

(2011) Katerina M. Vakaloglou et al.   CURRENT OPINION IN RHEUMATOLOGY

Knockout of toll-like receptor-4 attenuates the pro-inflammatory state of diabetes

(2011) Sridevi Devaraj et al.   CYTOKINE

Role of TLR2 in the pathogenesis of autoimmune diabetes and its therapeutic implication

(2011) Myung-Shik Lee et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

TLR2 signaling improves immunoregulation to prevent type 1 diabetes

(2011) Christophe M. Filippi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Signaling via the RIP2 Adaptor Protein in Central Nervous System-Infiltrating Dendritic Cells Promotes Inflammation and Autoimmunity

(2011) Patrick J. Shaw et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

CD300a and CD300f differentially regulate the MyD88 and TRIF-mediated TLR signalling pathways through activation of SHP-1 and/or SHP-2 in human monocytic cell lines

(2011) Eun-Ju Kim et al.   IMMUNOLOGY

Inhibition of Autoimmune Diabetes by TLR2 Tolerance

(2011) Do-Hoon Kim et al.   JOURNAL OF IMMUNOLOGY

Increased gene expression of Toll-like receptor 4 on peripheral blood mononuclear cells in patients with psoriasis

(2011) S. Garcia-Rodriguez et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Increased TLR2 expression in patients with type 1 diabetes: evidenced risk of microalbuminuria

(2011) Marcela Abbott Galvão Ururahy et al.   PEDIATRIC DIABETES

Toll-Like Receptor 4 Is Involved in Inflammatory and Joint Destructive Pathways in Collagen-Induced Arthritis in DBA1J Mice

(2011) Matthias Pierer et al.   PLoS One

Toll-Like Receptor 2 Induced Angiogenesis and Invasion Is Mediated through the Tie2 Signalling Pathway in Rheumatoid Arthritis

(2011) Tajvur Saber et al.   PLoS One

Toll-like receptor 4 signalling is specifically TGF-beta-activated kinase 1 independent in synovial fibroblasts

(2011) Jeroen Geurts et al.   RHEUMATOLOGY

Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis

(2011) F. G. Goh et al.   RHEUMATOLOGY

The Structural Biology of Toll-like Receptors

(2011) Istvan Botos et al.   STRUCTURE

Intrinsic and Extrinsic Regulation of Innate Immune Receptors

(2011) Eunshil Jeong et al.   YONSEI MEDICAL JOURNAL

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

(2011) Heidi Wähämaa et al.   ARTHRITIS RESEARCH & THERAPY

Distinct evolution of TLR-mediated dendritic cell cytokine secretion in patients with limited and diffuse cutaneous systemic sclerosis

(2010) L. van Bon et al.   ANNALS OF THE RHEUMATIC DISEASES

Lipoteichoic acid enhances IL-6 production in human synovial fibroblasts via TLR2 receptor, PKCδ and c-Src dependent pathways

(2010) Chih-Hsin Tang et al.   BIOCHEMICAL PHARMACOLOGY

Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

(2010) A. Komatsuda et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toll-like receptors regulate B cell cytokine production in patients with diabetes

(2010) M. Jagannathan et al.   DIABETOLOGIA

Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine?

(2010) Emmanuel Lorne et al.   INTENSIVE CARE MEDICINE

Role for toll-like receptors in autoimmune disease: The example of systemic lupus erythematosus

(2010) Christophe Richez et al.   JOINT BONE SPINE

TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy

(2010) S.A. Summers et al.   JOURNAL OF AUTOIMMUNITY

Transgenic overexpression of anti-double-stranded DNA autoantibody and activation of Toll-like receptor 4 in mice induce severe systemic lupus erythematosus syndromes

(2010) Tai-Ping Lee et al.   JOURNAL OF AUTOIMMUNITY

The proteoglycan biglycan regulates expression of the B cell chemoattractant CXCL13 and aggravates murine lupus nephritis

(2010) Kristin Moreth et al.   JOURNAL OF CLINICAL INVESTIGATION

TLR-signaling Networks

(2010) J. Brown et al.   JOURNAL OF DENTAL RESEARCH

Demonstration of increased toll-like receptor 2 and toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications

(2010) Sridevi Devaraj et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

Hyaluronan blocks oligodendrocyte progenitor maturation and remyelination through TLR2

(2010) J. A. Sloane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rheumatoid arthritis progression mediated by activated synovial fibroblasts

(2010) Elena Neumann et al.   TRENDS IN MOLECULAR MEDICINE

The Role of Toll-Like Receptor Pathways in the Mechanism of Type 1 Diabetes

(2009) Egil Lien et al.   CURRENT MOLECULAR MEDICINE

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

Critical Role of TLR2 and TLR4 in Autoantibody Production and Glomerulonephritis in lpr Mutation-Induced Mouse Lupus

(2009) A. Lartigue et al.   JOURNAL OF IMMUNOLOGY

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Enhanced interleukin‐10 production by dendritic cells upon stimulation with Toll‐like receptor 4 agonists in systemic sclerosis that is possibly implicated in CCL18 secretion

(2009) A. W. T. van Lieshout et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

(2009) Peyman Nakhaei et al.   PLoS Pathogens

The role of Toll-like receptors in rheumatoid arthritis

(2009) Qi-Quan Huang et al.   Current Rheumatology Reports

CD19 Regulates Skin and Lung Fibrosis via Toll-Like Receptor Signaling in a Model of Bleomycin-Induced Scleroderma

(2008) Ayumi Yoshizaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Antifibroblast antibodies in systemic sclerosis induce fibroblasts to produce profibrotic chemokines, with partial exploitation of toll-like receptor 4

(2008) Serena Fineschi et al.   ARTHRITIS AND RHEUMATISM

Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: Toll-like receptor expression in early and longstanding arthritis

(2008) Caroline Ospelt et al.   ARTHRITIS AND RHEUMATISM

TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus

(2008) John Castiblanco et al.   INFECTION GENETICS AND EVOLUTION

Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis

(2008) Shahla Abdollahi-Roodsaz et al.   JOURNAL OF CLINICAL INVESTIGATION

Pivotal Advance: HMGB1 expression in active lesions of human and experimental multiple sclerosis

(2008) Åsa Andersson et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Increased Responsiveness to Toll-Like Receptor 4 Stimulation in Peripheral Blood Mononuclear Cells from Patients with Recent Onset Rheumatoid Arthritis

(2008) M. L. Kowalski et al.   MEDIATORS OF INFLAMMATION

Complications infectieuses au cours du lupus érythémateux systémique : étude de 146 patients

(2008) M. Jallouli et al.   REVUE DE MEDECINE INTERNE