Viewing Siglecs through the lens of tumor immunology

Prognostic significance of CD169-positive lymph node sinus macrophages in patients with endometrial carcinoma

(2016) Koji Ohnishi et al.   CANCER SCIENCE

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

The CD169 sialoadhesin molecule mediates cytotoxic T-cell responses to tumour apoptotic vesicles

(2016) Lane VC Black et al.   IMMUNOLOGY AND CELL BIOLOGY

CD169 identifies an anti-tumour macrophage subpopulation in human hepatocellular carcinoma

(2016) Yi Zhang et al.   JOURNAL OF PATHOLOGY

Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia

(2016) Hagop M. Kantarjian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

(2016) Maurizio Perdicchio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

(2016) F. Pucci et al.   SCIENCE

Monoclonal antibodies in acute lymphoblastic leukemia

(2015) E. Jabbour et al.   BLOOD

Sialic acids in cancer biology and immunity

(2015) Oliver M T Pearce et al.   GLYCOBIOLOGY

Mouse Siglec-1 Mediatestrans-Infection of Surface-bound Murine Leukemia Virus in a Sialic AcidN-Acyl Side Chain-dependent Manner

(2015) Elina Erikson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effect of cytokines on Siglec-1 and HIV-1 entry in monocyte-derived macrophages: the importance of HIV-1 envelope V1V2 region

(2015) O. Jobe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

HIV-1 immune activation induces Siglec-1 expression and enhances viral trans-infection in blood and tissue myeloid cells

(2015) Maria Pino et al.   Retrovirology

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection

(2015) X. Sewald et al.   SCIENCE

Prognostic Significance of CD169+ Lymph Node Sinus Macrophages in Patients with Malignant Melanoma

(2015) Y. Saito et al.   Cancer Immunology Research

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Lectin Galactoside-binding Soluble 3 Binding Protein (LGALS3BP) Is a Tumor-associated Immunomodulatory Ligand for CD33-related Siglecs

(2014) Heinz Läubli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions between Siglec-7/9 receptors and ligands influence NK cell–dependent tumor immunosurveillance

(2014) Camilla Jandus et al.   JOURNAL OF CLINICAL INVESTIGATION

Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer

(2014) Heinz Läubli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD169 mediates the capture of exosomes in spleen and lymph node

(2013) S. C. Saunderson et al.   BLOOD

ST6Gal-I Protein Expression Is Upregulated in Human Epithelial Tumors and Correlates with Stem Cell Markers in Normal Tissues and Colon Cancer Cell Lines

(2013) A. F. Swindall et al.   CANCER RESEARCH

CD169-positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma

(2013) Koji Ohnishi et al.   CANCER SCIENCE

Binding of a Sialic Acid-recognizing Lectin Siglec-9 Modulates Adhesion Dynamics of Cancer Cells via Calpain-mediated Protein Degradation

(2013) Ilhamjan Sabit et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding of the Sialic Acid-binding Lectin, Siglec-9, to the Membrane Mucin, MUC1, Induces Recruitment of β-Catenin and Subsequent Cell Growth

(2013) Shuhei Tanida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sialoadhesin Ligand Expression Identifies a Subset of CD4+Foxp3- T Cells with a Distinct Activation and Glycosylation Profile

(2013) D. Kidder et al.   JOURNAL OF IMMUNOLOGY

Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion

(2013) Jason E Hudak et al.   Nature Chemical Biology

T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10

(2013) Esther Bandala-Sanchez et al.   NATURE IMMUNOLOGY

Targeted delivery of lipid antigen to macrophages via the CD169/sialoadhesin endocytic pathway induces robust invariant natural killer T cell activation

(2013) N. Kawasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

Colonic Epithelial Cells Express Specific Ligands for Mucosal Macrophage Immunosuppressive Receptors Siglec-7 and -9

(2012) K. Miyazaki et al.   JOURNAL OF IMMUNOLOGY

Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond

(2012) P. Mark Hogarth et al.   NATURE REVIEWS DRUG DISCOVERY

Antigen Delivery to Macrophages Using Liposomal Nanoparticles Targeting Sialoadhesin/CD169

(2012) Weihsu C. Chen et al.   PLoS One

Engagement of Siglec-7 Receptor Induces a Pro-Inflammatory Response Selectively in Monocytes

(2012) Stefania Varchetta et al.   PLoS One

Sialoadhesin in recognition of self and non-self

(2012) Mariliis Klaas et al.   Seminars in Immunopathology

Plasmacytoid Dendritic Cells Are Crucial for the Initiation of Inflammation and T Cell Immunity In Vivo

(2011) Hideaki Takagi et al.   IMMUNITY

Early Murine T-lymphocyte Activation Is Accompanied by a Switch fromN-Glycolyl- toN-Acetyl-neuraminic Acid and Generation of Ligands for Siglec-E

(2011) Pierre Redelinghuys et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Porcine Sialoadhesin (CD169/Siglec-1) Is an Endocytic Receptor that Allows Targeted Delivery of Toxins and Antigens to Macrophages

(2011) Peter L. Delputte et al.   PLoS One

Immunomodulation of monocyte-derived dendritic cells through ligation of tumor-produced mucins to Siglec-9

(2010) Mariko Ohta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis

(2010) Pauline Andreu et al.   CANCER CELL

Ganglioside DSGb5, preferred ligand for Siglec-7, inhibits NK cell cytotoxicity against renal cell carcinoma cells

(2010) Y. Kawasaki et al.   GLYCOBIOLOGY

CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens

(2010) Kenichi Asano et al.   IMMUNITY

MUC16 provides immune protection by inhibiting synapse formation between NK and ovarian tumor cells

(2010) Jennifer AA Gubbels et al.   Molecular Cancer

Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes

(2010) Jennifer A. Belisle et al.   Molecular Cancer

Sialic acids as regulators of molecular and cellular interactions

(2009) Roland Schauer   CURRENT OPINION IN STRUCTURAL BIOLOGY

Siglec-7 mediates nonapoptotic cell death independently of its immunoreceptor tyrosine-based inhibitory motifs in monocytic cell line U937

(2009) Motoaki Mitsuki et al.   GLYCOBIOLOGY

Sialoadhesin-Positive Macrophages Bind Regulatory T Cells, Negatively Controlling Their Expansion and Autoimmune Disease Progression

(2009) Chuan Wu et al.   JOURNAL OF IMMUNOLOGY

Siglec-9 enhances IL-10 production in macrophages via tyrosine-based motifs

(2008) Munetoshi Ando et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiple changes in sialic acid biology during human evolution

(2008) Ajit Varki   GLYCOCONJUGATE JOURNAL

Humoral Immunity Directed against Tumor-Associated Antigens As Potential Biomarkers for the Early Diagnosis of Cancer

(2008) Hailing Lu et al.   JOURNAL OF PROTEOME RESEARCH

NK cells and cancer immunosurveillance

(2008) I Waldhauer et al.   ONCOGENE

Sialoadhesin Expressed on IFN-Induced Monocytes Binds HIV-1 and Enhances Infectivity

(2008) Hans Rempel et al.   PLoS One

Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression

(2008) M. Hedlund et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA