Noncanonical PAR3 activation by factor Xa identifies a novel pathway for Tie2 activation and stabilization of vascular integrity

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3

(2013) L. Burnier et al.   BLOOD

An Activated Protein C Analog Stimulates Neuronal Production by Human Neural Progenitor Cells via a PAR1-PAR3-S1PR1-Akt Pathway

(2013) H. Guo et al.   JOURNAL OF NEUROSCIENCE

Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46

(2012) L. O. Mosnier et al.   BLOOD

Cytoprotective signaling by activated protein C requires protease-activated receptor-3 in podocytes

(2011) T. Madhusudhan et al.   BLOOD

Activated protein C promotes protease-activated receptor-1 cytoprotective signaling through  -arrestin and dishevelled-2 scaffolds

(2011) U. J. K. Soh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoprotective protein C pathways and implications for stroke and neurological disorders

(2011) Berislav V. Zlokovic et al.   TRENDS IN NEUROSCIENCES

Endogenous protein C is essential for the functional integrity of human endothelial cells

(2010) Meilang Xue et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Factor X/Xa Elicits Protective Signaling Responses in Endothelial Cells Directly via PAR-2 and Indirectly via Endothelial Protein C Receptor-dependent Recruitment of PAR-1

(2010) Jong-Sup Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated Protein C Enhances Human Keratinocyte Barrier Integrity via Sequential Activation of Epidermal Growth Factor Receptor and Tie2

(2010) Meilang Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of Rapid Myosin Regulatory Light Chain Phosphorylation Using High-Throughput In-Cell Western Assays: Comparison to Western Immunoblots

(2010) Hector N. Aguilar et al.   PLoS One

The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications

(2009) S. Danese et al.   BLOOD

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant

(2009) L. O. Mosnier et al.   BLOOD

Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function

(2009) Nikita Minhas et al.   FASEB JOURNAL

Coagulation factor Xa cleaves protease-activated receptor-1 and mediates signaling dependent on binding to the endothelial protein C receptor

(2009) R. A. SCHUEPBACH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY