Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

(2011) T. Madhusudhan et al.   BLOOD

The occupancy of endothelial protein C receptor by its ligand modulates the par-1 dependent signaling specificity of coagulation proteases

(2011) Alireza R. Rezaie   IUBMB LIFE

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc Modulates the Interaction of Protein C and Activated Protein C with Endothelial Cell Protein C Receptor

(2010) Prosenjit Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

(2010) Chunzhang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant

(2009) L. O. Mosnier et al.   BLOOD

Regulation of endothelial protein C receptor shedding by cytokines is mediated through differential activation of MAP kinase signaling pathways

(2009) Mario Menschikowski et al.   EXPERIMENTAL CELL RESEARCH

Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock

(2009) J. XU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular histones are major mediators of death in sepsis

(2009) Jun Xu et al.   NATURE MEDICINE

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Driving Rho GTPase activity in endothelial cells regulates barrier integrity

(2009) C. M. L. Beckers et al.   THROMBOSIS AND HAEMOSTASIS

Protein C supports platelet binding and activation under flow: role of glycoprotein Ib and apolipoprotein E receptor 2

(2008) T. C. WHITE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Lipid raft localization regulates the cleavage specificity of protease activated receptor 1 in endothelial cells

(2008) J.-S. BAE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

(2008) X. V. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA