Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

(2009) F. Niessen et al.   BLOOD

Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity

(2009) Huang Guo et al.   JOURNAL OF NEUROCHEMISTRY

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

The effect of mutant SOD1 dismutase activity on non-cell autonomous degeneration in familial amyotrophic lateral sclerosis

(2009) Lijun Wang et al.   NEUROBIOLOGY OF DISEASE

Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice

(2009) C. S. Lobsiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activated protein C via PAR1 receptor regulates survival of neurons under conditions of glutamate excitotoxicity

(2008) L. R. Gorbacheva et al.   BIOCHEMISTRY-MOSCOW

Endothelial Protein C Receptor-Assisted Transport of Activated Protein C across the Mouse Blood—Brain Barrier

(2008) Rashid Deane et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Activated Protein C Promotes Neovascularization and Neurogenesis in Postischemic Brain via Protease-Activated Receptor 1

(2008) M. Thiyagarajan et al.   JOURNAL OF NEUROSCIENCE

The curious ways of ALS

(2008) Magdalini Polymenidou et al.   NATURE

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE