HMGB1 and RAGE in Inflammation and Cancer

Maturing Dendritic Cells Depend on RAGE for In Vivo Homing to Lymph Nodes

(2014) A. A. Manfredi et al.   JOURNAL OF IMMUNOLOGY

Chemotactic Activity of S100A7 (Psoriasin) Is Mediated by the Receptor for Advanced Glycation End Products and Potentiates Inflammation with Highly Homologous but Functionally Distinct S100A15

(2014) R. Wolf et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

(2014) Y. Sha et al.   JOURNAL OF IMMUNOLOGY

High Mobility Group Box 1 Protein Binding to Lipopolysaccharide Facilitates Transfer of Lipopolysaccharide to CD14 and Enhances Lipopolysaccharide-Mediated TNF-  Production in Human Monocytes

(2014) J. H. Youn et al.   JOURNAL OF IMMUNOLOGY

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

(2009) Pamela Gasse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Effect of Polymyxin B-Immobilized Fiber Hemoperfusion on Serum High Mobility Group Box-1 Protein Levels and Oxidative Stress in Patients With Acute Respiratory Distress Syndrome

(2009) Tsukasa Nakamura et al.   ASAIO JOURNAL

High mobility group B2 is secreted by myeloid cells and has mitogenic and chemoattractant activities similar to high mobility group B1

(2009) Tobias Pusterla et al.   AUTOIMMUNITY

The receptor for advanced glycation endproducts (RAGE) and cardiovascular disease

(2009) Shi Fang Yan et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Bacterial Endotoxin Induces the Release of High Mobility Group Box 1 via the IFN-  Signaling Pathway

(2009) J.-H. Kim et al.   JOURNAL OF IMMUNOLOGY

Src family kinases are necessary for cell migration induced by extracellular HMGB1

(2009) Roberta Palumbo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Requirement of HMGB1 for stromal cell-derived factor-1/CXCL12-dependent migration of macrophages and dendritic cells

(2009) Lara Campana et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer

(2009) Hye Chung et al.   Journal of Translational Medicine

RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation

(2009) Louis J Sparvero et al.   Journal of Translational Medicine

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

(2009) Hideyuki Yanai et al.   NATURE

The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1

(2009) C. Cayrol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

HMGB1 IS MARKEDLY ELEVATED WITHIN 6 HOURS OF MECHANICAL TRAUMA IN HUMANS

(2009) Erik D. Peltz et al.   SHOCK

Mechanisms of Toll-Like Receptor 4 (TLR4)-Mediated Inflammation After Cold Ischemia/Reperfusion in the Heart

(2009) David J. Kaczorowski et al.   TRANSPLANTATION

Interleukin-33 – cytokine of dual function or novel alarmin?

(2009) Guttorm Haraldsen et al.   TRENDS IN IMMUNOLOGY

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

(2009) Per Björk et al.   PLOS BIOLOGY

The Role of High Mobility Group Box1 in Pulmonary Fibrosis

(2008) Naoki Hamada et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Receptor for advanced glycation end-products (RAGE) modulates neutrophil adhesion and migration on glycoxidated extracellular matrix

(2008) Fatouma Touré et al.   BIOCHEMICAL JOURNAL

Binding of S100 proteins to RAGE: An update

(2008) Estelle Leclerc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of high-mobility group box 1 protein in post-infarction healing process and left ventricular remodelling

(2008) T. Kohno et al.   CARDIOVASCULAR RESEARCH

A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)

(2008) Angela Raucci et al.   FASEB JOURNAL

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

Pathogenic anti-DNA antibodies modulate gene expression in mesangial cells: Involvement of HMGB1 in anti-DNA antibody-induced renal injury

(2008) Xiaoping Qing et al.   IMMUNOLOGY LETTERS

Interaction of the RAGE Cytoplasmic Domain with Diaphanous-1 Is Required for Ligand-stimulated Cellular Migration through Activation of Rac1 and Cdc42

(2008) Barry I. Hudson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity

(2008) Ayumi Yoshizaki et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis

(2008) George Plitas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Induction of inflammatory and immune responses by HMGB1–nucleosome complexes: implications for the pathogenesis of SLE

(2008) Vilma Urbonaviciute et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Functional roles for C5a receptors in sepsis

(2008) Daniel Rittirsch et al.   NATURE MEDICINE

Systemic TNF blockade does not modulate synovial expression of the pro-inflammatory mediator HMGB1 in rheumatoid arthritis patients – a prospective clinical study

(2008) Erik Sundberg et al.   ARTHRITIS RESEARCH & THERAPY

Induction of arthritis by high mobility group box chromosomal protein 1 is independent of tumour necrosis factor signalling

(2008) Rille Pullerits et al.   ARTHRITIS RESEARCH & THERAPY

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

(2008) David S Pisetsky et al.   ARTHRITIS RESEARCH & THERAPY

Mechanisms of Disease: advanced glycation end-products and their receptor in inflammation and diabetes complications

(2008) Shi Fang Yan et al.   Nature clinical practice. Endocrinology & metabolism

Identification, classification, and expression of RAGE gene splice variants

(2007) Barry I. Hudson et al.   FASEB JOURNAL