Balancing pro- and anti-inflammatory TLR4 signaling

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Defining the subcellular sites of innate immune signal transduction

(2012) Jonathan C. Kagan   TRENDS IN IMMUNOLOGY

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

(2011) Jonathan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K  Inhibitors in Cancer: Rationale and Serendipity Merge in the Clinic

(2011) D. A. Fruman et al.   Cancer Discovery

Altered Macrophage Function Contributes to Colitis in Mice Defective in the Phosphoinositide-3 Kinase Subunit p110δ

(2010) Jennifer K. Uno et al.   GASTROENTEROLOGY

Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation

(2010) Philipp Günzl et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Mal connects TLR2 to PI3Kinase activation and phagocyte polarization

(2009) S Santos-Sierra et al.   EMBO JOURNAL

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

(2009) Michelle H. W. Laird et al.   JOURNAL OF LEUKOCYTE BIOLOGY