Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity

Radiation-Induced Lipid Peroxidation Triggers Ferroptosis and Synergizes with Ferroptosis Inducers

(2020) Ling F. Ye et al.   ACS Chemical Biology

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

H2A monoubiquitination links glucose availability to epigenetic regulation of the endoplasmic reticulum stress response and cancer cell death

(2020) Yilei Zhang et al.   CANCER RESEARCH

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

(2020) Xiaoguang Liu et al.   NATURE CELL BIOLOGY

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy

(2020) Pranavi Koppula et al.   Protein & Cell

Organoids — Preclinical Models of Human Disease

(2019) Mo Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

The deubiquitylase OTUB1 mediates ferroptosis via stabilization of SLC7A11

(2019) Tong Liu et al.   CANCER RESEARCH

DUBbing Ferroptosis in Cancer Cells

(2019) Boyi Gan   CANCER RESEARCH

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

(2019) Oded Kopper et al.   NATURE MEDICINE

Mechanistic basis for impaired ferroptosis in cells expressing the African-centric S47 variant of p53

(2019) Julia I-Ju Leu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–

(2019) Liyuan Wang et al.   CELL DEATH AND DIFFERENTIATION

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

BAP1 links metabolic regulation of ferroptosis to tumour suppression

(2018) Yilei Zhang et al.   NATURE CELL BIOLOGY

Role of Mitochondria in Ferroptosis

(2018) Minghui Gao et al.   MOLECULAR CELL

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

An African-specific polymorphism in theTP53gene impairs p53 tumor suppressor function in a mouse model

(2016) Matthew Jennis et al.   GENES & DEVELOPMENT

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

(2014) Aifu Lin et al.   CANCER RESEARCH

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

p53 promotes repair of heterochromatin DNA by regulating JMJD2b and SUV39H1 expression

(2013) H Zheng et al.   ONCOGENE

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Molecular Pathways: Targeted  -Particle Radiation Therapy

(2012) K. E. Baidoo et al.   CLINICAL CANCER RESEARCH

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

Image-guided radiotherapy: from current concept to future perspectives

(2012) David A. Jaffray   Nature Reviews Clinical Oncology

The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond

(2011) Marcus Conrad et al.   AMINO ACIDS

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury

(2011) Edouard I. Azzam et al.   CANCER LETTERS

Solute carrier protein family may involve in radiation-induced radioresistance of non-small cell lung cancer

(2011) Li Xie et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL