Phosphoproteomic analysis of protease-activated receptor-1 biased signaling reveals unique modulators of endothelial barrier function

Illuminating the dark phosphoproteome

(2019) Elise J. Needham et al.   Science Signaling

β-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-β in stroke

(2019) Hideaki Kanki et al.   Cell Death & Disease

Activated protein C, protease activated receptor 1, and neuroprotection

(2018) John H. Griffin et al.   BLOOD

A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling

(2018) Neil J. Grimsey et al.   Cell Reports

Detection of dysregulated protein-association networks by high-throughput proteomics predicts cancer vulnerabilities

(2017) John D Lapek et al.   NATURE BIOTECHNOLOGY

Occupancy of human EPCR by protein C induces  -arrestin-2 biased PAR1 signaling by both APC and thrombin

(2016) R. V. Roy et al.   BLOOD

Activated protein C: biased for translation

(2015) J. H. Griffin et al.   BLOOD

Ubiquitin plays an atypical role in GPCR-induced p38 MAP kinase activation on endosomes

(2015) Neil J. Grimsey et al.   JOURNAL OF CELL BIOLOGY

Single-step Enrichment by Ti4+-IMAC and Label-free Quantitation Enables In-depth Monitoring of Phosphorylation Dynamics with High Reproducibility and Temporal Resolution

(2014) Erik L. de Graaf et al.   MOLECULAR & CELLULAR PROTEOMICS

VE-Cadherin and Endothelial Adherens Junctions: Active Guardians of Vascular Integrity

(2013) Monica Giannotta et al.   DEVELOPMENTAL CELL

Binding to F-actin guides cadherin cluster assembly, stability, and movement

(2013) Soonjin Hong et al.   JOURNAL OF CELL BIOLOGY

Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X

(2013) Po-Chao Chan et al.   JOURNAL OF CELL BIOLOGY

Cellular and molecular regulation of vascular permeability

(2013) Lauren Goddard et al.   THROMBOSIS AND HAEMOSTASIS

Role of G protein-coupled receptors in inflammation

(2012) Lei Sun et al.   ACTA PHARMACOLOGICA SINICA

A novel significance score for gene selection and ranking

(2012) Yufei Xiao et al.   BIOINFORMATICS

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Vinculin associates with endothelial VE-cadherin junctions to control force-dependent remodeling

(2012) Stephan Huveneers et al.   JOURNAL OF CELL BIOLOGY

Thrombin and vascular inflammation

(2011) Milan Popović et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broken Barriers: A New Take on Sepsis Pathogenesis

(2011) N. M. Goldenberg et al.   Science Translational Medicine

Regulation of Endothelial Permeability via Paracellular and Transcellular Transport Pathways

(2010) Yulia Komarova et al.   Annual Review of Physiology

Signal transduction by protease-activated receptors

(2010) Unice JK Soh et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications

(2009) Elisabetta Dejana et al.   DEVELOPMENTAL CELL

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity

(2009) Huang Guo et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vascular permeability in cardiovascular disease and cancer

(2008) Sara M Weis   CURRENT OPINION IN HEMATOLOGY