Activated protein C binds directly to Tie2: possible beneficial effects on endothelial barrier function

Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity

(2014) F. Stavenuiter et al.   BLOOD

Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A2

(2014) Meilang Xue et al.   ARTHRITIS RESEARCH & THERAPY

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

(2013) L. Burnier et al.   BLOOD

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

(2013) Tilman Ziegler et al.   JOURNAL OF CLINICAL INVESTIGATION

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

(2012) Sascha David et al.   CRITICAL CARE MEDICINE

sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove

(2011) J. Lopez-Sagaseta et al.   BLOOD

Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2

(2010) Meilang Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

(2010) Chunzhang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Thrombin up-regulates the Angiopoietin/Tie2 Axis: EPCR occupancy prevents the thrombin mobilization of angiopoietin2 and P-selectin from Weibel-Palade bodies

(2010) Jong-Sup Bae et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Angiopoietin-2, Marker and Mediator of Endothelial Activation With Prognostic Significance Early After Trauma?

(2009) Michael T. Ganter et al.   ANNALS OF SURGERY

Recombinant human activated protein C inhibits integrin-mediated neutrophil migration

(2009) G. F. Elphick et al.   BLOOD

Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction

(2009) Mark W. Gramling et al.   EXPERIMENTAL CELL RESEARCH

Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function

(2009) Nikita Minhas et al.   FASEB JOURNAL

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

(2009) H. T. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Caveolae are required for protease-selective signaling by protease-activated receptor-1

(2009) A. Russo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppressive effect of secretory phospholipase A2 inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice

(2009) Maung-Maung Thwin et al.   ARTHRITIS RESEARCH & THERAPY

The angiopoietin-Tie2 system as a therapeutic target in sepsis and acute lung injury

(2008) Melanie van der Heijden et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Divergent roles of endothelial NF-κB in multiple organ injury and bacterial clearance in mouse models of sepsis

(2008) Xiaobing Ye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult

(2008) Wendy L Thompson et al.   Journal of Neuroinflammation

Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells

(2008) X. V. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High throughput adjustable 96-well plate assay for androgen receptor binding: A practical approach for EDC screening using the chimpanzee AR☆

(2008) P HARTIG et al.   TOXICOLOGY LETTERS